Advances in Biological and Medical Physics

Advances in Biological and Medical Physics

Volume 17

1st Edition - January 1, 1980

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  • Editors: John H. Lawrence, John W. Gofman, Thomas L. Hayes
  • eBook ISBN: 9781483215013

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Advances in Biological and Medical Physics, Volume 17 covers articles on the advances in biological and medical physics. The book presents articles on energy transfer dynamics; the molecular mechanism of DNA repair after ionizing radiation; and mechanisms of prereplication repair of DNA breaks in gamma-irradiated E. coli cells. The text then describes articles about damages to DNA that result in neoplastic transformation; the nature of radiation and chemically-induced lesions and the role of cellular mechanisms in cell survival and mutagenesis; as well as the nature of the target in the biological action of ionizing radiation. The gated detection and analysis of nanosecond pulse excitation and the time-profile multicomponent analysis using nonintrusive mass spectrometry are also considered. The book further tackles the technique of acoustic microscopy in biophysics and the use of electron spin echo spectroscopy in the study of biological structure and function. The text also describes radiation as an oncogen and as a cocarcinogen at the cellular level and speculates on some possible molecular and cellular mechanisms of radiocarcinogenesis. Biological and medical physicists, biologists, and chemists will find the book invaluable.

Table of Contents

  • Contributors to Volume 17

    Energy Transfer Dynamics

    I. Introduction

    II. Preliminaries

    III. General Energy Relations for Nonlinear Elements

    IV. The "Mathematical Genes" for Energy Transfer

    V. Jahn-Teller Coupling

    VI. The Superconductive State as Parametric Resonance

    VII. Vibrational Quanta

    VIII. Interaction between Vibration and Rotation (Coriolis Effect)

    IX. Nonlinear Polarization

    X. A Laser as a Noise-Driven Van der Pol Oscillator

    XI. Stimulated Raman Scattering

    XII. Cancer Induction

    XIII. Off-Diagonal Long-Range Order (ODLRO)

    XIV. Conclusion




    Molecular Mechanism of DNA Repair after Ionizing Radiation



    Mechanisms of Prereplication Repair of DNA Breaks in λ-Irradiated E. coli Cells



    Damages to DNA that Result in Neoplastic Transformation

    I. Introduction

    II. Photoreactivation

    III. Excision Repair as an Aid in Identifying Damage

    IV. Conclusions


    Nature of Radiation and Chemically Induced Lesions and Role of Cellular Mechanisms in Cell Survival and Mutagenesis. I. Membrane and Cellular Repair

    I. Introduction

    II. Modified Cellular Membrane and Damaged DNA

    III. Damaged Membrane and Damaged DNA

    IV. Membrane and UV Damage


    Nature of Radiation and Chemically Induced Lesions and Role of Cellular Mechanism in Cell Survival and Mutagenesis. II.

    I. Introduction

    II. Materials and Methods

    III. Survival Following Exposure to Psoralen plus 360 nm Light

    IV. Intracellular DNA Degradation Following λ-Irradiation

    V. Spontaneous and Induced Mutagenesis

    VI. Discussion


    The Nature of the Target in the Biological Action of Ionizing Radiations

    I. Introduction

    II. Target Theory: Size and Number of Critical Targets

    III. Modifying Factors: A Tool in the Identification of Critical Targets

    IV. End Effects of Radiation Action Not Requiring Mitotic Activity

    V. Concluding Remarks


    Note Added in Proof

    Fluorescence and Photosynthesis: Gated Detection and Analysis of Nanosecond Pulse Excitation

    I. Introduction

    II. Experimental

    III. Time Course of Fluorescence Change

    IV. The Effects of Multiple Excitations on the Fluorescence Change

    V. Conclusions



    Time-Profile, Multicomponent Analysis Using Nonintrusive Mass Spectrometry

    I. Introduction

    II. Mass Spectrometer-Computer Tools for Nonintrusive Multicomponent, Time-Profile Analyses

    III. Nonintrusive Profiles: Chemical Stimuli and Chemical Responses

    IV. Concluding Remarks


    Acoustic Microscopy in Biophysics

    I. Introduction

    II. The Properties of Acoustic Waves

    III. A Description of the Instrument

    IV. The Properties of the Acoustic Beam through Spatial Frequency Analysis

    V. The Acoustic Images


    Electron Spin Echo Spectroscopy and the Study of Biological Structure and Function

    I. Introduction

    II. Definition of Electron Spin Echo

    III. Why Electron Spin Echo?

    IV. Electron Spin Echo Physics

    V. Instrumentation

    VI. Typical Applications of Electron Spin Echo

    VII. Additional Aspects of Electron Spin Echo in Biological Systems

    VIII. Concluding Remarks


    Radiation and Cell Transformation in Vitro

    I. Introduction

    II. Radiation as an Oncogen

    III. Radiation as an Cocarcinogen

    IV. Possible Mechanisms of Radiation Oncogenesis and Cocarcinogenesis in Cultured Mammalian Cells

    V. Summary



    Contents of Previous Volumes

Product details

  • No. of pages: 486
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 1, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9781483215013

About the Editors

John H. Lawrence

John W. Gofman

Thomas L. Hayes

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