The presentation of Foundations in Cancer Research articles has become a focal point of the Advances in Cancer Research series. This volume begins with two such timely reviews, the first of which is by series co-editor George Klein. Dr. Klein evaluates and reviews Leslie Foulds' suggestion that tumors develop in a series of steps and the effect that this 40-year-old hypothesis has had on cancer research. The second Foundations article by L.A. Loeb presents the historical significance of increased mutagenesis and clonal selection on tumor progression. The first regular article, by R. Khosravi-Far and colleagues, analyzes the functional role of Ras in signal transduction and the involvement that Rho family proteins have on Ras. Mark Saville and Roger Watson review supporting evidence that B-Myb may be a critical regulator of the cell cycle. S. Baylin and co-authors compare DNA methylation in normal cells with that in cancerous cells and discuss the specific consequences associated with tumor progression. Last, Steven Grant discusses the use of ara-C as a treatment for various types of cancer and summarizes its cellular metabolism, mode of action and resistance, and the molecular events involved in apoptosis.
Researchers and students in basic and clinical science of cancer biology and oncology, plus related areas in genetics, immunology, virology, cell biology, and molecular biology.
G. Klein, Foulds Dangerous Idea Revisited: The Multistep Development of Tumors 40 Years Later.
L.A. Loeb, Cancer Cells Exhibit a Mutator Phenotype.
R. Khosravi-Far, S. Campbell, K.L. Rossman, and C.J. Der, Increasing Complexity of Ras Signal Transduction: Involvement of Rho Family Proteins.
M. Saville and R. Watson, B-Myb: A Key Regulator of the Cell Cycle.
S.B. Baylin, J.G. Herman, J.R. Graff, P.M. Vertino, and J.-P. Issa, Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia.
S. Grant, Ara-C: Cellular and Molecular Pharmacology.
- No. of pages:
- © Academic Press 1998
- 8th October 1997
- Academic Press
- eBook ISBN:
- Hardcover ISBN:
@from:Praise for the Serial @qu:"This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." @source:--AMERICAN SCIENTIST @qu:"Excellent, highly informative, in-depth reviews... expertly written, up-to-date, and well-referenced." @source:--JOURNAL OF MEDICINAL CHEMISTRY