Advances in Cancer Research, Volume 119

1st Edition

Hardcover ISBN: 9780124071902
eBook ISBN: 9780124072114
Imprint: Academic Press
Published Date: 5th July 2013
Page Count: 504
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Table of Contents


Chapter One. Understanding the Role of ETS-Mediated Gene Regulation in Complex Biological Processes

1 Introduction

2 Modulation of ETS Function

3 Defining and Characterizing ETS Target Genes

4 ETS and MicroRNA

5 ETS Mouse Knockout and Mutant Models

6 ETS Factors and Cancer

7 The Role of ETS Factors in the Microenvironment

8 ETS Factors and Other Diseases

9 Targeting the ETS Network

10 Concluding Remarks



Chapter Two. Advances in Understanding the Coupling of DNA Base Modifying Enzymes to Processes Involving Base Excision Repair


1 Introduction

2 Enzymes That Modify Bases in DNA

3 The Removal of Enzymatically Modified Bases by BER

4 Relationships Between the Activity of Base Modifying Enzymes and DNA Repair

5 Summary



Chapter Three. Role of Oxidative Stress and the Microenvironment in Breast Cancer Development and Progression

1 Oxidative Stress Changes the Breast Tumor Microenvironment

2 Oxidative Stress Regulate Caveolin-1 Signaling and Energy Metabolism in the Tumor Microenvironment

3 Oxidative Stress Causes Fibroblasts to Undergo Senescence and Induces Mitochondrial Dysfunction

4 Conclusions and Future Perspectives—Should We Target Breast Cancer Stroma?


Chapter Four. Mitochondrial Alterations During Carcinogenesis: A Review of Metabolic Transformation and Targets for Anticancer Treatments

1 An Overview of the Role of Mitochondria in Cancer

2 Alterations in Energy Metabolism in Cancer Cells

3 Oncogenes and Tumor Suppressors Involved in Mitochondrial Function

4 Mitochondria as the Key Organelles Involved in Cell Death and Survival

5 Cancer Metastasis: Implication of Mitochondrial Metabolism in the Adapt


Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.


Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology.


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© Academic Press 2013
Academic Press
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Praise for the Serial
"This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." --American Scientist
"Excellent, highly informative, in-depth reviews…expertly written, up-to-date, and well-referenced." --Journal of Medicinal Chemistry
"This is a series that has a long tradition of excellence in the field of cancer biology." --Doody’s Publishing Reviews