Advances in Biological and Medical Physics - 1st Edition - ISBN: 9780120052134, 9781483214986

Advances in Biological and Medical Physics

1st Edition

Volume 13

Editors: John H. Lawrence John W. Gofman
eBook ISBN: 9781483214986
Imprint: Academic Press
Published Date: 1st January 1970
Page Count: 406
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Advances in Biological and Medical Physics, Volume 13 covers articles on the advances in biological and medical physics. The book presents papers on the solid-state physics of electron and ion transport in biology; on microelectrophoretic studies on the surface chemistry of erythrocytes; and on a specific common chromosomal pathway for the origin of human malignancy, including an evaluation of long-term human hazards of potential environmental carcinogens. The text then discusses the instantaneous radiation levels at different altitudes and latitudes; the accumulated radiation exposures to crew members and passengers; and the resulting radiation burden to the entire population.
The theory and practical application of the selective destruction of cell organelles by laser beam, as well as some aspects of radiation effects on cell membranes are also considered. The book further tackles the effects of radiation on artificial lipid membranes; the role of bacterial membranes in radiosensitization; and the effects of ionizing radiation on lysosomes and other intracellular membranes. The text also describes the high oxygen effect for the release of enzymes from isolated mammalian lysosomes after treatment with ionizing radiation; as well as the effects of ultraviolet and visible light on nerve fibers and changes in optical properties during nervous activity. The effects of ultraviolet radiation on isolated nerve fibers are also looked into. Biological and medical physicists and students taking these courses will find the book invaluable.

Table of Contents

Contributors to Volume 13

The Solid-State Physics of Electron and Ion Transport in Biology

I. Introduction

II. Kinetic Theory of Electron Transport Reactions by Solid-State Mechanisms

III. Detailed Mechanisms of Charge Conduction in Subcellular Particles

IV. Does Solid-State Biological Electron Conduction Occur through Protein, Lipid, or Water?

V. Cytochrome OxidaseラIts Solid-State Physical Behavior in the Functional and in the Dry State

VI. The Solid-State Picture of Cell Water and Electrolytes

VII. The Structure of Ionic Conduction Bands in Cell Water

VIII. Graphical Criteria of Solid-State Kinetics in Biology

Appendix. The Accuracy of the λ-Approximation


Microelectrophoretic Studies on the Surface Chemistry of Erythrocytes

I. Introduction

II. The Microelectrophoretic Method

III. Studies on the Surface Chemistry of Erythrocytes at Physiological Ionic Strength


A Specific Common Chromosomal Pathway for the Origin of Human Malignancy. II. Evaluation of Long-Term Human Hazards of Potential Environmental Carcinogens

I. Experimental

II. Experimental Results—Human Cell Lines

III. Experimental Results—Freshly Obtained Human Cancers

IV. Possible Exceptions to the E16 Hypothesis

V. Corroborative Evidence from the Literature

VI. Conclusions Based upon 17 Human Cell Lines plus 11 Fresh Human Cancers

VII. Viruses, Ionizing Radiations, Chemical Carcinogens


Radiation Exposure on High-Altitude Passenger Flights

I. Introduction

II. Radiation Environment at High Altitudes

III. Radiation Environment in the Biosphere

IV. Radiobiological Significance of High-Altitude Exposure

V. Special Problems


Radiation Effects on Biological Membranes

Symposium at Third International Congress of Biophysics Cambridge, Massachusetts, August 29-September 3, 1969 (Sponsored by the International Commission of Radiation Biophysics)

Selective Destruction of Cell Organelles by Laser Beam (Theory and Practical Application)

I. Introduction

II. Materials and Methods

III. Evaluation of the Various Parameters of Laser Microirradiation in the Selective Destruction of Cellular Organelles

IV. Selective Destruction of Mitochondria

V. Use of an Ultraviolet Laser Microbeam


Some Aspects of Radiation Effects on Cell Membranes

I. Introduction

II. Permeability Changes in Erythrocytes

III. Oxidation of Membrane Thiols

IV. Disruption of Disulfide Bonds

V. Lipoprotein Disorganization

VI. Hemolysis and Membrane Antioxidants

VII. Effect of Radiosensitizing Agents

VIII. Thymus Lymphocytes

IX. Yeast Cells

X. Bacterial Cells

XI. Conclusions


Effects of Radiation on Artificial Lipid Membranes

I. Introduction

II. Experimental

III. Results

IV. Discussion


Role of Bacterial Membranes in Radiosensitization

I. Introduction

II. Mechanism of Radiosensitization

III. Conclusions


Effects of Ionizing Radiation on Lysosomes and Other Intracellular Membranes

I. Introduction

II. Survey of Intracellular Membranes

III. Effects of Radiation on Intracellular Membranes

IV. Mechanisms of Membrane Damage

V. Summary



High Oxygen Effect for the Release of Enzymes from Isolated Mammalian Lysosomes after Treatment with Ionizing Radiation

I. Introduction

II. Experimental Techniques

III. Results and Discussion

IV. Conclusion


Effects of Ultraviolet and Visible Light on Nerve Fibers and Changes in Optical Properties During Nervous Activity

I. Introduction

II. Brief Historical Accounts of Effects of Light on Nerve Membrane

III. Macromolecular Approach to Process of Nerve Excitation

IV. Fluorescent Studies of Nerve

V. Summary



Ultraviolet Radiation Effects on Isolated Nerve Fibers

I. Introduction

II. Effects of Ultraviolet Radiation on Nerve Excitability

III. Studies on the Localization of the Sites of Action of Ultraviolet Radiations

IV. Ultraviolet Inactivation of Nerve Na+–K+-Stimulated ATPase

V. Summary and Conclusions


Electrophysiologic Responses of Sciatic Nerves Exposed to 200-kV X-Rays and 47.5-MeV Protons

I. Introduction

II. Methods

III. Results

IV. Discussion

V. Summary


Author Index

Subject Index

Contents of Previous Volumes


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© Academic Press 1970
Academic Press
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About the Editor

John H. Lawrence

John W. Gofman

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