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Advances in Clinical Chemistry - 1st Edition - ISBN: 9780128120767, 9780128121795

Advances in Clinical Chemistry, Volume 79

1st Edition

Serial Editor: Gregory Makowski
Hardcover ISBN: 9780128120767
eBook ISBN: 9780128121795
Imprint: Academic Press
Published Date: 14th February 2017
Page Count: 264
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Table of Contents

Chapter One: CTRP1 in Liver Disease

  • Abstract
  • 1 Introduction
  • 2 Adiponectin and the C1q Family
  • 3 CTRP1 Characteristics
  • 4 Regulation of CTRP1
  • 5 CTRP1 and NAFLD
  • 6 Critical Evaluation of CTRP1
  • 7 Conclusion

Chapter Two: Rationally Designed Peptide Probes for Extracellular Vesicles

  • Abstract
  • 1 Introduction
  • 2 Biological Importance of EVs
  • 3 Isolation and Quantification
  • 4 Probes for EVs
  • 5 Applications
  • 6 Conclusions and Future Perspectives
  • Acknowledgments

Chapter Three: Droplet-Based Digital PCR: Application in Cancer Research

  • Abstract
  • 1 Introduction
  • 2 Digital Procedures for Biomarker Testing: A Historical Overview
  • 3 Droplet-Based Digital PCR Procedures: Applications to the Detection of Known Targets
  • 4 Conclusions and Future Perspectives
  • Acknowledgments

Chapter Four: Novel Biomarkers of Heart Failure

  • Abstract
  • 1 Introduction
  • 2 Biomarkers of Myocardial Stretch
  • 3 Biomarkers of Myocyte Injury
  • 4 Biomarkers of Matrix Remodeling
  • 5 Biomarkers of Inflammation
  • 6 Biomarkers of Renal Dysfunction
  • 7 Biomarkers Neurohumoral Activation
  • 8 Biomarkers of Oxidative Stress
  • 9 Future Aspects
  • 10 Conclusion
  • Acknowledgments

Chapter Five: Advances in Clinical Mass Spectrometry

  • Abstract
  • 1 Introduction
  • 2 Gas Chromatography-Mass Spectrometry
  • 3 Liquid Chromatography-Tandem Mass Spectrometry
  • 4 Sample Preparation
  • 5 Clinical Applications of Mass Spectrometry
  • 6 Recent Advances in Clinical Mass Spectrometry
  • 7 Conclusions

Chapter Six: Testing for Chronic Diarrhea

  • Abstract
  • 1 Definition of Chronic Diarrhea
  • 2 Classification of Chronic Diarrhea
  • 3 Diagnosis of Chronic Diarrhea
  • 4 Testing for Chronic Diarrhea
  • 5 Testing for Steatorrhea
  • 6 Secretory Diarrhea
  • 7 Inflammatory Diarrhea
  • 8 Osmotic Diarrhea
  • 9 Hypermotility-Related Diarrhea
  • 10 Integrated Approach to Investigating Chronic Diarrhea


Advances in Clinical Chemistry, Volume 79 is the latest installment in this internationally acclaimed series and contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Key Features

  • Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science
  • Authored by world renowned clinical laboratory scientists, physicians, and research scientists
  • Presents the international benchmark for novel analytical approaches in the clinical laboratory


Clinical Laboratory Professionals, Physicians and Research Scientists


No. of pages:
© Academic Press 2017
14th February 2017
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Serial Editor

Gregory Makowski

Gregory Makowski

Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.

Affiliations and Expertise

Clinical Laboratory Partners, Newington; Hartford Hospital, Hartford; Department of Laboratory Medicine, University of Connecticut Health Center, Farmington, CT, USA