Volume 70 begins with two "Foundations in Cancer Research" articles, a staple of the Advances in Cancer Research series. The first article by Michael Stoker presents a review of some of the early advances made by cancer cell biology researchers. The second article by Emmanuel Farber describes the methods by which researchers delineate the phenotype of cells and ways to alter these phenotypes to prevent or delay carcinomas. Chidambaram and Dean illustrate the tumors and associated malformations of nevoid basal cell carcinoma. Koli and Keski-Oja review the effects of how transforming growth factor-b regulates cell proliferation, differentiation, and morphogenesis and its regulation by the steroid hormone superfamily. Jean-Marc Lemaitre and colleagues discuss the involvement of protooncogenes in the control of the cell cycle and embryonic development with specific attention paid to c-Myc expression and c-Myc function. A review of the various studies involving tumor-infiltrating lymphocytes and their possible role in cancer prevention is presented by Steven Rosenberg and co-workers. Finally, Bruce Ponder and Darrin Smith review the genetic and biological aspects of multiple endocrine neoplasia type-2 syndromes and the phenotypes associated with ret mutations.


Researchers and students in basic and clinical science of cancer biology and oncology, plus related areas in genetics, immunology, virology, cell biology, and molecular biology.

Table of Contents

Foundations in Cancer Research: M. Stoker, Fundamentals of Cancer Cell Biology: Introduction. Antecedents. Autobiographical Note. Foundations of Tissue Culture. Foundations of Cell Culture. Clones. The Immortals: Stable Cell Lines. The Mortals: Cell Strains. Food for Cells in Culture. Growth Factors. Short-Range Cell Interactions. Junctional Communication. Cell and Substrate Adhesion. The Tumor Viruses. Cell Fusion. Conclusion. References. E. Farber, The Step-by-Step Development of Epithelial Cancer: From Phenotype to Genotype: Cancer Development as Basic to Cancer Research. Patterns of Development of Epithelial Cancers. A Working Hypothesis. The Phenotypes. The Genotypes. The Challenge. References. A. Chidambaram and M. Dean, Genetics of the Nevoid Basal Cell Carcinoma Syndrome: Introduction. Clinicopathological Features of NBCCS. Genetics of NBCCS. Strategies for Isolation of Candidate Genes. Discussion. References. K. Koli and J. Keski-Oja, Transforming Growth Factor-( System and Its Regulation by Members of the Steroid-Thyroid Hormone Superfamily: Introduction. Transforming Growth Factor-(. Dual Effects of TGF-(on Cell Proliferation. Regulation of Cell Differentiation by TGF-(. TGF-(in the Regulation of the Immune System. The Steroid-Thyroid Hormone Superfamily. Steroid Hormone Regulation of TGF-( Isoform Expression. Regulation of Pl


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© 1996
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@qu:"This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." @source:--AMERICAN SCIENTIST @qu:"Excellent, highly informative, in-depth reviews... expertly written, up-to-date, and well-referenced." @source:--JOURNAL OF MEDICINAL CHEMISTRY