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Chapter One: Could Titanium Dioxide Nanotubes Represent a Viable Support System for Appropriate Cells in Vascular Implants?
- 1 Introduction
- 2 Selected Clinical Conditions Associated With Vessel Implants
- 3 Types of Vascular Implants
- 4 Nanotopography, Surface Modifications, and Biocompatibility of Implants
- 5 TiO2 Nanotubes
- 6 Surface Modification of TiO2 Nanotubes
- 7 Interaction of TiO2 Nanotubes With Cells
- 8 Antiinfective Properties of TiO2 Nanotubes
- 9 Concluding Remarks and Perspectives
Chapter Two: Ras Proteolipid Nanoassemblies on the Plasma Membrane Sort Lipids With High Selectivity
- 1 Ras Proteins Are Lipid-Anchored and Form Nanoclusters on Cell Plasma Membrane
- 2 Ras Nanoclusters Act as Nanoswitches to Transiently Regulate MAPK Signal Transduction
- 3 Ras Nanoclusters Preferences for Ordered vs Disordered Domains in Cell PM
- 4 Acidic Lipid Selectivity of Ras Nanoclusters
- 5 Perturbation of Ras Nanoclusters Alters Ras Effector Binding and Signaling
- 6 Conclusion
Chapter Three: Membrane-Mimetic Inverse Bicontinuous Cubic Phase Systems for Encapsulation of Peptides and Proteins
- 1 Inverse Bicontinuous Cubic Phases
- 2 Peptide and Protein Encapsulation: Understanding the Structural Relationship Between Guest Molecules and the Cubic Phase
- 3 Lipid Packing, Interfacial Curvature, and Lateral Pressure
- 4 Applications of Bicontinuous Cubic Phases for Protein or Peptide Encapsulation
- 5 Cubic Phase Nanoparticles (Cubosomes)
- 6 Characterization of Bicontinuous Cubic Phase-Peptide/Protein Systems
- 7 Conclusion
Chapter Four: Interactions of Flavonoids With Lipidic Mesophases
- 1 Introduction
- 2 Flavonoids Interacting With Planar Membranes
- 3 Flavonoids Interacting With Curved Membranes
- 4 Conclusions
Chapter Five: Preparation and Characterization of Supported Lipid Bilayers for Biomolecular Interaction Studies by Dual Polarization Interferometry
- 1 Introduction
- 2 Dual Polarization Interferometry
- 3 Experimental Protocols for Solid-Supported Membranes in DPI Analysis
- 4 Changes in Lipid Molecular Organization in Relation to the Solute–Membrane Interaction
- 5 Summary and Outlook
Chapter Six: Gold Nanomaterials: Recent Advances in Cancer Theranostics
- 1 Introduction to Different Forms of Gold Nanomaterials
- 2 Synthesis of Different Forms of Gold Nanomaterials
- 3 Diagnostic and Imaging Applications of Gold Nanomaterials
- 4 Therapeutic and Drug Delivery Applications of Gold Nanomaterials
- 5 Conclusion and Perspectives
Advances in Biomembranes and Lipid Self-Assembly, formerly titled Advances in Planar Lipid Bilayers and Liposomes, provides a global platform for a broad community of experimental and theoretical researchers studying cell membranes, lipid model membranes, and lipid self-assemblies from the micro- to the nanoscale. Planar lipid bilayers are widely studied due to their ubiquity in nature, also finding application in the formulation of biomimetic model membranes. Section topics in this release cover Ras Proteolipid nano-assemblies on the plasma membrane, gold nanomaterials, recent advances in cancer theranostics, and the interactions of flavonoids with lipidic mesophases, amongst other highly resourceful topics.
Self-assembled lipid structures have enormous potential as dynamic materials, ranging from artificial lipid membranes, to cell membranes, from biosensing, to controlled drug delivery, and from pharmaceutical formulations, to novel food products, to name a few. This series represents both original research and comprehensive reviews written by world-leading experts and young researchers.
