Advances in Clinical Chemistry
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Advances in Clinical Chemistry, Volume 106, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release focusing on Advances in ADAMTS biomarkers, Advances in fibrosis biomarkers in nonalcoholic fatty liver disease, Metabolomics of Peripheral Artery Disease, Molecular and cellular functions of long non-coding RNAS in prostate and breast cancer, Myostatin: Basic Biology to Clinical Application, and Metadherin (AEG-1/MTDH/LYRIC) expression: Significance in malignancy and crucial role in colorectal cancer.
Key Features
- Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science
- Authored by world renowned clinical laboratory scientists, physicians and research scientists
- Presents the international benchmark for novel analytical approaches in the clinical laboratory
Readership
Clinical Laboratory Professionals, Physicians and Research Scientists
Table of Contents
- Cover
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: Advances in ADAMTS biomarkers
- Abstract
- 1: Introduction
- 2: Structure and proteolytic mechanism
- 3: ADAMTS13 an important regulator of thrombotic thrombocytopenic purpura (TTP)
- 4: ADAMTS4 and 5 are major players in osteoarthritis
- 5: ADAMTSs in connective tissue diseases
- 6: ADAMTSs in cancer
- 7: Novel approaches in ADAMTS substrate identification to promote ADAMTS biomarker identification
- 8: Outlook and future perspective
- References
- Chapter Two: Advances in fibrosis biomarkers in nonalcoholic fatty liver disease
- Abstract
- 1: Introduction
- 2: Epidemiology and the importance of liver fibrosis
- 3: The need for reliable non-invasive biomarkers of fibrosis
- 4: Non-invasive diagnostic modalities of liver fibrosis
- 5: Emerging technologies
- 6: Conclusions
- References
- Chapter Three: Metabolomics of peripheral artery disease
- Abstract
- Graphical abstract
- 1: Introduction
- 2: Methodology
- 3: Metabolomics of peripheral artery disease
- 4: Concluding remarks
- References
- Chapter Four: Molecular and cellular functions of long non-coding RNAs in prostate and breast cancer
- Abstract
- 1: Introduction
- 2: Long noncoding RNAs (LncRNAs)
- 3: Cellular functions of LncRNAs in prostate cancer
- 4: Cellular functions of LncRNAs in breast cancer
- 5: Conclusion and perspectives
- References
- Chapter Five: Myostatin: Basic biology to clinical application
- Abstract
- 1: Introduction
- 2: Myostatin biology
- 3: Myostatin and skeletal muscle
- 4: Myostatin in experimental and human diseases
- 5: Myostatin as a therapeutic target: Data from human studies
- 6: Limitations and future developments
- References
- Chapter Six: Metadherin (AEG-1/MTDH/LYRIC) expression: Significance in malignancy and crucial role in colorectal cancer
- Abstract
- 1: Introduction
- 2: Metadherin (AEG-1/MTDH/LYRIC)
- 3: Metadherin and colorectal cancer (CRC)
- 4: Conclusion and future perspectives
- References
- Index
Product details
- No. of pages: 298
- Language: English
- Copyright: © Academic Press 2022
- Published: January 14, 2022
- Imprint: Academic Press
- Hardcover ISBN: 9780323988377
- eBook ISBN: 9780323988384
About the Editor
Gregory Makowski
Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.
Affiliations and Expertise
Vice President and Chief Scientific Officer, Clinical Laboratory Partners, Newington, CT, USA
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