
Advances in Cancer Research
Description
Key Features
- Provides information on cancer research
- Outstanding and original reviews
- Suitable for researchers and students
Readership
Table of Contents
- 1. The Evolving, Multifaceted Roles of Autophagy In Cancer
Jennifer Liu and Jayanta Debnath
2. Inhibitors of DNA Methylation, Histone Deacetylation and Histone Demethylation: A Perfect Combination for Cancer Therapy
Cynthia A. Zahnow, Michael Topper, Meredith Stone, Tracy Murray-Stewart, Huili Li, Stephen B. Baylin, and Robert A. Casero, Jr.
3. Emerging Roles of Epigenetic Regulator Sin3 in Cancer
Nidhi Bansal, Gregory David, Eduardo Farias and Samuel Waxman
4. PAKs in Human Cancer Progression – From Inception to Therapeutic to Future Oncobiology
Rakesh Kumar and Da-Qiang Li
5. Sirtuins and the Estrogen Receptor as Regulators of the Mammalian Mitochondrial UPR in Cancer and Aging
Doris Germain
6. Keratinocyte Carcinoma as a Marker of a High Cancer-Risk Phenotype
James Small, Virginia Barton, Brett Peterson and Anthony J. Alberg
Product details
- No. of pages: 312
- Language: English
- Copyright: © Academic Press 2016
- Published: March 29, 2016
- Imprint: Academic Press
- Hardcover ISBN: 9780128047897
- eBook ISBN: 9780128051818
About the Serial Editors
Kenneth Tew

The Tew laboratory maintains an interest in using redox pathways as a platform to develop therapeutic strategies through drug discovery/development and biomarker identification. We interrogate how reactive oxygen and nitrogen species (ROS/RNS) impact cancer cells and develop novel drugs that impact on glutathione based pathways. Our research efforts have been integral to studies that have identified glutathione S-transferases (GST) as important in drug resistance, catalytic detoxification and as arbiters of kinase-mediated cell signaling events. In addition, we have been instrumental in defining how GSTP contributes to the process by which cells respond to ROS by selective addition of glutathione to specific protein clusters, so called S-glutathionylation. Each of these research areas has had broad impact on a number of cancer disciplines. Moreover, we have also been seminally involved in the Phase I to III clinical testing of three oncology drugs, Telcyta, Telintra and NOV-002. Other ongoing translational efforts have produced two ongoing clinical trials to measure the effectiveness of serum S-glutathionylated serine proteinase inhibitors as possible biomarkers for exposure to hydrogen peroxide mouthwashes and radiation.
Affiliations and Expertise
Paul Fisher
