Advances in Carbohydrate Chemistry and Biochemistry

Advances in Carbohydrate Chemistry and Biochemistry

1st Edition - November 21, 2013

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  • Editor: Derek Horton
  • eBook ISBN: 9780124081130
  • Hardcover ISBN: 9780124080935

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Since its inception in 1945, this serial has provided critical and informative articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

Key Features

  • Features contributions from leading authorities and industry experts
  • Informs and updates on all the latest developments in the field


Researchers in biochemistry, organic chemistry, medicinal chemistry and instrumentation methodology

Table of Contents

  • Obituaries 1. Stephen John Charles Angyal

    The Andrews Lectures



    List of Publications by S. J. Angyal

    Obituaries 2. John Grant Buchanan

    List of Publications by J. Grant Buchanan

    Obituaries 3. Saul Roseman

    Biosynthesis and Metabolism of Simple Sugars

    Biosynthesis of Mucin Glycoproteins and Brain Gangliosides

    Discovery of the Sialyltransferase Catalyzing the In Vitro Biosynthesis of Sialyl-Lactose

    Biosynthesis of Oligoglycosyl-Glycoproteins Studied at the Johns Hopkins University (1965–1970)

    Bacterial Phosphotransferase System (PTS) Studied at the Johns Hopkins University (1965–1985)

    Intercellular Adhesion and the “Fish Theory” from the Johns Hopkins University (1966–1972)

    Degradation of Chitin and Hexosamine Metabolism in the Sea World (1985–2011)



    Chapter 4. De novo asymmetric synthesis of the pyranoses: From monosaccharides to oligosaccharides



    I Introduction

    II Masamune–Sharpless Approach to the Hexoses

    III Danishefsky Hetereo-Diels–Alder Approach to Various Pyranoses

    IV MacMillan Iterative Aldol Approach to Various Pyranoses

    V Asymmetric Oxidative Biocatalytic Aldol Approach to Various Pyranoses

    VI Sharpless Dihydroxylation/Enzymatic Aldol Approach 2-Ketoses

    VII Non-De Novo Asymmetric Approaches to Pyranoses

    VIII O’Doherty De Novo Approach to Pyranoses



    Chapter 5. Recent advances toward the development of inhibitors to attenuate tumor metastasis via the interruption of lectin–ligand interactions



    I Introduction

    II Roles of Carbohydrates in Tumor Development

    III Roles of Lectins in Tumor Development

    IV Developing Anticancer Approaches by Targeting Tumor-Associated Carbohydrate–Lectin Systems

    V Conclusions


    Chapter 6. Bacterial cell-envelope glycoconjugates



    I Introduction

    II Surface-Layer Glycoproteins

    III Nonclassical Secondary Cell-Envelope Polysaccharides

    IV Structural Analysis

    V Cell-Envelope Glycan Biosynthesis

    VI Glycan Engineering and Applications

    VII Concluding Remarks


    Author Index

    Subject Index

Product details

  • No. of pages: 320
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: November 21, 2013
  • Imprint: Academic Press
  • eBook ISBN: 9780124081130
  • Hardcover ISBN: 9780124080935

About the Serial Volume Editor

Derek Horton

Affiliations and Expertise

The American University, Washington, DC, USA

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