- Surveys recent theoretical and experimental results on lipid micro- and nanostructures
- Presents potential uses of applications, like clinically relevant diagnostic and therapeutic procedures, biotechnology, pharmaceutical engineering, and food products
- Includes both original research and comprehensive reviews written by world leading experts and young researchers
- Provides a global platform for a broad community of experimental and theoretical researchers studying cell membranes, lipid model membranes, and lipid self-assemblies, from micro- to nanoscale
experts in the field of chemistry, physics and biology of lipid micro- and nanostructures and biological membranes, and a podium for non-specialists working on the interdisciplinary front
- No. of pages:
- © Academic Press 2017
- 22nd March 2017
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
Aleš Iglič received his B.Sc. and Ph.D. degrees in physics and M.Sc. degree in biophysics from the Department of Physics, and the Ph.D. degree in electrical engineering from the Faculty of Electrical Engineering, all from the University of Ljubljana. He is a Full Professor and the Head of Laboratory of Biophysics of the Faculty of Electrical Engineering at University of Ljubljana. His main research interests are in electrostatics, mechanics and statistical physics of lipid nanostructures and biological membranes. He is devoted to higher education, basic research in biophysics and close contacts to clinical practice. Prof. Iglič was visiting scientist and professor at Åbo Academy University in Turku (Finland), Friedrich Schiller University in Jena (Germany) and Czech Technical University in Prague (Czech Republic). He established collaborations with researchers from different universities across the Europe, USA and India and was supervisor of many M.Sc., Ph.D. and postdoctoral students from Slovenia, Czech Republic, Poland, Iran, Bulgaria, Germany, India and Israel. Since 2009 is the editor of Elsevier book series »Advances in Planar Lipid Bilayers and Liposomes« (APLBL).
Faculty of Electrical Engineering, University of Ljubljana, Slovenia
Ana Garcia-Saez gained her PhD at the Department of Biochemistry and Molecular Biology, University of Valencia, Spain in 2005, and then worked as a Post-doc at BioTec, TU Dresden, Germany. Since 2013, she has been working as a professor at the Interfaculty Institute for Biochemistry (IFIB), Universität Tübingen, Germany. Since 2010, Ana was also the Max Planck Research Group’s Leader and the Deutsches Krebsforschungzentrum (DKFZ) Junior Group’s Leader at Bioquant, Heidelberg, Germany, from 2010 to 2013, and has been a Young Investigator as part of the EMBO Young Investigator Programme since 2017. Ana Garcia-Saez’s research areas include Cell Death & Biophysics, Molecular and Cellular Biology, and Biochemistry & Advanced Microscopy. Though she is also involved in and takes an active interest in Membrane organization, apoptosis regulation, Bcl-2 proteins, membrane dynamics, biophysics, and single molecule techniques. She has received numerous fellowships and awards, including the European Research Council (ERC) Starting Grant, the Max-Planck Gesellschaft Postdoctoral scholarship, and the Marie Curie Intra European fellowship, among others, and has been widely published in the field of membrane biochemistry.
Interfaculty Institute for Biochemistry (IFIB), Universität Tübingen, Germany
Michael Rappolt has been appointed as Professor of Lipid Biophysics (School of Food Science and Nutrition) in April 2013. He received his MSc and PhD in physics from the University of Hamburg and achieved his habilitation at the University of Ljubljana in the Faculty of Health Sciences. He was Senior Researcher at the Synchrotron Trieste Outstation (Italy), Institute of Biophysics and Nanosystems Research (Austrian Academy of Sciences), before becoming Assistant Professor at Graz University of Technology. Professor Michael Rappolt is a leading authority on investigating the structure and dynamics of lipid membranes using small-angle X-ray scattering. His recent research activities have concentrated on the study of drug/membrane interactions with potential applications to drug delivery and food. Further research topics concentrate on characterising crystallization processes in food, the investigation of colloid interfaces and the determination of particle structures on the nanoscale. He also seeks to transfer standard measurement techniques applied in food research – such as mechanic (sound and shear) and thermodynamic sample manipulations to synchrotron sites – to understand food on a smaller (nanometre) and faster (microsecond) scale.
University of Leeds, UK