- 113th volume of Advances in Cancer Research
- Expert authors
- Chapters on topics including microRNA regulatory network, multifaceted oncoprotein tax, and underlying chromosomal translocations
Table of Contents
- The AID dilemma: infection, or cancer?
- The microRNA regulatory network in normal- and HTLV-1-transformed T cells
- The multifaceted oncoprotein Tax: Sub-cellular localization, post-translational modifications and NF-κB activation
- Lynch or not Lynch? Is that always a question?
- Activation induced deaminase in antibody diversification and chromosome translocation
- Opportunities and challenges in tumor angiogenesis research: back and forth between bench and bed
- Molecular Logic Underlying Chromosomal Translocations, Random or non-Random?
Tasuku Honjo, Maki Kobayashi, Nasim Begum, Ai Kotani, Somayeh Sabouri, and Hitoshi Nagaoka
Donna M. D’Agostino, Paola Zanovello, Toshiki Watanabe and Vincenzo Climinale
Youmna Kfoury, Rihab Nasr, Chloé Journo, Renaud Mahieux, Claudine Pique and Ali Bazarbachi
Chrystelle Colas, Florence Coulet, Magali Svrcek, Ada Collura, Jean-François Fléjou, Alex Duval and Richard Hamelin
Anna Gazumyan, Anne Bothmer, Isaac A. Klein, Michel C Nussenzweig and Kevin M. McBride
Li Qin, Jennifer L. Bromberg-White, and Chao-Nan Qian
Chunru Lin, Liuqing Yang and Michael G. Rosenfeld
- No. of pages: 304
- Language: English
- Copyright: © Academic Press 2012
- Published: March 30, 2012
- Imprint: Academic Press
- eBook ISBN: 9780123978417
- Hardcover ISBN: 9780123942807
About the Serial Editors
The Tew laboratory maintains an interest in using redox pathways as a platform to develop therapeutic strategies through drug discovery/development and biomarker identification. We interrogate how reactive oxygen and nitrogen species (ROS/RNS) impact cancer cells and develop novel drugs that impact on glutathione based pathways. Our research efforts have been integral to studies that have identified glutathione S-transferases (GST) as important in drug resistance, catalytic detoxification and as arbiters of kinase-mediated cell signaling events. In addition, we have been instrumental in defining how GSTP contributes to the process by which cells respond to ROS by selective addition of glutathione to specific protein clusters, so called S-glutathionylation. Each of these research areas has had broad impact on a number of cancer disciplines. Moreover, we have also been seminally involved in the Phase I to III clinical testing of three oncology drugs, Telcyta, Telintra and NOV-002. Other ongoing translational efforts have produced two ongoing clinical trials to measure the effectiveness of serum S-glutathionylated serine proteinase inhibitors as possible biomarkers for exposure to hydrogen peroxide mouthwashes and radiation.
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