Advanced Heart Failure: from Pathophysiology to Clinical management, An Issue of Heart Failure Clinics

1st Edition, Volume 17-4 - September 16, 2021
Editors: Giuseppe Pacileo, Francesco Grigioni, Daniele Masarone, Luciano Potena
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 9 7 1 6 - 7
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 9 7 1 7 - 4

This issue of Heart Failure Clinics, guest edited by Drs. Giuseppe Pacileo, Daniele Masarone, Francesco Grigioni and Luciano Potena, will cover key topics in Advanced Heart… Read more

Advanced Heart Failure: from Pathophysiology to Clinical management, An Issue of Heart Failure Clinics

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This issue of Heart Failure Clinics, guest edited by Drs. Giuseppe Pacileo, Daniele Masarone, Francesco Grigioni and Luciano Potena, will cover key topics in Advanced Heart Failure: From Pathophysiology to Clinical Management. This issue is one of four issues selected each year by our series consulting editor, Dr. Eduardo Bossone. Topics discussed in this issue include (but are not limited to): Pathophysiology of advanced heart failure: what I need to know for clinical management?, Advanced heart failure: definition, epidemiology and clinical course, Echocardiography in advanced heart failure: beyond diagnosis, Disease modifier drugs in patients with advanced heart failure: How to optimize their use?, Congestion in patients with advanced heart failure: Assessment and treatment, Inotropes in patients with advanced heart failure: Not only palliative care, Cardiac resynchronization therapy and cardiac contractility modulation in patients with advanced heart failure: How to select the right candidate?, Mitral and tricuspid valves percutaneous repair in patients with advanced heart failure: Panacea, or Pandora's box?, Left ventricular assist device: Indication, timing and management, Listing criteria for heart transplant: Role of cardiopulmonary exercise test and of prognostic scores, Right heart catheterization in patients with advanced heart failure: when to perform, how to interpreter?, Advanced heart failure in special population: Cardiomyopathies, Advanced heart failure in special population: Pediatric age, Advanced heart failure in special population: Heart failure with preserved ejection fraction and Treatment of advanced heart failure: What future holds?.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Pathophysiology of Advanced Heart Failure: What Knowledge Is Needed for Clinical Management?
Key points
Neurohormonal and proinflammatory activation in advanced heart failure
Impaired cardiorespiratory reflex control
Fluid retention and congestion
Impaired cardiac contractility
Advanced heart failure: a multimorbid clinical syndrome
Clinics care points
Advanced Heart Failure: Definition, Epidemiology, and Clinical Course
Key points
Definition of advanced heart failure
Epidemiology
Clinical course
Clinics care points
Echocardiography in Advanced Heart Failure for Diagnosis, Management, and Prognosis
Key points
Introduction
Summary
Clinics care points
Disclosure statement
Disease-modifier Drugs in Patients with Advanced Heart Failure: How to Optimize Their Use?
Key points
Introduction
The pathophysiologic mechanisms of disease-modifier drugs in HFrEF
The clinical conditions influencing disease-modifier drugs in advanced heart failure
The evidence and the optimal use of renin angiotensin system and neprilysin inhibitors in advanced heart failure
Mineralocorticoid receptor antagonists and hyperkalemia in advanced heart failure
β-Blockers and heart rate in advanced heart failure
Type 2 sodium-glucose cotransporter inhibition In advanced heart failure
Summary
Clinics care points
Supplementary data
Congestion in Patients with Advanced Heart Failure: Assessment and Treatment
Key points
Introduction
Congestion and organ dysfunction in advanced heart failure
Assessment of congestion in advanced heart failure
Role of echocardiography, lung ultrasounds, and right heart catheterization to assess congestion in advanced heart failure
How to treat congestion in advanced heart failure
Summary
Clinics care points
Disclosure statement
Inotropes in Patients with Advanced Heart Failure: Not Only Palliative Care
Key points
Introduction
Classification of inotropes
Clinical pharmacology of inotropes
Inotropes in advanced heart failure
Repetitive infusion of levosimendan in patients with advanced heart failure
Summary
Clinics care points
Cardiac Resynchronization Therapy and Cardiac Contractility Modulation in Patients with Advanced Heart Failure: How to Select the Right Candidate?
Key points
Introduction
Cardiac resynchronization therapy
Cardiac contractility modulation
Patient selection for cardiac resynchronization therapy and cardiac contractility modulation
Clinics care points
Mitral and Tricuspid Valves Percutaneous Repair in Patients with Advanced Heart Failure: Panacea, or Pandora's Box?
Key points
Introduction
Prevalence and impact of secondary (functional) mitral regurgitation in stage C-D HFrEF
Mitral valve percutaneous repair
Transcatheter mitral valve replacement
Controversies
Prevalence and impact of secondary TR in advanced heart failure
Tricuspid valve percutaneous repair
Transcatheter tricuspid valve replacement
Controversies
Future directions: mitral and tricuspid valves percutaneous repair
Summary
Clinics care points
Left Ventricular Assist Device: Indication, Timing, and Management
Key points
Introduction
Indications
Preoperative evaluation
Perioperative management
Long-term management and complications
Left ventricular assist devices, transplantation, and end-of-life considerations in refractory heart failure patients
Clinics care points
Listing Criteria for Heart Transplant: Role of Cardiopulmonary Exercise Test and of Prognostic Scores
Key points
Introduction
Heart transplant
Prognostic stratification
Cardiopulmonary exercise test
Treatment effects
Peak volume of oxygen consumption adjusted values
Beyond peak volume of oxygen consumption
Multivariate approach combining cardiopulmonary exercise test variables
Specific considerations and future applications of cardiopulmonary exercise test for listing patients
Prognostic scores
Summary
Right Heart Catheterization in Patients with Advanced Heart Failure: When to Perform? How to Interpret?
Key points
Introduction
Right heart catheterization: best practices
Clinical applications of right heart catheterization
Right heart catheterization in acute heart failure
Right heart catheterization in the evaluation for advanced heart failure therapies
Right heart catheterization and left ventricular assist devices
Summary
Clinics care points
Advanced Heart Failure in Special Population: Cardiomyopathies and Myocarditis
Key points
Definition of cardiomyopathies
Hypertrophic cardiomyopathy
Restrictive cardiomyopathy
Arrhythmogenic ventricular cardiomyopathy
Left ventricular noncompaction cardiomyopathy
Myocarditis
Summary
Clinics care points
Advanced Heart Failure in Special Population—Pediatric Age
Key points
Introduction
Epidemiology
Etiology
Pathophysiology
Diagnosis
Medical Treatment and Device Therapy
Mechanic circulatory support
Heart transplantation
Summary
Clinics Care Points
Advanced Heart Failure in a Special Population: Heart Failure with Preserved Ejection Fraction
Key points
Introduction
Definition
Diagnosis
Causal diagnosis
Natural history and outcomes
Management and therapy
Summary
Clinics care points
Disclosure
Treatment of Advanced Heart Failure—Focus on Transplantation and Durable Mechanical Circulatory Support: What Does the Future Hold?
Key points
Background
Clinics care points