Advanced Wound Repair Therapies

Advanced Wound Repair Therapies

1st Edition - June 21, 2011

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  • Editor: David Farrar
  • eBook ISBN: 9780857093301
  • Hardcover ISBN: 9781845697006

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Description

Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds.Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices.With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject.

Key Features

  • Provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds
  • Chapters include the role of micro-organisms and biofilms in dysfunctional wound healing, tissue-biomaterial interaction and electrical stimulation for wound healing
  • Covers biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair

Readership

Researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject.

Table of Contents

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    Introduction

    Part I: Introduction to chronic wounds

    Chapter 1: Dysfunctional wound healing in chronic wounds

    Abstract:

    1.1 Normal skin wound healing

    1.2 Ageing skin and the onset of chronic, dysfunctional wound healing

    1.3 Dysfunctional healing of chronic skin wounds

    1.4 Conclusions

    1.5 Acknowledgements

    Chapter 2: The role of micro-organisms and biofilms in dysfunctional wound healing

    Abstract:

    2.1 Introduction

    2.2 Microbiology and biofilms: not mutually exclusive

    2.3 Biofilms and the interactive cooperative community

    2.4 Biofilms in chronic wounds

    2.5 Biofilms as therapeutic or restorative microbiology/modeling

    2.6 Conclusion

    Chapter 3: Scarring and scarless wound healing

    Abstract:

    3.1 Introduction

    3.2 Wound healing process

    3.3 Fibroproliferative scarring

    3.4 Scarless fetal wound healing

    3.5 Adult versus fetal wound healing

    3.6 Treatment options for scars

    3.7 Future trends

    3.8 Conclusions

    Chapter 4: The discovery and development of new therapeutic treatments for the improvement of scarring

    Abstract:

    4.1 Introduction

    4.2 Scar-free and scar-forming healing

    4.3 In vitro and in vivo models to investigate the mechanisms of scarring and evaluate potential treatments

    4.4 Translation from pre-clinical studies to clinical efficacy

    4.5 Understanding the mechanisms of action of prophylactic scar improvement therapies

    4.6 Conclusions

    Chapter 5: Monitoring chronic wounds and determining treatment

    Abstract:

    5.1 Introduction

    5.2 Wound size measurements

    5.3 Wound colour measurements

    5.4 Background material

    Part II: Biomaterial therapies for chronic wounds

    Chapter 6: Functional requirements of wound repair biomaterials

    Abstract:

    6.1 Introduction

    6.2 Wound pain and dressing materials

    6.3 Exudate management

    6.4 Prevention and control of infection

    6.5 Odour management

    6.6 Future trends

    6.7 Sources of further information and advice

    Chapter 7: Tissue-biomaterial interactions

    Abstract:

    7.1 Introduction: definitions

    7.2 Overview of tissue-biomaterial interactions

    7.3 Interactions at the biomaterial surface

    7.4 Tissue response to biomaterial

    7.5 Conclusion

    Chapter 8: Polymeric materials for chronic wound and burn dressings

    Abstract:

    8.1 Introduction

    8.2 Advanced moisture-retentive wound dressings

    8.3 Polymeric materials in moist wound healing dressings

    8.4 Infection control by polymeric wound dressings

    8.5 Conclusion

    8.6 Future trends

    8.7 Acknowledgements

    Chapter 9: Dry wound healing concept using spray-on dressings for chronic wounds

    Abstract:

    9.1 Introduction

    9.2 The key properties of an ideal wound dressing

    9.3 Using protein-based spray-on dressings in practice

    9.4 Case studies

    9.5 Conclusions

    Chapter 10: Assessing the effectiveness of antimicrobial wound dressings in vitro

    Abstract:

    10.1 Introduction

    10.2 Log reduction testing

    10.3 Zone of inhibition (ZOI)

    10.4 Bacterial barrier testing

    10.5 Other considerations

    10.6 Sources of further information and advice

    Chapter 11: Adhesives and interfacial phenomena in wound healing

    Abstract:

    11.1 Principles of adhesion, adhesivity and interfacial behaviour

    11.2 Bioadhesion: principles of adhesion applied to wound healing

    11.3 Adhesives in wound healing: materials overview

    11.4 Surgical adhesives and tissue sealants: structure and properties

    11.5 Conclusions

    Chapter 12: Wound healing studies and interfacial phenomena: use and relevance of the corneal model

    Abstract:

    12.1 Wound dressing biomaterials: interfacial aspects of compatibility and wound response

    12.2 The corneal model in wound healing and biomaterial studies

    12.3 Interfacial phenomena in ocular surface contact lens studies

    12.4 Wound fluid and the tear film collection

    12.5 Biomaterials in mucosal wound healing

    12.6 Conclusions

    Chapter 13: Sulphonated biomaterials as glycosaminoglycan mimics in wound healing

    Abstract:

