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Advances in Cellular Neurobiology - 1st Edition - ISBN: 9780120083015, 9781483267876

Advances in Cellular Neurobiology

1st Edition

Volume 1

Editors: Sergey Fedoroff Leif Hertz
eBook ISBN: 9781483267876
Imprint: Academic Press
Published Date: 28th January 1980
Page Count: 472
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Advances in Cellular Neurobiology, Volume 1 discusses the topographical anatomy and functional relation of the brain and spinal cord. This book is divided into three main sections—cell differentiation and interaction, aging and pathology, and methodologies. The topics discussed include specializations of non-neuronal cell membranes in the vertebrate nervous system; effects of neurohormones on glial cells; cerebellar granule cells in normal and neurological mutants of mice; and age-related changes in neuronal and glial enzyme activities. The glial fibrillary acidic (GFA) protein in normal neural cells and in pathological conditions; in vitro behavior of isolated oligodendrocytes; and biochemical mapping of specific neuronal pathways are also deliberated in this text. This publication is intended for neurologists, but is also beneficial to students researching on the central nervous system.

Table of Contents

List of Contributors


Section 1. Cell Differentiation and Interaction

Specializations of Nonneuronal Cell Membranes in the Vertebrate Nervous System

I. Introduction

II. Gap Junctions

III. Tight Junctions

IV. Assemblies


Effects of Neurohormones on Glial Cells

I. Introduction

II. Models for dial Cells

III. Receptors for Putative Neurohormones

IV. Events Secondary to Receptor Activation

V. Conclusions


Retrograde Axonal Transport

I. Introduction

II. Mechanism of Retrograde Axonal Transport

III. Retrograde Transport of Materials Endogenous to the Neuron

IV. Retrograde Transport of Materials Exogenous to the Neuron

V. Functions of Retrograde Transport of Exogenous Materials

VI. Conclusion


Biochemical Characteristics of Individual Neurons

I. Introduction

II. Single-Cell Samples

III. Cell Structure

IV. Biochemical Components

V. Conclusion


Section 2. Aging and Pathology

Cerebellar Granule Cells in Normal and Neurological Mutants of Mice

I. Introduction

II. Possible Effect of Purkinje Cells on Proliferation of Granule Cells

III. Effect of dial Cells on Granule Cell Migration

IV. Survival of Granule Cells in Mutant Mice (Staggerer and Weaver)

V. Parallel Fiber-Purkinje Cell Synapses

VI. Granule Cell Transmitter

VII. Comments on the Use of Neurological Mutants as Model Systems


Cell Generation and Aging of Nontransformed Glial Cells from Adult Humans

I. Cell Generation and Aging

II. Origin of Adult Human Glia-Like Cell Lines

III. Theories about Cellular Aging

IV. Basic Characteristics of Adult Human Glia-Like Cells In Vitro

V. Relation between Cell Generation and Aging in Human Glia-Like Cells

VI. Miniclone Analysis of Glia-Like Cells

VII. Conclusions


Age-related Changes in Neuronal and Glial Enzyme Activities

I. General Introduction

II. Neuron-Specific Enzymes

III. Glia-Specific Enzymes

IV. Enzymes Associated with Specific Cellular Processes


Glial Fibrillary Acidic (GFA) Protein in Normal Neural Cells and in Pathological Conditions

I. Introduction

II. Biochemical Properties of GFA Protein

III. Preparation of Antisera

IV. Immunohistochemical Localization of GFA Protein in Adult CNS

V. Gliogenesis

VI. Astroglial Response to Injury

VII. Astroglial Marker in Vitro

VIII. Diagnosis of Brain Tumors


Section 3. Methodologies

In Vitro Behavior of Isolated Oligodendrocytes

I. Introduction

II. Isolation of Oligodendrocytes

III. Oligodendrocyte Subpopulations

IV. Culture of Oligodendrocytes

V. Conclusions


Biochemical Mapping of Specific Neuronal Pathways

I. Introduction

II. Techniques for Biochemical Classification of Neurons

III. Identification of Interconnections between Neurons Using Different Transmitters


Separation of Neuronal and Glial Cells and Subcellular Constituents

I. Introduction

II. Methods of Cell Isolation

III. Subcellular CNS Fractions

IV. New Isolation Techniques

V. The Use of Cell Fractions


Separation of Neurons and Glial Cells by Affinity Methods

I. Introduction

II. Techniques of Separation by Affinity Systems

III. Ligands for Neural Cell Surfaces

IV. Concluding Remarks


Subject Index


No. of pages:
© Academic Press 1980
28th January 1980
Academic Press
eBook ISBN:

About the Editors

Sergey Fedoroff

Leif Hertz

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