List of contributors. Preface. 1. Neuroanatomy of the brain vasopressin systems. 1. Anatomy and function of extrahypothalamic vasopressin systems in the brain (G.J. De Vries, M.A. Miller). 1.2. Functions of the perikaryon and dendrites in magnocellular vasopressin-secreting neurons. New insights from ultrastructural studies (J.F. Morris, T.C. Budd, M.J. Epton, D. Ma, D.V. Pow, H. Wang). 1.3. Functional neuroanatomy of the parvocellular vasopressinergic system: transcriptional responses to stress and glucocorticoid feedback (K.J. Kovács). 1.4. Vasopressin binding sites in the central nervous system: distribution and regulation (E. Tribollet, Y. Arsenijevic, C. Barberis). 2. Cellular properties of vasopressinergic neurons. 2.1. Electrophysiological properties. 2.1.1. Osmoregulation of vasopressin neurons: a synergy of intrinsic and synaptic processes (C.W. Bourque). 2.1.2. Neurophysiology of magnocellular neuroendocrine cells: recent advances (G.I. Hatton, Z.-H. Li). 2.1.3. Phenotypic and state-dependent expression of the electrical and morphological properties of oxytocin and vasopressin neurones (W.E. Armstrong, J.E. Stem). 2.2. Cell and molecular biology of vasopressin neurons. 2.2.1. The magnocellular neurons of the hypothalamo-neurohypophyseal system display remarkable neuropeptidergic phenotypes leading to novel insights in neuronal cell biology (F.W. Van Leeuwen, R.W.H. Verwer, H. Spence, D.A.P. Evans, J.P.H. Burbach). 2.2.2. Biochemistry of vasopressin fragments (J.P.H. Burbach, 0. Schoots, F. Hernando). 2.2.3. Regulation of the synthesis and secretion of vasopressin (D. Murphy, S. Waller, K. Fairhall, D.A. Carter and I.C.A.F. Robinson). 3. Cellular actions of vasopressin. 3.1. Molecular actions and responses to vasopressin. 3.1.1. Signal transduction pathways of the human V1-vascular, V2-renal, V3-pituitary vasopressin and oxytocin receptors
Advances in Brain Vasopressin elucidates the functions of the regulatory peptide vasopressin in the nervous system, and reviews the current status of this field at different levels.
It deals with the cell biology and anatomy of the neurons that produce vasopressin in the brain, and provides an overview on the receptors of vasopressin and the signal transduction pathways that they activate, including the cellular responses that are triggered by vasopressin. Reviews are presented on the modulation of behavior induced by vasopressin in a number of different contexts, such as sex-linked and steroid-dependent behaviors, social behaviors, and learning and memory.
Furthermore, the volume deals with several controversial issues in the field by presenting overlapping chapters from different research groups in order to provide the reader with current views.
Highly relevant and useful, for those working on this "first" neuropeptide, and for young investigators entering the field, and in addition, shows how important a multidisciplinary approach is to unravelling the function of a neuropeptide in the brain.
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- © Elsevier Science 1998
- 16th February 1999
- Elsevier Science
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Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands