Advances in Carbohydrate Chemistry and Biochemistry, Volume 50

• Preface
• Robert Stuart Tipson: 1906–1991
• How Emil Fischer was Led to the Lock and Key Concept for Enzyme Specificity
  • I INTRODUCTION
  • II ASYMMETRIC INDUCTION
  • III YEAST FERMENTATIONS AND ENZYMES
  • IV THE LOCK AND KEY CONCEPT
  • V INSIGHTS ON ENZYME SPECIFICITY
  • VI CONCLUDING REMARKS
• Anomeric-Oxygen Activation for Glycoside Synthesis: The Trichloroacetimidate Method
  • I GENERAL INTRODUCTION TO GLYCOSIDE SYNTHESIS: ACTIVATION THROUGH ANOMERIC OXYGEN-EXCHANGE REACTIONS
  • II ANOMERIC-OXYGEN ACTIVATION: ANOMERIC O-ALKYLATION
  • III ANOMERIC-OXYGEN ACTIVATION: THE TRICHLOROACETIMIDATE METHOD
  • IV OTHER ANOMERIC-OXYGEN ACTIVATION METHODS
  • V CONCLUSIONS
  • ACKNOWLEDGMENTS
• Synthetic Reactions of Aldonolactones
  • I INTRODUCTION
  • II ACETALATION AND ALDONOLACTONES
  • III ACYLATION AND ETHERIFICATION OF ALDONOLACTONES
  • IV REACTION OF ALDONOLACTONES WITH HYDROGEN BROMIDE
  • V CHAIN ELONGATION THROUGH THE ALDONOLACTONE CARBONYL GROUP
  • VI REACTION OF ALDONOLACTONES WITH ALCOHOLS
  • VII REACTION OF ALDONOLACTONES WITH AMMONIA AND RELATED NUCLEOPHILES
  • VIII REDUCTION OF ALDONOLACTONES
  • IX β-ELIMINATION REACTIONS
  • X SYNTHESIS OF DEOXY SUGARS FROM ALDONOLACTONES
  • XI GLYCOSYLATION OF ALDONOLACTONES
  • XII ALDONOLACTONES AS CHIRAL PRECURSORS FOR THE SYNTHESIS OF NATURAL PRODUCTS
• Molecular Structure of Lipid a, the Endotoxic Center of Bacterial Lipopolysaccharides
  • I INTRODUCTION
  • II LIPID A: DEFINITION AND GENERAL PROPERTIES
  • III PRIMARY STRUCTURE OF LIPID A : BACKBONE, POLAR SUBSTITUENTS, AN FATTY ACIDS
  • IV SYNTHETIC LIPID A
  • V CONFORMATION OF LIPID A
  • VI ENDOTOXOCITY OF LPS AND LIPID A
  • VII SEROLOGY OF LIPID A
  • VIII SYNOPSIS: THE STRUCTURE, ACTIVITY, AND FUNCTION OF LIPID A
  • ACKNOWLEDGMENTS
• Developments in the Synthesis of Glycopeptides Containing Glycosyl l-Asparagine, l-Serine, and l-Threonine
  • I INTRODUCTION
  • II N-GLYCOPEPTIDES
  • III 3-O-GLYCOPEPTIDES OF l-SERINE OR l-THREONINE
  • IV BINDING OF GLYCOPEPTIDES TO PROTEINS
  • V SOLID-PHASE SYNTHESIS
  • VI ENZYMES AS TOOLS FOR GLYCOPEPTIDE SYNTHESIS
  • VII ADDENDUM
• Physicochemical Analyses of Oligosaccharide Determinants of Glycoproteins
  • I INTRODUCTION
  • II METHODS OF STRUCTURAL ANALYSIS
  • III PURIFICATION AND PROFILING
  • IV BACKBONES AND CORE REGIONS OF N- AND O-LINKED CHAINS OF SECRETED AND PLASMA MEMBRANE GLYCOPROTEINS
  • V PERIPHERAL SUBSTITUTIONS OF N- AND O-LINKED CHAINS OF GLYCOPROTEINS
  • VI THE CONFORMATIONS AND MOLECULAR RECOGNITION OF CARBOHYDRATE DETERMINANTS DISTANT FROM THE PROTEIN OLIGOSACCHARIDE CORE OF GLYCOPROTEINS
  • VII THE CONFORMATIONS AND MOLECULAR RECOGNITION OF CARBOHYDRATE DETERMINANTS ADJACENT TO THE PROTEIN MOIETY OF GLYCOPROTEINS
  • ACKNOWLEDGMENTS
• Author Index for Volume 50
• Subject Index for Volume 50
• Cumulative Author Index for Vols. 46–50
• Cumulative Subject Index for Vols. 46–50

Since its inception in 1945, this serial has provided critical articles by research specialists in the industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.