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Advances in Bacterial Pathogen Biology
1st Edition, Volume 65 - November 11, 2014
Editor: Robert K. Poole
Language: English
Hardback ISBN:9780128001424
9 7 8 - 0 - 1 2 - 8 0 0 1 4 2 - 4
eBook ISBN:9780128003053
9 7 8 - 0 - 1 2 - 8 0 0 3 0 5 - 3
This volume is an up-to-date overview of the physiology of selected pathogenic bacteria. Each chapter is written by experts in the field of that organism.The focus is on bi…Read more
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This volume is an up-to-date overview of the physiology of selected pathogenic bacteria. Each chapter is written by experts in the field of that organism.The focus is on biochemistry and physiology but topics of clinical relevance are included.
Contributions from leading authorities
Informs and updates on all the latest developments in the field
Microbiologists, biochemists, biotechnologists, and those interested in physiology, microbial biochemistry and its applications.
Chapter One: Energetics of Pathogenic Bacteria and Opportunities for Drug Development
Abstract
1 Introduction
2 Bacterial Energetics as a Target Space for Drug Development
3 Conclusions and Future Perspectives
Acknowledgements
Chapter Two: The Impact of Horizontal Gene Transfer on the Biology of Clostridium difficile
Abstract
1 Introduction to Clostridium difficile and CDI
2 Introns
3 IStrons
4 Mobilisable Transposons
5 Conjugative Transposons
6 Other Integrative MGEs in C. difficile
7 The skinCd Element
8 Bacteriophages
9 Transfer of the PaLoc
10 Conclusions
Chapter Three: Metal Ion Homeostasis in Listeria monocytogenes and Importance in Host–Pathogen Interactions
Abstract
1 Introduction
2 Overview of Listeria monocytogenes Disease Progression
3 Control of Metal Levels in Bacteria
4 L. monocytogenes and Zinc
5 L. monocytogenes and Copper
6 Concluding Remarks
Chapter Four: The Role of Macrophages in the Innate Immune Response to Streptococcus pneumoniae and Staphylococcus aureus: Mechanisms and Contrasts
Abstract
1 Introduction
2 S. pneumoniae Virulence Factors Impede Phagocytosis and Its Consequences
3 S. aureus Virulence Factors Subvert Multiple Innate Immune Responses Including Intracellular Killing
4 Origins of Macrophages
5 The Spectrum of Macrophage Activation
6 Epigenetic Regulation of Macrophage Function
7 Mechanisms of Macrophage Phagocytosis
8 Phagocytosis of S. pneumoniae and S. aureus
9 Intracellular Localisation of Bacteria
10 Microbial Killing by Macrophages
11 Apoptosis-Associated Killing Complements Clearance of S. pneumoniae
12 Macrophage Killing of S. aureus
13 Macrophage Orchestration of the Inflammatory Response
14 Pattern Recognition Receptors in the Recognition of S. pneumoniae and S. aureus
15 Conclusion
Conflict of Interest
Chapter Five: Aeromonas Flagella and Colonisation Mechanisms
Abstract
1 Introduction
2 Flagella
3 Lipopolysaccharide and Capsules
4 Pili
5 Outer-Membrane Proteins and S-Layer
6 Aeromonad Colonisation and Host Response
7 Conclusions and Outlook
Chapter Six: Physiological Adaptations of Key Oral Bacteria
Abstract
1 Introduction
2 Key Oral Environmental Niches
3 The Major Infections of the Oral Cavity
4 Bacterial Adaptations in the Oral Cavity
5 Surface Adhesins as Colonisation Factors of Oral Bacteria
6 Stress Responses of Import in Colonisation and Infection by Oral Bacteria
7 Summary and Future Perspectives
Acknowledgements
Chapter Seven: Virulence Factors of Uropathogenic E. coli and Their Interaction with the Host
Abstract
1 Introduction
2 Pathogenesis of Urinary Tract Infection
3 Adhesins
4 Toxins
5 Iron-Acquisition Systems
6 Immune Evasion Mechanisms
7 Conclusion
No. of pages: 448
Language: English
Edition: 1
Volume: 65
Published: November 11, 2014
Imprint: Academic Press
Hardback ISBN: 9780128001424
eBook ISBN: 9780128003053
RP
Robert K. Poole
Professor Robert Poole is West Riding Professor of Microbiology at the University of Sheffield. He has >35 years’ experience of bacterial physiology and bioenergetics, in particular O2-, CO- and NO-reactive proteins, and has published >300 papers (h=48, 2013). He was Chairman of the Plant and Microbial Sciences Committee of the UK Biotechnology and Biological Sciences Research Council and has held numerous grants from BBSRC, the Wellcome and Leverhulme Trusts and the EC. He coordinates an international SysMO systems biology consortium. He published pioneering studies of bacterial oxidases and globins and discovered the bacterial flavohaemoglobin gene (hmp) and its function in NO detoxification He recently published the first systems analyses of responses of bacteria to novel carbon monoxide-releasing molecules (CORMs) and is a world leader in NO, CO and CORM research.
Affiliations and expertise
West Riding Professor of Microbiology, Department of Molecular Biology and Biotechnology, University of Sheffield, UK
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