Advances in Clinical Chemistry - 1st Edition - ISBN: 9780128022658, 9780128024645

Advances in Clinical Chemistry, Volume 69

1st Edition

Serial Editors: Gregory Makowski
eBook ISBN: 9780128024645
Hardcover ISBN: 9780128022658
Imprint: Academic Press
Published Date: 24th April 2015
Page Count: 346
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Table of Contents

  • Preface
  • Chapter One: D-dimer: An Overview of Hemostasis and Fibrinolysis, Assays, and Clinical Applications
    • Abstract
    • 1 Introduction
    • 2 Overview of Hemostasis
    • 3 Mechanisms of Fibrinolysis
    • 4 Clinical Detection of the Products of Fibrinolysis
    • 5 Clinical Applications of D-dimer
    • 6 Conclusions
  • Chapter Two: Circulating Biomarkers in Malignant Melanoma
    • Abstract
    • 1 Some Clinical and Epidemiological Aspects of Melanoma
    • 2 Tumor Biology
    • 3 Circulating Tumor Cells as Biomarkers
    • 4 Circulating Nucleic Acids as Biomarkers
    • 5 Proteins as Tumor Markers
    • 6 Tumor Markers in Guidelines
    • 7 Concluding Remarks
    • Acknowledgments
  • Chapter Three: Cancer Therapy and Replication Stress: Forks on the Road to Perdition
    • Abstract
    • 1 Introduction
    • 2 Eukaryotic DNA Replication
    • 3 DNA-Damaging Agents and Replication Fork Progression
    • 4 The Fates of the Perturbed Forks
    • 5 How Does Replication Inhibition Cause Cell Death?
    • 6 How Is the Replication Stress Response Altered in Cancer?
    • 7 Conclusions
    • Acknowledgments
  • Chapter Four: Soluble ST2 in Ventricular Dysfunction
    • Abstract
    • 1 Introduction
    • 2 Biological Background and Function of ST2
    • 3 sST2 in Experimental Observations
    • 4 ST2 in Clinical Studies
    • 5 Future Perspectives
    • 6 Conclusion
  • Chapter Five: Biofluid Proteases Profiling in Diabetes Mellitus
    • Abstract
    • 1 Introduction
    • 2 Proteases in the Pathogenesis of DM and its Related Complications
    • 3 Biofluid Proteases as Biomarkers in Diabetes Mellitus
    • 4 Methods for Screening Proteases and Their Inhibitors in Biofluids
    • 5 Therapeutic Targeting of Proteases in DM
    • 6 Future Directions
    • Acknowledgments
  • Chapter Six: Biomarker Characterization by MALDI–TOF/MS
    • Abstract
    • 1 Introduction
    • 2 Mass Spectrometry for Clinical Diagnosis
    • 3 Applications of MALDI–TOF/MS in Clinical Diagnosis
    • 4 Methods for Improving Detection Efficiency of Disease Biomarkers by MALDI–TOF/MS
    • 5 Conclusions
    • Acknowledgments
  • Chapter Seven: Antibody Arrays in Biomarker Discovery
    • Abstract
    • 1 The Origin of Biomarkers
    • 2 Antibody Array Platforms and Utility
    • 3 Antibody Arrays in Drug Target Discovery
    • 4 Antibody Arrays in Therapeutic Biomarker Discovery
    • 5 Cytokine Antibody Arrays in Asthma Biomarker Discovery
    • 6 Cytokine Antibody Arrays in Neurological & Neurodegenerative Disease Biomarker Discovery
    • 7 Antibody Arrays in Immune-Mediated Diseases
    • 8 Antibody Array in Cancer Discovery
    • 9 Kidney Diseases
    • 10 Other Diseases Where Antibody Arrays Have Contributed to Biomarker Identification
    • 11 Other Array Technologies
    • 12 Summary
    • Acknowledgments
  • Index


Volume 69 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Key Features

  • Expertise of international contributors
  • Latest cutting-edge technologies
  • Comprehensive in scope


Clinical Laboratory Professionals, Physicians and Research Scientists


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© Academic Press 2015
Academic Press
eBook ISBN:
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Ratings and Reviews

About the Serial Editors

Gregory  Makowski

Gregory Makowski Serial Editor

Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.

Affiliations and Expertise

Clinical Laboratory Partners, Newington; Hartford Hospital, Hartford; Department of Laboratory Medicine, University of Connecticut Health Center, Farmington, CT, USA