Advances in Cellular Neurobiology

Advances in Cellular Neurobiology

Volume 4

1st Edition - January 28, 1983

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  • Editors: Sergey Fedoroff, Leif Hertz
  • eBook ISBN: 9781483268156

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Advances in Cellular Neurobiology, Volume 4 focuses on the central nervous system. This book is divided into three main sections—cell differentiation and interaction, aging and pathology, and methodologies. The topics discussed include advances in the neurobiology of oligodendroglia; neuronal differentiation in reaggregate cell cultures; and morphological aspects of brain edema. The cell biological aspects of Down's syndrome; isolation and culture of cells of the dorsal root ganglia; and growth requirements of neural cells in vitro are also deliberated in this text. This publication is intended for neurologists, but is also beneficial to students researching on the anatomy and functional relation of the brain and spinal cord.

Table of Contents

  • Contributors


    Contents of Previous Volumes

    Section 1. Cell Differentiation and Interaction

    Recent Advances in the Neurobiology of Oligodendroglia

    I. Introduction

    II. Gliogenesis and Differentiation

    III. Gene Expression In Vitro

    IV. Bulk-Isolated Cells

    V. The Status of Cell-Specific Markers and Immunohistochemical Results

    VI. Neuronal-Glial Interactions

    VII. Concluding Remarks


    Neuronal Differentiation in Reaggregate Cell Cultures

    I. Introduction

    II. Aggregation

    III. Morphological Development

    IV. Biochemical Development

    V. Cell-Cell Interaction

    VI. Conclusion


    Locus Coeruleus

    I. Introduction

    II. Anatomy of the Locus Coeruleus

    III. Biochemistry and Immunocytochemistry

    IV. Efferents from the Locus Coeruleus

    V Efferents to the Locus Coeruleus

    VI. Pharmacology of the Locus Coeruleus Neurons

    VII. Physiology


    Structure of Electric Organ and Mammalian Acetylcholine Receptor Molecules

    I. Introduction

    II. Purification of the AcChR Molecule

    III. Physical Properties of the AcChR

    IV Subunit Structure of the AcChR: A Highly Conserved Complex of Homologous Subunits

    V The Shape of the AcChR Molecule

    VI. The AcChR: A Transmembrane Ion Gate


    Molecular Properties of Benzodiazepine Receptors

    I. Introduction

    II. Forms of Benzodiazepine Receptors

    III. Regulation of Neuronal Benzodiazepine Receptors

    IV Agonist-Antagonist Interactions at Neuronal Benzodiazepine Receptors

    V Solubilization and Affinity Labeling of Benzodiazepine Receptors

    VI. Conclusions


    Glial and Neuronal Na+, K+ Pump

    I. Introduction

    II. Cerebral Cortex Slices

    III. Fractions Enriched in Neuronal and Glial Structures

    IV Cultured Astrocytes

    V General Discussion: The Glial and Neuronal Na+,K+ Pump


    Section 2. Aging and Pathology

    Development, Maturation, and Aging of Synapses

    I. Concepts of Synaptic Organization

    II. Central Synapses

    III. Neurogenesis

    IV. Synaptogenesis

    V. Aging of Synapses


    Morphological Aspects of Brain Edema

    I. Introduction

    II. Increased Intracranial Pressure

    III. Blood Vessels in the Central Nervous System

    IV. Disruption of the Blood-Brain Barrier

    V. Other Alterations of the Cerebral Endothelium Associated with Brain Edema

    VI. Brain Edema

    VII. Possible Mechanisms of Dysfunction as a Result of Brain Edema

    VIII. Additional Information Regarding the Extracellular Space in the Myelinated Axons


    Cell Biological Aspects of Down's Syndrome

    I. Introduction

    II. Neurotransmitters and Down's Syndrome

    III. Enzyme Changes in Down's Syndrome

    IV Interferon

    V Neurophysiological Changes in Down's Syndrome



    Homogeneously Staining Regions and Double Minute Chromosomes, Prevalent Cytogenetic Abnormalities of Human Neuroblastoma Cells

    I. Introduction

    II. Establishment of Human Neuroblastoma in Cell Culture

    III. Neuroblastoma Cell Lines: Neuronal Characteristics

    IV Homogeneously Staining Regions and Double Minute Chromosomes in Human Neuroblastoma Cells

    V Homogeneously Staining Regions and Double Minute Chromosomes in Other Types of Tumors

    VI. Summary and Overview


    Section 3. Methodologies

    Isolation and Culture of Cells of the Dorsal Root Ganglia

    I. Introduction

    II. Research Objectives

    III. Approaches and Techniques

    IV. Development and Differentiation of Dissociated DRG in Culture

    V. Conclusions


    Growth Requirements of Neural Cells In Vitro

    I. Introduction

    II. Factors Influencing the Growth of Cells In Vitro

    III. Serum-Free Defined Media for Neural Cells

    IV. Conclusions


    Anterior Pituitary Cells in Culture: A Precise Assay System for Hypothalamic and Peripheral Hormones

    I. Introduction

    II. Preparation of Cell Culture

    III. Control of LH and FSH Secretion: Effect of LHRH, Sex Steroids, and Inhibin

    IV. Control of Prolactin Secretion

    V. Control of ACTH Secretion: Effect of Corticotropin Releasing Factor,

    α-Adrenergic Agents, and Glucocorticoids


    Intraocular Transplantation in Rodents: A Detailed Account of the Procedure and Examples of Its Use in Neurobiology with Special Reference to Brain Tissue Grafting

    I. Introduction

    II. Principal Experimental Paradigms Possible Using Intraocular Grafting

    III. Transplantation Procedure

    IV. In Vivo Observations

    V. Immunology of Anterior Chamber Grafts

    VI. The Nervous Plexus of the Host Iris; Denervation Procedures

    VII. Strategies for Obtaining Staged Fetal Material Suitable for Grafting in Rats

    VIII. Preparation of Fetal Brain and Spinal Cord Tissue for Intraocular Grafting

    IX. Ethical Considerations



Product details

  • No. of pages: 470
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: January 28, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9781483268156

About the Editors

Sergey Fedoroff

Leif Hertz

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