Advances in Cancer Research, Volume 120

1st Edition

AEG-1/MTDH/Lyric Implicated in Multiple Human Cancers

Serial Volume Editors: Devanand Sarkar
Hardcover ISBN: 9780124016767
eBook ISBN: 9780124016835
Imprint: Academic Press
Published Date: 12th August 2013
Page Count: 264
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Table of Contents

  • Contributors
  • Preface
  • Chapter One. AEG-1/MTDH/LYRIC, the Beginning: Initial Cloning, Structure, Expression Profile, and Regulation of Expression
    • 1 Introduction
    • 2 Initial Cloning
    • 3 Structure of AEG-1/MTDH/LYRIC
    • 4 Evolution of AEG-1/MTDH/LYRIC
    • 5 Expression Profile
    • 6 Regulation of Gene Expression
    • 7 Concluding Remarks
    • Acknowledgments
    • References

  • Chapter Two. AEG-1/MTDH/LYRIC: Clinical Significance
    • 1 Introduction
    • 2 Gastrointestinal System
    • 3 Genitourinary System
    • 4 Nervous System
    • 5 Respiratory System: Nonsmall Cell Lung Cancer
    • 6 Head and Neck Cancer
    • 7 Osteosarcoma
    • 8 Lymphoma
    • 9 Anti-AEG-1/MTDH/LYRIC Antibody as a Biomarker for Cancer
    • 10 Clinical Significance of AEG-1/MTDH/LYRIC Polymorphism
    • 11 Conclusion
    • Acknowledgments
    • References

  • Chapter Three. AEG-1/MTDH/LYRIC: Signaling Pathways, Downstream Genes, Interacting Proteins, and Regulation of Tumor Angiogenesis
    • 1 Introduction
    • 2 Cloning of AEG-1/MTDH/LYRIC
    • 3 AEG-1/MTDH/LYRIC: High Expression Is Linked to Cancer Aggressiveness
    • 4 AEG-1/MTDH/LYRIC: Signaling Pathways
    • 5 AEG-1/MTDH/LYRIC: Downstream Molecules and Interacting Proteins
    • 6 AEG-1/MTDH/LYRIC and Angiogenesis
    • 7 Conclusion and Future Perspectives
    • Acknowledgments
    • References

  • Chapter Four. Pleiotropic Roles of AEG-1/MTDH/LYRIC in Breast Cancer
    • 1 Introduction
    • 2 Aberrations of AEG-1/MTDH/LYRIC in Breast Cancer
    • 3 Variants of AEG-1/MTDH/LYRIC in Breast Cancer
    • 4 Regulation of AEG-1/MTDH/LYRIC in Breast Cancer
    • 5 AEG-1/MTDH/LYRIC in Breast Cancer Growth Control
    • 6 AEG-1/MTDH/LYRIC and EMT in Breast Cancer</LI


Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume covers AEG-1/MTDH/Lyric implicated in multiple human cancers.

Key Features

  • Provides information on cancer research
  • Outstanding and original reviews
  • Suitable for researchers and students


Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology.


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© Academic Press 2013
Academic Press
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Praise for the Serial
"This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." --American Scientist
"Excellent, highly informative, in-depth reviews…expertly written, up-to-date, and well-referenced." --Journal of Medicinal Chemistry
"This is a series that has a long tradition of excellence in the field of cancer biology." --Doody’s Publishing Reviews

About the Serial Volume Editors

Devanand Sarkar Serial Volume Editor