Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics

Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics

1st Edition - October 1, 2022

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  • Editors: Prakash Saudagar, Timir Tripathi
  • Paperback ISBN: 9780323991278

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Description

Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics presents the latest emerging technologies in spectroscopy and advances in established spectroscopic methods. The book presents a guide to research methods in biomolecular spectroscopy, providing comprehensive coverage of developments in the spectroscopic techniques used to study protein structure and dynamics. Seventeen chapters from leading researchers cover key aspects of spectroscopic methods, with each chapter covering structure, folding, and dynamics. This title will help researchers keep up-to-date on the latest novel methods and advances in established methods.

Key Features

  • Presents current, emerging, and evolving advances and applications of spectroscopic techniques in the study of biomolecules, including proteins and nucleic acids
  • Discusses contemporary spectroscopic techniques used to study biomolecular structure, interaction, and dynamics

Readership

Researchers and advanced students in biophysics, structural biology, computational biology, biochemistry, and molecular biology

Table of Contents

  • 1. Fundamentals of spectroscopy for biomolecular structure and dynamics
    2. Fluorescence-based techniques to assess biomolecular structure and dynamics
    3. Structural analysis of biomacromolecules using circular dichroism spectroscopy
    4. Nuclear magnetic resonance spectroscopy for protein structure, folding, and dynamics
    5. Advanced NMR spectroscopy methods to study protein structure and dynamics
    6. Applications of infrared spectroscopy to study proteins
    7. Raman spectroscopy to study biomolecules, their structures, and dynamics
    8. Spectroscopic investigation of biomolecular dynamics using light scattering methods
    9. Protein footprinting by mass spectrometry: H/D exchange, specific amino acid labeling, and fast photochemical oxidation of proteins
    10. Small angle scattering techniques for biomolecular structure and dynamics
    11. Advances in X-ray crystallography methods to study structural dynamics of macromolecules
    12. Spectroscopic methods to study protein folding kinetics: methodology, data analysis, and interpretation
    13. Spectroscopic methods to study the thermodynamics of biomolecular interactions
    14. Spectroscopic methods to detect and analyze protein oligomerization, aggregation, and fibrillation
    15. Multimodal spectroscopic methods for the analysis of carbohydrates
    16. Integration of spectroscopic and computational data to analyze protein structure, function, folding, and dynamics
    17. Advance data handling tools for easy, fast, and accurate interpretation of spectroscopic data

Product details

  • No. of pages: 450
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: October 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323991278

About the Editors

Prakash Saudagar

Dr. Prakash Saudagar is an active researcher and a sterling classroom teacher, currently working as an Assistant Professor at the Department of Biochemistry, National Institute of Technology Warangal, India. He obtained his Ph.D. degree from the Indian Institute of Technology, Guwahati, India, in 2013. His research has immensely contributed to exploring potential drug target proteins and inhibitors. His research interests include molecular and biochemical parasitology, infectious disease, and protein biochemistry. He has a strong command over computational techniques and in-vitro techniques used to study proteins. He has published more than 40 research articles in reputed journals like the International Journal of Biological Molecules, FEBS, FEBS OpenBio, PLOS one, Scientific Reports, Biological Chemistry, Parasitology International, Molecular Simulation, etc., and book chapters in Elsevier and Springer to his name. He has been PI/Co-PI in research grants from SERB and DST. He has been awarded the B.S. Narasinga Rao award SBC, India (2011), Best presentation award, ICIDN, Nepal (2015), Young Faculty Award, VIF India (2016), and Young Scientist Award, Telangana Academy of Science (2018). He is an associate fellow of the Telangana Academy of Science (2018) and a life member of the Indian Science Congress and Society of Biological Chemists. He has guided several Ph.D. and M.Tech. students, postdoctoral fellows, project fellows, and trainees. He has many interdisciplinary collaborating partners in prestigious institutions in India and abroad.

Affiliations and Expertise

Assistant Professor at the Department of Biochemistry, National Institute of Technology Warangal, India

Timir Tripathi

Timir Tripathi is the Regional Director of Indira Gandhi National Open University (IGNOU), Regional Centre Kohima, Nagaland, India. Earlier, he served as Senior Assistant Professor and Principal Investigator at the Department of Biochemistry, North-Eastern Hill University, Shillong, India. He holds a Ph.D. from the Central Drug Research Institute, Lucknow, India. He was a visiting faculty at ICGEB, New Delhi, India (2011), and Khon Kaen University, Thailand (2015). He is known for his research in the fields of protein biophysics, biochemistry, structural biology, and drug discovery. He has over 16 years of experience in teaching and research on protein structure, function, and dynamics at the post-graduate and doctoral levels. He has developed and improved methods to investigate and analyze proteins. His research areas include protein interaction dynamics and understanding the roles of non-catalytic domains in regulating the catalytic activity of proteins. The common theme in his research is an interest in understanding biological phenomena involving proteins at the molecular, structural, and mechanistic levels. He has handled several research grants as a principal investigator from various national and international funding agencies, including DST-Russian Foundation for Basic Research, UGC-Israel Science Foundation, DBT, SERB, DHR, and ICMR. He has received several awards, including Prof. B.K. Bachhawat Memorial Young Scientist Lecture Award (2020) by the National Academy of Sciences, India, ISCB-Young Scientist Award (2019), ICMR-Shakuntala Amir Chand Prize (2018), BRSI-Malviya Memorial Award (2017), DST Fasttrack Young Scientist Award (2012), DBT Overseas Associateship Award (2012), Dr. D.M. Bose Award (2008), etc. He is an elected member of the National Academy of Sciences, India, and the Royal Society of Biology, UK. He has published more than 100 research papers, reviews, commentaries, viewpoints, and editorial articles in international journals, has edited three books, and published several book chapters. He currently serves on the editorial boards of several international journals, including International Journal of Biological Macromolecules, Acta Tropica, Scientific Reports, PLoS One, etc.

Affiliations and Expertise

Regional Director of Indira Gandhi National Open University (IGNOU), Regional Centre Kohima, Nagaland, India

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