Advances in Clinical Chemistry - 1st Edition - ISBN: 9780128000946, 9780128003565

Advances in Clinical Chemistry, Volume 63

1st Edition

Serial Editors: Gregory Makowski
eBook ISBN: 9780128003565
Hardcover ISBN: 9780128000946
Imprint: Academic Press
Published Date: 13th January 2014
Page Count: 332
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Table of Contents

  • Contributors
  • Preface
  • Chapter One. Vitamin D Binding Protein: A Multifunctional Protein of Clinical Importance
    • Abstract
    • 1 Introduction
    • 2 Identification of DBP Polymorphisms and Its Geographical Distribution
    • 3 Analytical Issues
    • 4 The Multifunctional Character of DBP (Fig. 1.3)
    • 5 Clinical Importance of DBP in Cancer (Table 1.1A)
    • 6 Clinical Importance of DBP in Noncancer-Related Diseases (Table 1.1B)
    • 7 DBP as a Therapeutic Agent
    • References
  • Chapter Two. Free Testosterone: Clinical Utility and Important Analytical Aspects of Measurement
    • Abstract
    • Abbreviations
    • 1 Androgen Physiology
    • 2 Clinical Utility of Measuring Testosterone
    • 3 Laboratory Methods for Measuring Free and BAT
    • 4 Conclusions
    • References
  • Chapter Three. Urine Retinol-Binding Protein 4: A Functional Biomarker of the Proximal Renal Tubule
    • Abstract
    • 1 Introduction
    • 2 Nomenclature
    • 3 History
    • 4 Molecular Structure, Interactions, and Transport of Plasma RBP4
    • 5 Renal Handling of RBP4 and Other Plasma Proteins
    • 6 RBP4 in Plasma and Urine Excretion
    • 7 uRBP4 Assay
    • 8 Stability of uRBP4
    • 9 Clinical Application of uRBP4 Measurement
    • 10 Toxicology and Drug Effects
    • 11 HIV Disease
    • 12 Summary
    • 13 Executive Summary
    • References
  • Chapter Four. Proteomics for Breast Cancer Urine Biomarkers
    • Abstract
    • Abbreviations
    • 1 Introduction
    • 2 Current BC Biomarker Studies Using Proteomics
    • 3 Urine as a Potential Source for Biomarkers
    • 4 Potential Urine Biomarkers Identified Using Proteomic Techniques in BC
    • 5 Key Proteomic Techniques in Urine Biomarker Research
    • 6 Conclusions and Future Directions
    • Acknowledgments
    • References
  • Chapter Five. Pregnancy-Associated Plasma Protein A (PAPP-A) and Preeclampsia
    • Abstract
    • Abbreviations
    • 1 Preeclampsia—Basic Information and Markers
    • 2 PAPP-A and the Current State of the Art
    • 3 Measuring the Concentration of PAPP-A
    • 4 PAPP-A in Pregnancy
    • 5 PAPP-A as a Marker of Other Diseases
    • 6 Conclusion
    • Acknowledgments
    • References
  • Chapter Six. Pediatric Hypoglycemia
    • Abstract
    • 1 Definition of Hypoglycemia
    • 2 Short- and Long-Term Consequences
    • 3 Transition from Fetal to Neonatal Glucose Homeostasis
    • 4 Monitoring of Neonatal Hypoglycemia and At-Risk Groups
    • 5 Biochemistry of Hypoglycemia
    • 6 Idiopathic Ketotic Hypoglycemia
    • 7 Drug-Related Hypoglycemia
    • 8 Point-of-Care Testing for Hypoglycemia
    • 9 Laboratory Investigation of Hypoglycemia
    • 10 Conclusion
    • References
  • Chapter Seven. Paraoxonases and Chemokine (C–C Motif) Ligand-2 in Noncommunicable Diseases
    • Abstract
    • 1 Obesity in Noncommunicable Diseases
    • 2 Paraoxonases and Regulation of Oxidative Stress
    • 3 Chemokine Superfamily: Migration of Immune Cells In Vivo
    • 4 Chronic Liver Diseases: Oxidative Stress and Inflammation
    • 5 Measurement of PON Enzymes and CCL2
    • 6 Conclusion
    • Acknowledgments
    • References
  • Index


Volume 63 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Key Features

  • Expertise of international contributors
  • Latest cutting-edge technologies
  • Comprehensive in scope


Clinical Laboratory Professionals, Physicians and Research Scientists


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© Academic Press 2014
Academic Press
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Ratings and Reviews

About the Serial Editors

Gregory  Makowski

Gregory Makowski Serial Editor

Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.

Affiliations and Expertise

Clinical Laboratory Partners, Newington; Hartford Hospital, Hartford; Department of Laboratory Medicine, University of Connecticut Health Center, Farmington, CT, USA