Advanced and Modern Approaches for Drug Delivery

1st Edition - July 29, 2023
Editors: Amit Kumar Nayak, Md Saquib Hasnain, Bibek Laha, Sabyasachi Maiti
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 6 6 8 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 7 2 1 9 - 2

Advanced and Modern Approaches for Drug Delivery explores novel approaches currently used for drug delivery, including the must up-to-date techniques and technology. The approa… Read more

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Advanced and Modern Approaches for Drug Delivery explores novel approaches currently used for drug delivery, including the must up-to-date techniques and technology. The approaches discussed allow pharmaceutical scientists to design effective drug delivery systems or devices for the management and treatment of numerous diseases and conditions. Detailed information on a wide variety of subjects, including dendrimers, lipid nanostructures, solid lipid nanoparticles, stimuli-responsive smart systems, self-assembled protein-drug nanoparticles, nanoconjugate formulations, nanofibers, iontophoretic systems, microneedle systems, ultra-sound triggered systems, targeted carrier-based intracellular delivery systems, resealed erythrocyte-based systems, 3 D-printing tool, site-specific monoclonal antibodies, and bio-inspired systems are all comprehensively discussed.

With contributions from those in academia and industry, this book is an excellent reference for all those needing to understand drug delivery systems.

Cover image
Title page
Table of Contents
Copyright
Contributors
Chapter 1. Novel drug delivery system
1. Introduction
2. Novel drug delivery system
3. Conclusion
Chapter 2. Self-emulsifying systems for drug delivery: advances and challenges
1. Introduction
2. Construction of pseudoternary phase diagrams
3. Self-emulsifying systems for oral drug delivery
4. Self-emulsifying ocular drug delivery systems
5. Self-emulsifying dermal and transdermal drug delivery systems
6. Self-emulsifying vaginal drug delivery systems
7. Self-emulsifying rectal drug delivery systems
8. Self-emulsifying parenteral drug delivery systems
9. Concluding remarks
Chapter 3. Gastroretentive drug delivery approaches: concepts, approaches, and applications
1. Introduction
2. Gastroretentive drug delivery systems
3. Anatomy and physiology of the stomach
4. Factors affecting gastric retention ability of a delivery system
5. Approaches to developing GRDDS
6. Swellable and expandable systems
7. Magnetic systems
8. Application of gastroretentive dosage forms
9. Conclusion
Chapter 4. Current advancements in nasopulmonary drug delivery systems
1. Introduction
2. Anatomy and physiology of the respiratory system
3. Advantages and limitations of the nasopulmonary route
4. Factors determining pulmonary drug distribution, effectiveness, and clearance
5. Materials selection for NPDDSSs
6. Applications of NPDDSs
7. Methods of targeting in NPDDSs
8. Next-generation impactor devices as lung simulators
Chapter 5. Osmotic drug deliverance systems: concepts, approaches, and applications
1. Introduction
2. Controlled drug deliverance by osmosis machineries
3. Concept of osmosis
4. Basic ingredients of osmotic machineries
5. Sorts of osmotically controlled drug deliverance devices
6. Conclusion
Chapter 6. Nanogels as drug delivery platform
1. Introduction
2. Bibliometric analysis of the nanogels as drug delivery platform
3. Drug release
4. Nanogels as a drug delivery platform in different systems
5. Other applications
6. Global market report
7. Disadvantages of the use of nanogels as drug carriers
8. Conclusions
Chapter 7. Nanoliposomes as safe and efficient drug delivery nanovesicles
1. Introduction
2. Nanoliposomes preparation
3. Methods of drug loading
4. Analysis and characterization of nanoliposomes
5. Types of nanoliposomes in drug delivery
6. Stability and safety of nanoliposomes
7. Applications of nanoliposomes in treatment of human diseases
8. Nanoliposomal vaccines
9. Nanoliposomal bioreactors
10. Nanoliposomes in theranostics
11. Marketed nanoliposomes and future challenges
12. Conclusions
Chapter 8. Transferosomes: a novel nanotechnological approach for transdermal drug delivery
1. Introduction
2. Transferosomes
3. Advantages of transferosomes
4. Limitations of transferosomes
5. Composition of transferosomes
6. Mechanism of penetration of transferosomes across stratum corneum
7. Methods of transferosome preparation
8. Characterizations of transferosomes
9. Applications of transferosomes
10. Conclusions
Chapter 9. Niosomes as a promising nanovesicular drug delivery
1. Introduction
2. Composition of niosomes
3. Factors affecting niosomal formulation
4. Types of niosomes
5. Fabrication methods of niosomes
6. Methods for controlling the size of niosomes
7. Niosome purification
8. Characterization of niosomes
9. Advantages and disadvantages of niosomes
10. Comparison of liposomes and niosomes
11. Pharmaceutical administration routes of niosomes
12. Applications of niosomes
13. Conclusions
Chapter 10. Cubosomes for enhanced drug delivery
1. Introduction
2. Main composition of the cubosomes
3. Preparation methods
4. Therapeutic applications of cubosomes and potential routes of administration
Chapter 11. Aquasomes: a novel nanocarrier system for drug delivery
1. Introduction
2. Aquasomes' structural components: the solid core
3. Aquasomes' structural components: the polyhydroxy oligomeric coating
4. Aquasomes' structural components: the bioactive molecule
5. Analytical tools for aquasomes' characterization
6. Aquasomes for the delivery of small molecules
7. Aquasomes for the delivery of proteins and peptides
8. Conclusions
Chapter 12. Phytosomes: a modernistic approach to the delivery of herbal drugs
1. Introduction
2. Methodology
3. Herbal medicine in drug discovery
4. Design of phytosomes' formulation
5. Phytosomes: preparation and applications