    13.1 Introduction

    13.2 Polymers and biomimesis

    13.3 Biomimetic models

    13.4 Sulphonated biomaterials in the context of biomimetic principles

    13.5 Sulphonated biomaterials and the chronic wound: possible modes of biomimetic behaviour

    13.6 Conclusions

    Part III: Molecular therapies for chronic wounds

    Chapter 14: Drug delivery dressings

    Abstract:

    14.1 Introduction

    14.2 The role of drug delivery dressings in wound management

    14.3 Topically delivered therapeutic compounds

    14.4 Hydrocolloids

    14.5 Hydrogels

    14.6 Collagen

    14.7 Alginates

    14.8 Honey

    14.9 Future trends

    Chapter 15: Molecular and gene therapies for wound repair

    Abstract:

    15.1 Introduction

    15.2 Methods of gene delivery

    15.3 Gene therapy for wound healing

    15.4 Ethical issues

    15.5 Future trends

    Chapter 16: Antimicrobial dressings

    Abstract:

    16.1 Introduction

    16.2 Types of currently available dressings/formulations

    16.3 Types of ‘antimicrobials’

    16.4 Future trends

    Chapter 17: Avotermin: emerging evidence of efficacy for the improvement of scarring

    Abstract:

    17.1 There is a medical need for therapies that reduce scarring following surgery

    17.2 Current treatments for scar management are unsatisfactory

    17.3 New biological approaches are in development for the prophylactic improvement of scarring

    17.4 Conclusions and future trends

    Part IV: Biologically derived and cell-based therapies for chronic wounds

    Chapter 18: Engineered tissues for wound repair

    Abstract:

    18.1 Introduction

    18.2 The wound microenvironment in wound repair

    18.3 Traditional approaches to wound repair

    18.4 Development of cellular therapies

    18.5 Development of acellular therapies

    18.6 Conclusion

    18.7 Acknowledgement

    Chapter 19: Commercialization of engineered tissue products

    Abstract:

    19.1 Introduction

    19.2 Engineered templates and scaffolds

    19.3 Processed tissues

    19.4 Cell-based products

    19.5 Lessons from the first generation

    19.6 The second generation of advanced therapies

    19.7 Delivering value in advanced therapies

    19.8 Advanced therapies in the marketplace

    19.9 Conclusion

    Chapter 20: Biologically derived scaffolds

    Abstract:

    20.1 Introduction

    20.2 Polyhydroxyalkanoate (PHA)-derived scaffolds

    20.3 Silk-derived scaffolds

    20.4 Collagen-derived scaffolds

    20.5 Elastin-derived scaffolds

    20.6 Resilin-derived scaffolds

    20.7 Keratin-derived scaffolds

    20.8 Polysaccharide-derived scaffolds

    20.9 Conclusions and future trends

    Chapter 21: Stem cell therapies for wound repair

    Abstract:

    21.1 Introduction

    21.2 Frequently utilized sources of adult stem cells

    21.3 Clinical applications of stem cells to wound healing

    21.4 Conclusions

    21.5 Acknowledgement

    21.7 Appendix: list of abbreviations

    Part V: Physical stimulation therapies for chronic wounds

    Chapter 22: Electrical stimulation for wound healing

    Abstract:

    22.1 Introduction

    22.2 Current of injury

    22.3 Physiological effects of electrical stimulation

    22.4 Antibacterial effects of electrical stimulation

    22.5 The effect of high voltage pulsed current (HVPC) on wound healing

    22.6 The effect of low intensity direct currents (LIDC) on wound healing

    22.7 Other types of electrical stimulation applied to wounds

    22.8 Discussion

    22.9 Conclusion

    Chapter 23: Negative pressure wound therapy

    Abstract:

    23.1 Introduction

    23.2 History of negative pressure wound therapy

    23.3 The science of negative pressure

    23.4 The pathophysiologic mechanisms of action of negative pressure

    23.5 The search for the perfect negative pressure technology

    23.6 Conclusions

    23.7 Acknowledgement

    Chapter 24: Debridement methods of non-viable tissue in wounds

    Abstract:

    24.1 Introduction

    24.2 Background

    24.3 Complications of non-viable tissue in wounds and the need for debridement

    24.4 Presence of biofilm

    24.5 Organisation of debridement

    24.6 Timing and types of debridement

    24.7 Scoring the effectiveness of debridement

    24.8 Debridement in the diabetic foot

    24.9 Conclusions

    Index

Product details

  • No. of pages: 672
  • Language: English
  • Copyright: © Woodhead Publishing 2011
  • Published: June 21, 2011
  • Imprint: Woodhead Publishing
  • eBook ISBN: 9780857093301
  • Hardcover ISBN: 9781845697006

About the Editor

David Farrar

David Farrar is Science Manager for Biomaterials at the Smith and Nephew Research Centre, York, UK

Affiliations and Expertise

Smith and Nephew, UK

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