Advances in Biological and Medical Physics

Advances in Biological and Medical Physics

Volume 1

1st Edition - January 1, 1948

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  • Editors: John H. Lawrence, Joseph G. Hamilton
  • eBook ISBN: 9781483281766

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Description

Advances in Biological and Medical Physics, Volume 1, provides an overview of the state of knowledge in biological and medical physics. The book contains 10 chapters and opens with a discussion of methods by which isotopes can be employed in medical and biological problems, and the factors that influence the choice of isotopes that have been and may be used in biological work. This is followed by separate chapters on the applications of nitrogen and carbon isotopes to in vivo studies of the animal organism; the nature and production of artificial radioactivity; the interaction of radioactivity with matter and instruments for detecting ionizing radiation; and the scope of health physics. Subsequent chapters deal with the use of radioactive isotopes to study iron and hemoglobin metabolism and the physiology of the erythrocyte; applications of radioactive phosphorus as a tracer in intermediary metabolism of fat; effects of the atomic bomb irradiation on the Japanese; and nucleic acid metabolism.

Table of Contents


  • Contributors to Volume I

    Foreword

    Heavy and Radioactive Isotopes in Clinical and Experimental Medicine

    I. Introduction

    II. The Medical Significance of Isotopes

    III. Clinical Applications of Isotopes

    IV. Some Applications of Isotopes in Experimental Medicine

    References

    Nitrogen and Carbon Isotopes: Their Application in Vivo to the Study of the Animal Organism

    I. Introduction

    II. Methods

    III. The Metabolism of Nitrogen Compounds

    IV. Carbohydrate and Fat Metabolism

    V. Conclusion

    References

    The Nature and Production of Artificial Radioactivity

    I. The Nature of Radioactivity

    II. Nuclear Relactions

    III. Chemical Factors in Radioisotope Production

    IV. Availability of Radioisotopes

    General References

    Specific References

    Fundamentals of Radioactivity and Its Instrumentation

    I. Interaction of Radiation with Matter

    II. Radioactivity Units and Standards

    III. Basic Instruments for the Detection of Ionizing Radiations

    References

    Health-Physics, Instrumentation, and Radiation Protection

    I. Scope of Health-Physics

    II. Past Experience in Protection

    III. Exposure Standards

    IV. Organization and Functions of a Typical Health-Physics Group

    V. Instruments

    VI. Some Elementary Formula and Calculation Methods

    References

    The Use of Radioactive Isotopes in the Study of Iron and Hemoglobin Metabolism and the Physiology of the Erythrocyte

    I. Introduction

    II. Absorption of Iron

    III. Distribution and Transport of Iron

    IV. Excretion of Iron

    V. Miscellaneous Experimental Procedures Using Tagged Iron

    VI. Effect of Various Conditions on Iron Uptake

    VII, Iron Metabolism in Pathologic States

    VIII. Red Cells Tagged with Radio Iron

    References

    Radioactive Phosphorus: Its Application to the Study of Phospholipid Metabolism

    I. Introduction

    IL Some General Considerations on the Use of Radioactive Phosphorus as a Labeling Agent in the Animal Body

    III. The Amounts of Administered Incorporated into Phospholipids by Tissues of the Animal Body

    IV. How P32 Qan Be Used to Measure the Rate of Turnover of Phospholipid in the Animal Body

    V. Problems in Phospholipid Metabolism to Which P^^ Has Been Successfully Applied

    VI. Summary

    References

    Iodine Metabolism

    I. Introduction

    II. The Entry and Distribution of Iodine in the Body

    III. The Fate of Iodine in the Thyroid Gland

    IV. The Mechanism of the Excretion of Iodized Compounds From the Thyroid

    V. The Fate of the Iodized Compounds Excreted by the Thyroid

    VI. Influence of Various Factors on Iodine Metabolism

    VII. Conclusion

    References

    The Effects of the Atomic Bomb Irradiation on the Japanese

    I. Introduction

    II. Nature of the Physical Agents

    III. Types of Injury (General)

    IV. ClinicalandPathologicalEffectsof Whole Body Irradiation in Animals

    V. Clinical Manifestations

    VI. Pathological Findings

    VII. Summary

    Nucleic Acid Metabolism

    I. Introduction

    II. Structure of the Nucleic Acids

    III. Nucleic Acid Ck)ntent of Tissues

    IV. Nuclear and Cytoplasmic Nucleic Acids

    V. Biological Synthesis of Purine Compounds

    VI. Application of Isotopic Indicators in the Study of the Turnover of Nucleic Acids

    VII. P32 Content of Residual Phosphorus

    VIII. Incorporation of P32 into Desoxyribosenucleic Acid

    IX. Incorporation of P32 into Ribosenucleic Acid

    X. Desoxyribosenucleic Acid Turnover and Cell Division

    XI. Application of Labeled Desoxyribosenucleic Acid in the Determination of the Life-Cycle of the Red Corpuscles of the Hen

    XII. Intravenous Transfer of P32 from Chromatin to Hepatic Tissue

    XIII. Studies of Virus Reproduction with P32 as a Tracer

    XIV. Enzymatic Studies with Labeled Desoxyribosenucleic Acid as a Substrate

    XV. Effect of Roentgen Rays on the Formation of Labeled Desoxyribosenucleic Acid

    XVI. Effect of Beta Rays Endtted by l^dioactive Colloids Taken Up by the Liver on the Formation of Labeled Desoxyribosenucleic Acid

    References

    Author Index

    Subject Index

Product details

  • No. of pages: 496
  • Language: English
  • Copyright: © Academic Press 1948
  • Published: January 1, 1948
  • Imprint: Academic Press
  • eBook ISBN: 9781483281766

About the Editors

John H. Lawrence

Joseph G. Hamilton

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