6. Biocompatibility and toxicity of phytosomes
7. Conclusions and future perspective
Chapter 13. Dendrimers in drug delivery
1. Introduction
2. Delivering drugs to the brain
3. Anticancer drugs
4. Antimicrobial agents
5. Conclusion
Chapter 14. Stimuli-responsive systems for smart drug delivery systems
1. Introduction
2. pH-responsive smart DDS
3. Redox-responsive smart DDS
4. Enzyme-responsive smart DDS
5. Thermoresponsive smart DDS
6. Magnetic-responsive smart DDS
7. Ultrasound-responsive smart DDS
8. Light-responsive smart DDS
9. Stimuli-sensitive smart DDS for combination therapy
10. Concluding remarks
Chapter 15. Self-assembled protein–drug nanoparticles for drug delivery
1. Introduction
2. Self-assembly
3. Collagen nanoparticles
4. Fabrication techniques of protein–drug nanoparticles for drug delivery
5. Conclusions
Chapter 16. Nanoconjugate formulations for enhanced drug delivery
1. Introduction
2. Drug conjugation strategies
3. Types of drug conjugate systems
4. Nanoconjugates for imaging
5. Nanoconjugates for conventional therapy
6. Nanoconjugates for nucleic acid therapy
7. Nanoconjugates for theranostic applications
8. Conclusion
Chapter 17. Nanofibers for drug delivery
1. Introduction
2. Fabrication of nanofibers
3. Drug delivery using nanofibers
4. Nanofibers for drug delivery applications
5. Nanofibers in clinical trials
6. Future prospective and conclusion
Chapter 18. Iontophoretic drug delivery: concepts, approaches, and applications
1. Introduction
2. Iontophoresis
3. Principles of iontophoresis
4. Iontophoretic electrochemistry
5. Various synergistic approaches with iontophoresis
6. Factors that influence iontophoretic administration of the drug
7. Ionic competition
8. Evaluation of iontophoretic drug delivery system
9. Application of iontophoresis
10. Miscellaneous applications of iontophoresis
11. Conclusion
Chapter 19. Microneedle systems for enhanced transdermal drug delivery
1. Introduction
2. Transdermal
3. Microneedles
4. Microneedle systems for enhanced transdermal drug delivery
5. Applications of microneedles transdermal
6. Conclusions
Chapter 20. Ultrasound-triggered drug delivery
1. Introduction
2. Ultrasound therapies using drug delivery systems
3. US drug delivery and release for functional vector medicines
4. US stimuli on drug release by hydrogel agents
Chapter 21. Resealed erythrocyte-based drug delivery
1. Introduction
2. Morphological and physiological description of erythrocytes
3. Source of erythrocytes
4. Drug loading of the erythrocytes
5. Characterization of erythrocytes
6. Administration routes of resealed erythrocytes
7. Storage of resealed erythrocytes
8. Erythrocytes application in drug delivery
9. Erythrocytes-based drug delivery of diverse drug classes
10. Resealed erythrocytes and nanomedicine
11. Nanoerythrosomes
12. Drug release from the erythrocytes
13. Clearance of resealed erythrocytes
14. Advantages of resealed erythrocytes application in drug delivery [6,93]
15. Disadvantages of resealed erythrocytes application in drug delivery [6,39,111,112]
16. Conclusion
Chapter 22. 3D-printing: a novel tool for personalized drug delivery
1. Introduction
2. 3D printing technologies
3. 3D printing in medicine
4. Types of dosage forms
5. Early-phase drug development and preclinical applications
6. Clinical opportunities
7. Novel drug delivery systems fabrication
8. Practical considerations using 3D printing technology
9. Challenges and future outlook
10. Conclusions
Chapter 23. Site-specific drug delivery utilizing monoclonal antibodies
1. Introduction
2. A primer of antibodies
3. Antibody–drug conjugates: the importance of being a linker
4. Payloads in ADCs
5. Conclusions
Chapter 24. Bio-inspired drug delivery systems
1. Polymers for drug delivery purposes
2. Hydrogels for drug delivery purposes
3. Advances in bio-inspired systems
4. Polymers for bio-inspired purposes
5. Research advances in bio-inspired drug delivery systems
6. Bio-inspired drug and gene delivery systems
7. Bio-inspired drug delivery for intracellular infections
8. Bio-inspired platform for repurposing conventional antibiotics purposes
9. Bio-inspired delivery for neuronal diseases
10. Summary
Chapter 25. Electronic drug delivery systems
1. Introduction
2. Microchip electronic drug delivery system
3. Electronic capsules drug delivery system
4. Electronic transdermal drug delivery
5. Electronic pumps
6. Electronic autoinjectors
7. Future prospects of electronic drug delivery systems
8. Conclusions
Chapter 26. Multifunctional nanocomposites for drug delivery applications
1. Introduction
2. Applications of the multifunctional nanocomposites in cancer
3. Gene therapy using multifunctional nanocomposites
Chapter 27. Periodontal drug delivery: advances and challenges
1. Introduction
2. Periodontal disease
3. Disinfectants, antibiotics, analgesics, and biphosphonates
4. Polymer matrix and inorganic filling materials
5. Periodontal pocket: devices for topical delivery
6. Conclusion
Chapter 28. Drug delivery for bone tissue engineering
1. Introduction
2. Bone tissue engineering
3. Bone scaffolds
4. Hydrogels
5. Bone adhesives
6. Drugs in bone tissue engineering
7. Drug delivery strategies in bone tissue engineering
8. Clinical applications
9. Concluding remarks
Chapter 29. Superparamagnetic iron oxide nanoparticles for drug delivery applications
1. Introduction
2. Synthesis and surface functionalization SPIONs
3. Drug loading to SPIONs
4. Drug delivery and release
5. Successes, challenges, and future prospects of SPIONs
6. Conclusions
Chapter 30. Metal-based drug delivery systems for cancer immunotherapy
1. Background
2. Cancer and immune systems
3. Conventional treatment strategies for cancer
4. Nanotechnology and cancer immunotherapy
5. Metal nanoparticle–based cancer immunotherapy
6. Mechanism of action of metal nanoparticles in immunotherapy
7. Challenges and future perspectives
8. Conclusion
Index

