Advances in Biological and Medical Physics

Advances in Biological and Medical Physics

Volume 13

1st Edition - January 1, 1970

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  • Editors: John H. Lawrence, John W. Gofman
  • eBook ISBN: 9781483214986

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Description

Advances in Biological and Medical Physics, Volume 13 covers articles on the advances in biological and medical physics. The book presents papers on the solid-state physics of electron and ion transport in biology; on microelectrophoretic studies on the surface chemistry of erythrocytes; and on a specific common chromosomal pathway for the origin of human malignancy, including an evaluation of long-term human hazards of potential environmental carcinogens. The text then discusses the instantaneous radiation levels at different altitudes and latitudes; the accumulated radiation exposures to crew members and passengers; and the resulting radiation burden to the entire population. The theory and practical application of the selective destruction of cell organelles by laser beam, as well as some aspects of radiation effects on cell membranes are also considered. The book further tackles the effects of radiation on artificial lipid membranes; the role of bacterial membranes in radiosensitization; and the effects of ionizing radiation on lysosomes and other intracellular membranes. The text also describes the high oxygen effect for the release of enzymes from isolated mammalian lysosomes after treatment with ionizing radiation; as well as the effects of ultraviolet and visible light on nerve fibers and changes in optical properties during nervous activity. The effects of ultraviolet radiation on isolated nerve fibers are also looked into. Biological and medical physicists and students taking these courses will find the book invaluable.

Table of Contents


  • Contributors to Volume 13

    The Solid-State Physics of Electron and Ion Transport in Biology

    I. Introduction

    II. Kinetic Theory of Electron Transport Reactions by Solid-State Mechanisms

    III. Detailed Mechanisms of Charge Conduction in Subcellular Particles

    IV. Does Solid-State Biological Electron Conduction Occur through Protein, Lipid, or Water?

    V. Cytochrome OxidaseラIts Solid-State Physical Behavior in the Functional and in the Dry State

    VI. The Solid-State Picture of Cell Water and Electrolytes

    VII. The Structure of Ionic Conduction Bands in Cell Water

    VIII. Graphical Criteria of Solid-State Kinetics in Biology

    Appendix. The Accuracy of the λ-Approximation

    References

    Microelectrophoretic Studies on the Surface Chemistry of Erythrocytes

    I. Introduction

    II. The Microelectrophoretic Method

    III. Studies on the Surface Chemistry of Erythrocytes at Physiological Ionic Strength

    References

    A Specific Common Chromosomal Pathway for the Origin of Human Malignancy. II. Evaluation of Long-Term Human Hazards of Potential Environmental Carcinogens

    I. Experimental

    II. Experimental Results—Human Cell Lines

    III. Experimental Results—Freshly Obtained Human Cancers

    IV. Possible Exceptions to the E16 Hypothesis

    V. Corroborative Evidence from the Literature

    VI. Conclusions Based upon 17 Human Cell Lines plus 11 Fresh Human Cancers

    VII. Viruses, Ionizing Radiations, Chemical Carcinogens

    References

    Radiation Exposure on High-Altitude Passenger Flights

    I. Introduction

    II. Radiation Environment at High Altitudes

    III. Radiation Environment in the Biosphere

    IV. Radiobiological Significance of High-Altitude Exposure

    V. Special Problems

    References

    Radiation Effects on Biological Membranes

    Symposium at Third International Congress of Biophysics Cambridge, Massachusetts, August 29-September 3, 1969 (Sponsored by the International Commission of Radiation Biophysics)

    Selective Destruction of Cell Organelles by Laser Beam (Theory and Practical Application)

    I. Introduction

    II. Materials and Methods

    III. Evaluation of the Various Parameters of Laser Microirradiation in the Selective Destruction of Cellular Organelles

    IV. Selective Destruction of Mitochondria

    V. Use of an Ultraviolet Laser Microbeam

    References

    Some Aspects of Radiation Effects on Cell Membranes

    I. Introduction

    II. Permeability Changes in Erythrocytes

    III. Oxidation of Membrane Thiols

    IV. Disruption of Disulfide Bonds

    V. Lipoprotein Disorganization

    VI. Hemolysis and Membrane Antioxidants

    VII. Effect of Radiosensitizing Agents

    VIII. Thymus Lymphocytes

    IX. Yeast Cells

    X. Bacterial Cells

    XI. Conclusions

    References

    Effects of Radiation on Artificial Lipid Membranes

    I. Introduction

    II. Experimental

    III. Results

    IV. Discussion

    References

    Role of Bacterial Membranes in Radiosensitization

    I. Introduction

    II. Mechanism of Radiosensitization

    III. Conclusions

    References

    Effects of Ionizing Radiation on Lysosomes and Other Intracellular Membranes

    I. Introduction

    II. Survey of Intracellular Membranes

    III. Effects of Radiation on Intracellular Membranes

    IV. Mechanisms of Membrane Damage

    V. Summary

    Addendum

    References

    High Oxygen Effect for the Release of Enzymes from Isolated Mammalian Lysosomes after Treatment with Ionizing Radiation

    I. Introduction

    II. Experimental Techniques

    III. Results and Discussion

    IV. Conclusion

    References

    Effects of Ultraviolet and Visible Light on Nerve Fibers and Changes in Optical Properties During Nervous Activity

    I. Introduction

    II. Brief Historical Accounts of Effects of Light on Nerve Membrane

    III. Macromolecular Approach to Process of Nerve Excitation

    IV. Fluorescent Studies of Nerve

    V. Summary

    Addendum

    References

    Ultraviolet Radiation Effects on Isolated Nerve Fibers

    I. Introduction

    II. Effects of Ultraviolet Radiation on Nerve Excitability

    III. Studies on the Localization of the Sites of Action of Ultraviolet Radiations

    IV. Ultraviolet Inactivation of Nerve Na+–K+-Stimulated ATPase

    V. Summary and Conclusions

    References

    Electrophysiologic Responses of Sciatic Nerves Exposed to 200-kV X-Rays and 47.5-MeV Protons

    I. Introduction

    II. Methods

    III. Results

    IV. Discussion

    V. Summary

    References

    Author Index

    Subject Index

    Contents of Previous Volumes




Product details

  • No. of pages: 406
  • Language: English
  • Copyright: © Academic Press 1970
  • Published: January 1, 1970
  • Imprint: Academic Press
  • eBook ISBN: 9781483214986

About the Editors

John H. Lawrence

John W. Gofman

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