Advances in Clinical Chemistry - 1st Edition - ISBN: 9780128022566, 9780128025222

Advances in Clinical Chemistry, Volume 71

1st Edition

Serial Editors: Gregory Makowski
eBook ISBN: 9780128025222
Hardcover ISBN: 9780128022566
Imprint: Academic Press
Published Date: 24th September 2015
Page Count: 220
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Table of Contents

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  • Preface
  • Chapter One: Biomarkers in Breast Cancer: Where Are We and Where Are We Going?

    • Abstract
    • 1 Use of Biomarkers in the Identification of Women at Increased Risk of Developing Breast Cancer (Risk Assessment)
    • 2 Use of Biomarkers in Determining Prognosis
    • 3 Use of Biomarkers in Guiding Treatment
    • 4 Use of Biomarkers in the Postoperative Follow-Up of Asymptomatic Patients Following Curative Surgery
    • 5 Use of Biomarkers in Monitoring Therapy in Patients with Metastasis
    • 6 Emerging Biomarkers for Breast Cancer
    • 7 Conclusion
    • Acknowledgments
  • Chapter Two: Polycystic Ovary Syndrome-Epigenetic Mechanisms and Aberrant MicroRNA

    • Abstract
    • 1 Introduction
    • 2 The Epigenetic Landscape
    • 3 miRNA
    • 4 Conclusions
    • Acknowledgments
  • Chapter Three: EN2 in Prostate Cancer

    • Abstract
    • 1 Introduction
    • 2 Risk Factors and Conventional Biomarkers of Prostate Cancer
    • 3 Biomarkers with Clinical Application in Urine
    • 4 Antitumor Antibodies as Biomarkers
    • 5 The Homeobox Gene Superfamily
    • 6 The Biology of En
    • 7 En in Cancer
    • 8 En as a Potential Biomarker in Cancer
    • 9 EN2 in Prostate Cancer
    • 10 EN2 as a Diagnostic Marker and Marker of Significant Disease
    • 11 EN2 in Men at High Risk of Prostate Cancer
    • 12 Future Perspectives
    • 13 Conclusion
  • Chapter Four: Cytochrome P450 in Cancer Susceptibility and Treatment

    • Abstract
    • 1 Introduction
    • 2 Classification, Nomenclature, and Structure of Cytochromes P450
    • 3 Drug Metabolism
    • 4 Genetic Variations in CYP450 Isoforms
    • 5 CYP450 in Cancer Susceptibility
    • 6 CYP450 in Anticancer Therapy
    • 7 Conclusion
    • Acknowledgments
  • Chap


Advances in Clinical Chemistry, Volume 71, is the latest installment in this internationally acclaimed series. This latest volume contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Key Features

  • Expertise of international contributors
  • Latest cutting-edge technologies


Clinical Laboratory Professionals, Physicians and Research Scientists


No. of pages:
© Academic Press 2015
Academic Press
eBook ISBN:
Hardcover ISBN:

Ratings and Reviews

About the Serial Editors

Gregory Makowski Serial Editor

Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.

Affiliations and Expertise

Clinical Laboratory Partners, Newington; Hartford Hospital, Hartford; Department of Laboratory Medicine, University of Connecticut Health Center, Farmington, CT, USA