Advances in Cellular Neurobiology

Advances in Cellular Neurobiology

Volume 5

1st Edition - January 28, 1984

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  • Editor: Sergey Fedoroff
  • eBook ISBN: 9781483266879

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Advances in Cellular Neurobiology, Volume 5 focuses on cellular neurobiology, drawing on some aspects of biochemistry, endocrinology, embryology, morphology, genetics, pharmacology, pathology, and physiology. This book deals with humoral influences on brain development. Organized into three sections encompassing 10 chapters, this volume begins with an overview of the proposed functions for neurohumoral agents, including cell division, neural tube closure, palate formation, myoblast differentiation, and regulation of cell movements. This text then examines how growth factors regulate autonomic nerve development. Other chapters consider the morphology, physiology, and biochemistry of the neuronal cytoskeleton. This book discusses as well the connective tissue components in the normal peripheral nervous system and in two pathological conditions. The final chapter deals with the advantages and preparation of monoclonal antibodies in the identification of neurons. This book is a valuable resource for neurobiologists and researchers. Scientists in all fields of life sciences will also find this book useful.

Table of Contents

  • Contributors


    Contents of Previous Volumes

    Section 1. Cell Differentiation and Interaction

    Humoral Influences on Brain Development

    I. Neurotransmitters as Developmental Signals

    II. Thyroid Hormones and Corticosteroids as Temporal Regulators of Postnatal Neurogenesis

    III. Hormonal-Humoral Interactions

    IV. Summary and Conclusions


    Growth Factors Regulating Autonomic Nerve Development

    I. Introduction

    II. Regulation of Neuronal Growth: NGF as a Model Factor

    III. Autonomie Development in Vivo

    IV. Nerve-Target Interactions

    V. Characterized Growth Factors

    VI. Summary and Conclusions


    The Neuronal Cytoskeleton

    I. Introduction

    II. Morphology and Cellular Distribution

    III. Biochemistry

    IV. Physiology and Function

    V. Pathology


    Electrophysiology of Neuropil Glial Cells in the Central Nervous System of the Leech: A Model System for Potassium Homeostatis in the Brain

    I. Introduction

    II. Morphology and Identification of Glial Cells in the Leech CNS

    III. Passive Electrical Properties of the Neuropil Glial Cell Membrane

    IV. Leech Neuropil Glial Cell Membrane Potential and Its Dependence on the External Potassium and Chloride Concentration

    V. Ionic Mechanism and Effect of 5-Hydroxytryptamine on Leech NG Cell Membranes

    VI. Conclusions


    The Connective Tissue Matrix of the Vertebrate PeripheralL Nervous System

    I. Introduction

    II. Methods of Study

    III. Proteoglycans of Nerves

    IV. Distribution of Elastic System Fibers in Nerves

    V. Identification and Differential Distribution of Collagen in Nerves

    VI. Collagen of Human Nerves in Two Pathological Models

    VII. Do Schwann Cells Produce Collagen Type III?

    VIII. Conclusions


    Section 2. Pathology

    Glial Cells in Huntington's Chorea

    I. Introduction

    II. Huntington's Chorea: A Case of Neuronal Death

    III. Astrogliosis in Huntington's Chorea

    IV. Oligodendrocytes and Myelin

    V. Glial-Glial and Glial-Neuronal Relationships

    VI. Trophic Interactions between Glial Cells and Neurons

    VII. Reactive Astrocytosis: Pathological Glial-Neuronal and Glial-Glial Interactions

    VIII. Reactive versus Normal Astrocytes

    IX. Glial Cell Markers

    X. Glutamate and Glial Cells

    XI. Membrane Changes in HC

    XII. GABA, Glial Cells, and Neurotransmission

    XIII. Conclusions


    Central Neurons in Culture in the Study of Spongiform Encephalopathies

    I. Introduction

    II. Culture of CNS Cells

    III. Identification of Cell Subpopulations 255

    IV. Autoantibodies Against Neurofilaments of Cultured Neurons in Subacute Spongiform Encephalopathies

    V. Conclusions


    Section 3. Methodologies

    Preparation of Monoclonal Antibodies and their Advantages in Identifying Specific Neurons

    I. Introduction

    II. The Leech Nervous System

    III. Methods

    IV. Monoclonal Antibodies that Give Rise to Restrictive Neuronal Labeling

    V. Mapping Antigenically Homologous Neurons Across the Entire CNS

    VI. Fixation Methods Can Differentiate between Monoclonal Antibody Cross-Reactivities

    VII. Monoclonal Antibodies Cross-React with Select Neuronal and Epithelial Tissue: Biochemical Characterization of Central and Peripheral Antigens

    VIII. The Expression of Antigens by Embryonic Neurons and Glial Cells

    IX. Conclusion


    Flourescent Neuronal Tracers

    I. Introduction

    II. Development of the Multiple Retrograde Fluorescent Tracer Technique for Demonstrating Axon Collaterals

    III. Differential Retrograde Labeling of Different Members of a Neuronal Population by Means of Fluorescent Tracers

    IV. The Use of Retrograde Fluorescent Tracers in Studying Developmental Changes in Fiber Connections in the Brain

    V. Anterograde Axonal Transport of Fluorescent Tracers

    VI. Combination of the Retrograde Tracers with Other Techniques

    VII. Methods for Using the Fluorescent Tracers Evans Blue (EB), DAPI, Primulin (Pr), DAPI/Primulin Mixture, Propidium Iodide (PI), Granular Blue (GB), True Blue (TB), Fast Blue (FB), Nuclear Yellow (NY), and Diamidino Yellow (DY)


    Computer-Assisted Reconstruction from Serial Electron Micographs: A Tool for the Systematic Study of Neuronal Form and Function

    I. Introduction

    II. When Is Serial Electron Microscopy Appropriate?

    III. General Problems Associated with Large-Scale Serial EM Reconstruction 347

    IV. Systematic Collection and Staining

    V. Systematic EM Photography

    VI. Systematic Computer Reconstruction

    VII. Analytical and Display Software

    VIII. Future Technical Improvements and Future Applications



Product details

  • No. of pages: 394
  • Language: English
  • Copyright: © Academic Press 1984
  • Published: January 28, 1984
  • Imprint: Academic Press
  • eBook ISBN: 9781483266879

About the Editor

Sergey Fedoroff

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