Advances in Clinical Chemistry, Volume 59

Contributors

Preface

Chapter One. Human Epididymis Protein 4 in Cancer Diagnostics

1 Introduction

2 General Characteristics (Fig. 1.1)

3 Analytical Methods

4 Cancer Diagnostics (Table 1.1)

5 Discussion

References

Chapter Two. Pathophysiological Roles and Clinical Importance of Biomarkers in Acute Coronary Syndrome

1 Introduction

2 Pathogenesis Underlying Myocardial Ischemia/Infarction

3 Ideal Cardiac Biomarkers

4 History of Cardiac Biomarkers

5 Myocardial Dysfunction

6 Myocardial Necrosis

7 Myocardial Ischemia

8 Biomarkers of Inflammation

9 Perspectives and Future Strategies

10 Conclusion

References

Chapter Three. Paraoxonases

1 Historical Overview: From Toxicology to Cardiovascular Disease

2 The PON Enzyme Family

3 PON as Multitasking Enzymes: Pathways Related to Atherosclerosis

4 PON and Ischemic Heart Disease: Animal Studies

5 PON and Ischemic Heart Disease: Epidemiologic and Clinical Studies

6 PON1 as a Potential Therapeutic Tool

7 Concluding Remarks

References

Chapter Four. Mucosal Healing in Ulcerative Colitis

1 Introduction

2 Molecular Pathways of Intestinal Mucosal Wounding in Ulcerative Colitis

3 Epithelial Healing in Ulcerative Colitis Has an Impact on Disease Course

4 The Pharmacodynamics of Wound Healing

5 Conclusions

References

Chapter Five. Reticulocytes in Sports Medicine

1 Introduction

2 Preanalytical Phase

3 Kinetics of Ret Production in Humans

4 Reported Ret Values in Athletes

5 Stability

6 Comparison of Ret Values Between Athletes and Sedentary People

7 Effects of Exercise on Ret

8 Doping

9 Conclusions

References

Chapter Six. Toll-Like Receptors in Liver Disease

1 Introduction

2 The Role of Toll-Like Receptors in Innate Immunity

3 Expression of Toll-Like Receptors in the Liver

4 Toll-Like Receptors in the Pathogenesis of Liver Diseases

5 The Role of TLR in the Pathogenesis of Long-Term Consequences of ALD and NASH

6 TLR Signaling as Target for Therapy of ALD and NASH

7 Synergy Between Alcohol Consumption and NAFLD

8 Conclusions

References

Chapter Seven. Procalcitonin in Pediatrics

Abbreviations

1 Introduction

2 PCT and the Newborn

3 PCT and the Ill Infant and Child

4 Conclusions

References

Index

Volume 59 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology.

• Written by authors representing the diverse field of clinical chemistry and diagnostics, reviews in Advances in Clinical Chemistry cover a range of cutting-eduge research ranging from basic biochemical exploration to microarray technology

Biochemists and clinical biochemists