Advances in Cellular Neurobiology

Advances in Cellular Neurobiology

Volume 1

1st Edition - January 28, 1980

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  • Editors: Sergey Fedoroff, Leif Hertz
  • eBook ISBN: 9781483267876

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Advances in Cellular Neurobiology, Volume 1 discusses the topographical anatomy and functional relation of the brain and spinal cord. This book is divided into three main sections—cell differentiation and interaction, aging and pathology, and methodologies. The topics discussed include specializations of non-neuronal cell membranes in the vertebrate nervous system; effects of neurohormones on glial cells; cerebellar granule cells in normal and neurological mutants of mice; and age-related changes in neuronal and glial enzyme activities. The glial fibrillary acidic (GFA) protein in normal neural cells and in pathological conditions; in vitro behavior of isolated oligodendrocytes; and biochemical mapping of specific neuronal pathways are also deliberated in this text. This publication is intended for neurologists, but is also beneficial to students researching on the central nervous system.

Table of Contents

  • List of Contributors


    Section 1. Cell Differentiation and Interaction

    Specializations of Nonneuronal Cell Membranes in the Vertebrate Nervous System

    I. Introduction

    II. Gap Junctions

    III. Tight Junctions

    IV. Assemblies


    Effects of Neurohormones on Glial Cells

    I. Introduction

    II. Models for dial Cells

    III. Receptors for Putative Neurohormones

    IV. Events Secondary to Receptor Activation

    V. Conclusions


    Retrograde Axonal Transport

    I. Introduction

    II. Mechanism of Retrograde Axonal Transport

    III. Retrograde Transport of Materials Endogenous to the Neuron

    IV. Retrograde Transport of Materials Exogenous to the Neuron

    V. Functions of Retrograde Transport of Exogenous Materials

    VI. Conclusion


    Biochemical Characteristics of Individual Neurons

    I. Introduction

    II. Single-Cell Samples

    III. Cell Structure

    IV. Biochemical Components

    V. Conclusion


    Section 2. Aging and Pathology

    Cerebellar Granule Cells in Normal and Neurological Mutants of Mice

    I. Introduction

    II. Possible Effect of Purkinje Cells on Proliferation of Granule Cells

    III. Effect of dial Cells on Granule Cell Migration

    IV. Survival of Granule Cells in Mutant Mice (Staggerer and Weaver)

    V. Parallel Fiber-Purkinje Cell Synapses

    VI. Granule Cell Transmitter

    VII. Comments on the Use of Neurological Mutants as Model Systems


    Cell Generation and Aging of Nontransformed Glial Cells from Adult Humans

    I. Cell Generation and Aging

    II. Origin of Adult Human Glia-Like Cell Lines

    III. Theories about Cellular Aging

    IV. Basic Characteristics of Adult Human Glia-Like Cells In Vitro

    V. Relation between Cell Generation and Aging in Human Glia-Like Cells

    VI. Miniclone Analysis of Glia-Like Cells

    VII. Conclusions


    Age-related Changes in Neuronal and Glial Enzyme Activities

    I. General Introduction

    II. Neuron-Specific Enzymes

    III. Glia-Specific Enzymes

    IV. Enzymes Associated with Specific Cellular Processes


    Glial Fibrillary Acidic (GFA) Protein in Normal Neural Cells and in Pathological Conditions

    I. Introduction

    II. Biochemical Properties of GFA Protein

    III. Preparation of Antisera

    IV. Immunohistochemical Localization of GFA Protein in Adult CNS

    V. Gliogenesis

    VI. Astroglial Response to Injury

    VII. Astroglial Marker in Vitro

    VIII. Diagnosis of Brain Tumors


    Section 3. Methodologies

    In Vitro Behavior of Isolated Oligodendrocytes

    I. Introduction

    II. Isolation of Oligodendrocytes

    III. Oligodendrocyte Subpopulations

    IV. Culture of Oligodendrocytes

    V. Conclusions


    Biochemical Mapping of Specific Neuronal Pathways

    I. Introduction

    II. Techniques for Biochemical Classification of Neurons

    III. Identification of Interconnections between Neurons Using Different Transmitters


    Separation of Neuronal and Glial Cells and Subcellular Constituents

    I. Introduction

    II. Methods of Cell Isolation

    III. Subcellular CNS Fractions

    IV. New Isolation Techniques

    V. The Use of Cell Fractions


    Separation of Neurons and Glial Cells by Affinity Methods

    I. Introduction

    II. Techniques of Separation by Affinity Systems

    III. Ligands for Neural Cell Surfaces

    IV. Concluding Remarks


    Subject Index

Product details

  • No. of pages: 472
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 28, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9781483267876

About the Editors

Sergey Fedoroff

Leif Hertz

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