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Advances in Cancer Research - 1st Edition - ISBN: 9780124016767, 9780124016835

Advances in Cancer Research, Volume 120

1st Edition

AEG-1/MTDH/Lyric Implicated in Multiple Human Cancers

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Serial Volume Editor: Devanand Sarkar
Hardcover ISBN: 9780124016767
eBook ISBN: 9780124016835
Imprint: Academic Press
Published Date: 12th August 2013
Page Count: 264
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Table of Contents

Chapter One. AEG-1/MTDH/LYRIC, the Beginning: Initial Cloning, Structure, Expression Profile, and Regulation of Expression

  • 1 Introduction
  • 2 Initial Cloning
  • 3 Structure of AEG-1/MTDH/LYRIC
  • 4 Evolution of AEG-1/MTDH/LYRIC
  • 5 Expression Profile
  • 6 Regulation of Gene Expression
  • 7 Concluding Remarks
  • Acknowledgments
  • References

Chapter Two. AEG-1/MTDH/LYRIC: Clinical Significance

  • 1 Introduction
  • 2 Gastrointestinal System
  • 3 Genitourinary System
  • 4 Nervous System
  • 5 Respiratory System: Nonsmall Cell Lung Cancer
  • 6 Head and Neck Cancer
  • 7 Osteosarcoma
  • 8 Lymphoma
  • 9 Anti-AEG-1/MTDH/LYRIC Antibody as a Biomarker for Cancer
  • 10 Clinical Significance of AEG-1/MTDH/LYRIC Polymorphism
  • 11 Conclusion
  • Acknowledgments
  • References

Chapter Three. AEG-1/MTDH/LYRIC: Signaling Pathways, Downstream Genes, Interacting Proteins, and Regulation of Tumor Angiogenesis

  • 1 Introduction
  • 2 Cloning of AEG-1/MTDH/LYRIC
  • 3 AEG-1/MTDH/LYRIC: High Expression Is Linked to Cancer Aggressiveness
  • 4 AEG-1/MTDH/LYRIC: Signaling Pathways
  • 5 AEG-1/MTDH/LYRIC: Downstream Molecules and Interacting Proteins
  • 6 AEG-1/MTDH/LYRIC and Angiogenesis
  • 7 Conclusion and Future Perspectives
  • Acknowledgments
  • References

Chapter Four. Pleiotropic Roles of AEG-1/MTDH/LYRIC in Breast Cancer

  • 1 Introduction
  • 2 Aberrations of AEG-1/MTDH/LYRIC in Breast Cancer
  • 3 Variants of AEG-1/MTDH/LYRIC in Breast Cancer
  • 4 Regulation of AEG-1/MTDH/LYRIC in Breast Cancer
  • 5 AEG-1/MTDH/LYRIC in Breast Cancer Growth Control
  • 6 AEG-1/MTDH/LYRIC and EMT in Breast Cancer
  • 7 AEG-1/MTDH/LYRIC and Breast Cancer Metastasis
  • 8 AEG-1/MTDH/LYRIC and Chemoresistance
  • 9 Molecular Understanding of AEG-1/MTDH/LYRIC
  • 10 Therapeutic Targeting of AEG-1/MTDH/LYRIC
  • 11 Concluding Remarks and Future Perspectives
  • References

Chapter Five. Drug Resistance Mediated by AEG-1/MTDH/LYRIC

  • 1 Introduction: AEG-1/MTDH/LYRIC, a Gene Involved in Cancer Metastasis and Drug Resistance
  • 2 Mechanisms of AEG-1/MTDH/LYRIC-Mediated Drug Resistance
  • 3 AEG-1/MTDH/LYRIC Downstream Genes Identified by Microarray
  • 4 Potential Contribution of Genes Located Near AEG-1/MTDH/LYRIC on Chromosome 8q22 Locus to Cancer Drug Resistance
  • 5 Conclusions and Future Perspectives
  • Acknowledgments
  • References

Chapter Six. The Role of AEG-1/MTDH/LYRIC in the Pathogenesis of Central Nervous System Disease

  • 1 Introduction
  • 2 The Role of AEG-1/MTDH/LYRIC in CNS Disease Pathogenesis
  • 3 Structure and Localization of Astrocyte-Elevated Gene-1 in the CNS
  • 4 The Role of AEG-1/MTDH/LYRIC in Brain Tumor Pathogenesis
  • 5 Conclusions
  • References

Chapter Seven. AEG-1/MTDH/LYRIC in Liver Cancer

  • 1 Hepatocellular Carcinoma: Etiology, Epidemiology, and Pathogenesis
  • 2 HCC: The Molecular Abnormalities
  • 3 AEG-1/MTDH/LYRIC is Overexpressed in HCC
  • 4 Biological Consequence of AEG-1/MTDH/LYRIC Overexpression in HCC
  • 5 AEG-1/MTDH/LYRIC Downstream Genes
  • 6 AEG-1/MTDH/LYRIC-Interacting Proteins
  • 7 The Role of AEG-1/MTDH/LYRIC in Hepatocarcinogenesis: Novel Insights from a Mouse Model
  • 8 Conclusion
  • References


Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume covers AEG-1/MTDH/Lyric implicated in multiple human cancers.

Key Features

  • Provides information on cancer research
  • Outstanding and original reviews
  • Suitable for researchers and students


Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology.


No. of pages:
© Academic Press 2013
12th August 2013
Academic Press
Hardcover ISBN:
eBook ISBN:


Praise for the Serial
"This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." --American Scientist
"Excellent, highly informative, in-depth reviews…expertly written, up-to-date, and well-referenced." --Journal of Medicinal Chemistry
"This is a series that has a long tradition of excellence in the field of cancer biology." --Doody’s Publishing Reviews

Ratings and Reviews

About the Serial Volume Editor

Devanand Sarkar