Advances in Clinical Chemistry - 1st Edition - ISBN: 9780123737038, 9780080469201

Advances in Clinical Chemistry, Volume 43

1st Edition

Serial Editors: Gregory Makowski
eBook ISBN: 9780080469201
Hardcover ISBN: 9780123737038
Imprint: Academic Press
Published Date: 27th December 2006
Page Count: 304
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Table of Contents

  • Contributors to Volume 43

    • Publisher Summary
  • Preface

    • Publisher Summary
  • The Heme Catabolic Pathway and its Protective Effects on Oxidative Stress-Mediated Diseases

    • 1. Abstract
    • 2 Introduction
    • 3 Heme Catabolism
    • 4 Heme Oxygenase
    • 5 Hemodynamic and Cytoprotective Effects of Carbon Monoxide
    • 6 Cytoprotective Effects of Biliverdin Reductase
    • 7 Biological Effects of Bilirubin
    • 8 Factors Affecting Serum Bilirubin Concentrations
    • 9 Therapeutic Agents Affecting HO-1 Activity, CO, and Bilirubin Production
    • 10 Conclusions
    • Acknowledgment
  • Cyclooxygenase-2 and Tumor Biology

    • 1. Abstract
    • 2 Introduction
    • 3 Proposed Roles for COX-2 in Carcinogenesis
    • 4 COX-2 Expression and Clinicopathological Factors
    • 5 Fecal COX-2 Assay
    • 6 Conclusions
    • Acknowledgments
  • Oligonucleotide Probes for RNA-Targeted Fluorescence In Situ Hybridization

    • 1. Abstract
    • 2 Introduction
    • 3 Principles of Fluorescence In Situ Hybridization
    • 4 Types of Probes
    • 5 Applications
    • 6 Conclusions
    • Acknowledgments
  • Activin A In Brain Injury

    • 1. Abstract
    • 2 Introduction
    • 3 Biochemistry
    • 4 Activin A After Brain Injury in Animals
    • 5 Activin A and Neuroprotection: Findings from Animal Studies
    • 6 Human Studies
    • 7 Conclusions
  • Methods for Predicting Human Drug Metabolism

    • 1. Abstract
    • 2 Introduction
    • 3 In Vitro Techniques
    • 4 High-Throughput Assays
    • 5 In Vivo Predictions from In Vitro
    • 6 Computational Metabolism Methods
    • 7 Integration of Drug Metabolism Data and Interpretation
    • 8 Newer Technologies
    • 9 Conclusions
    • Acknowledgments
  • A Summary Analysis


Volume 43 of the Advances in Clinical Chemistry series contains review articles of wide interest to clinical laboratory scientists and diagnostic adventurers. In this volume, the biochemistry of bilirubin, the end-product of heme metabolism, is explored with respect to its potential beneficial role in preventing oxidative changes associated with a variety of pathological conditions, including atherosclerosis, cancer, and inflammatory, autoimmune and other degenerative diseases.


Biochemists and clinical biochemists.


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© Academic Press 2007
Academic Press
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About the Serial Editors

Gregory Makowski Serial Editor

Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.

Affiliations and Expertise

Clinical Laboratory Partners, Newington; Hartford Hospital, Hartford; Department of Laboratory Medicine, University of Connecticut Health Center, Farmington, CT, USA