Advanced Mass Spectrometry

Applications in Organic and Analytical Chemistry

1st Edition - January 1, 1980
Author: Urs P. Schlunegger
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 1 - 8 8 8 7 - 4

Advanced Mass Spectrometry: Applications in Organic and Analytical Chemistry discusses the concepts that are essential in the effective utilization of mass spectrometry. The title… Read more

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Advanced Mass Spectrometry: Applications in Organic and Analytical Chemistry discusses the concepts that are essential in the effective utilization of mass spectrometry. The title particularly covers the fundamentals of the modern techniques, along with the technological concerns of mass spectrometry. The opening chapter of the selection introduces mass spectrometry, while the subsequent chapters cover the fundamentals and hardware. The next chapters talk about the analytical chemistry consequences and the ion-genetic relationships. The remaining chapter covers the application of mass spectrometry, which includes structural, mechanistic, chemical, and biochemical applications. The book will be of great use to organic and analytical chemists. Chemists from other branch of chemistry, along with practitioners of related fields such as chemical engineering will also benefit from the text.

Preface

Chapter 1 Introduction

Chapter 2 Fundamentals

2.1 Ion Types

2.2 The Production of Ions

2.2.1 Ionization by Electron Impact

2.2.2 Chemical Ionization

2.2.3 Field Ionization

2.2.4 Collisional Activation (CA) or Collision Induced Dissociation(CID)

2.2.5 Metastable Ions

2.3 The Ion in a Mass Spectrometer

2.3.1 The Effect of a Magnetic Sector

2.3.2 The Effect of an Electric Sector

2.4 The Construction of a Mass Spectrometer

2.5 Ions with Deblocked Genetic Information

2.6 Primary Conditions for the Detection of Genetic Relationships between Ions

Chapter 3 Hardware

3.1 Single Focusing Mass Spectrometers

3.1.1 Magnetic Mass Spectrometers

3.1.2 Ion Kinetic Energy Spectrometry(IKES)

3.2 Double-Focusing Mass Spectrometers

3.2.1 Detection of Fragment Origin in the Second Field-Free Region

3.2.2 Detection of Origin and Fate of Ions in the First Field-Free Region

Chapter 5 Ion-Genetic Relationships

5.1 Presentation

5.2 Definitions

Chapter 6 Structural and Mechanistic Applications

6.1 Detection of Fragmentation Pathways

6.2 Elucidation of Ion Structures

6.2.1 Deduction of Ion Structures by Interpretation of Fragmentation Pathways

6.2.2 Analysis of Ion Structures by Collisional Activation

6.2.3 Analysis of Isomerizations

6.3 Detection of Rearrangements

6.3.1 The McLafferty Rearrangement

6.3.2 Single Proton Transfers after Elimination of a Neutral Particle

6.3.3 Rearrangements with Substituent Group Shifts

6.4 Analysis of Rearrangements Involving Ring Reactions

6.4.1 Ring Closing Reactions

6.4.2 Ring Expanding Reactions

6.4.3 Ring Contracting Reactions

6.4.4 Ring Opening Reactions

Chapter 7 Chemical and Biochemical Applications

7.1 Analysis of the Sequence in Oligomers

7.2 Test for Purity

7.3 Direct Analysis of Mixtures

7.3.1 Analysis of Mixtures by Detecting the Precursor Ions

7.3.2 Analysis of Mixtures by Detecting the Product Ions

7.3.3 Analysis of Mixtures of Isobaric Ions by High Resolution DADI/MIKE Spectrometry

7.3.4 Analysis of Mixtures of Isomeric

Compounds

References

Index