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Advances in Clinical Chemistry - 1st Edition - ISBN: 9780128046906, 9780128048412

Advances in Clinical Chemistry, Volume 73

1st Edition

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Serial Editor: Gregory Makowski
Hardcover ISBN: 9780128046906
eBook ISBN: 9780128048412
Imprint: Academic Press
Published Date: 3rd March 2016
Page Count: 268
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Table of Contents

Chapter One: Antibodies to Phosphatidylserine/Prothrombin Complex in Antiphospholipid Syndrome: Analytical and Clinical Perspectives

  • Abstract
  • 1 Introduction
  • 2 Historic Background to aPL
  • 3 “Criteria” Antiphospholipid Antibody Tests
  • 4 aPL and Pathogenesis of APS
  • 5 Antibodies to Phosphatidylserine/Prothrombin Complex
  • 6 Clinical and Laboratory Significance of aPS/PT Antibodies
  • 7 Analytic and Diagnostic Challenges Associated with aPS/PT Antibodies
  • 8 Perspectives and Opportunities for the Future
  • 9 Conclusion

Chapter Two: Copeptin in Heart Failure

  • Abstract
  • 1 Introduction
  • 2 Neurohormonal Activation in HF
  • 3 The Vasopressin System in HF
  • 4 Limitations of Vasopressin Measurements in Clinical Settings
  • 5 Structure and Function of Copeptin
  • 6 Copeptin in Healthy Populations
  • 7 Copeptin in Other Heart Diseases than HF
  • 8 Copeptin in HF
  • 9 Association of Copeptin and Hyponatremia in HF
  • 10 Copeptin and Comorbidity in HF
  • 11 Copeptin and Medical Therapy in HF
  • 12 Conclusion and Future Perspectives on Copeptin in HF
  • Acknowledgments

Chapter Three: Immunosensors in Clinical Laboratory Diagnostics

  • Abstract
  • 1 Introduction
  • 2 Classification of Immunosensors
  • 3 Applications of Immunosensors for Clinical Diagnostics
  • 4 Final Remarks and Perspectives
  • Acknowledgments

Chapter Four: Cancer Stem Cell Biomarker Discovery Using Antibody Array Technology

  • Abstract
  • 1 Introduction
  • 2 Evidence of Cancer Stem Cell Populations in Circulating Tumors: Biomarker-Based CSC Discovery
  • 3 Antibody Array-Based Discovery of Local Cancer Stem Cell Signaling Mechanisms
  • 4 Conclusions
  • Acknowledgments

Chapter Five: Biochemistry of Statins

  • Abstract
  • 1 Introduction
  • 2 Structure
  • 3 Pharmacokinetics
  • 4 Mechanism of Action
  • 5 Administration
  • 6 Efficacy
  • 7 Side Effects
  • 8 Statin Intolerance
  • 9 Conclusion

Chapter Six: The Importance of Magnesium in the Human Body: A Systematic Literature Review

  • Abstract
  • 1 Introduction
  • 2 Method
  • 3 Results
  • 4 Discussion
  • 5 Conclusion

Chapter Seven: Inborn Errors of Metabolism

  • Abstract
  • 1 Inborn Errors of Metabolism


Advances in Clinical Chemistry, Volume 73, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Key Features

  • Contains the expertise of international contributors
  • Provides the latest cutting-edge technologies in the field
  • Authored by world-renowned clinical laboratory scientists, physicians, and research scientists


Clinical Laboratory Professionals, Physicians and Research Scientists


No. of pages:
© Academic Press 2016
3rd March 2016
Academic Press
Hardcover ISBN:
eBook ISBN:

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About the Serial Editor

Gregory Makowski

Gregory Makowski

Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.

Affiliations and Expertise

Clinical Laboratory Partners, Newington; Hartford Hospital, Hartford; Department of Laboratory Medicine, University of Connecticut Health Center, Farmington, CT, USA