Amit Kumar Nayak

Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.

Affiliations and expertise

Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

Md Saquib Hasnain

Prof. (Dr.) Md Saquib Hasnain has over 10 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 70 publications in various high impact peer-reviewed journals, more than 100 book chapters and 16 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record in Google Scholar (h-index: 32). He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.

Affiliations and expertise

Department of Pharmacy, Palamau Institute of Pharmacy, Daltonganj, Jharkhand, India

Bibek Laha

Mr. Bibek Laha has an M.Pharm in Pharmaceutics from MAKAUT, with 8 years of teaching experience. Earlier he worked as a marketing executive in a pharmaceutical company for 2 years, later he shifted to research field; there he worked as research assistant for more than 3 years. He grabbed twice, first prize in poster presentation in AICTE sponsored national conference held at Gupta College of Technological Sciences, Asansol in the year 2012 & Bengal College of Pharmaceutical Sciences & Research (BCPSR) in collaboration with Association of Pharmacy Teachers of India (APTI), Bengal Branch, Durgapur in the year of 2014 respectively. He is a life member of Indian Science Congress Association (ISCA). He has successfully guided five post graduate students. He has 14 research publications in national & international journals. He has contributed 2 book chapters & worked as co-editor for international publishers.

Affiliations and expertise

Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, West Bengal, India

Sabyasachi Maiti

Sabyasachi Maiti is an M. Pharm, Ph.D from Jadavpur University, Kolkata, India. He is Associate Professor at the Department of Pharmacy, Indira Gandhi National Tribal University (Central University), Amarkantak, Madhya Pradesh, India. Dr Maiti has over 15 years experience in the field of pharmaceutical education and research. His research focusses on chemical modification of natural polysaccharides, characterization and their application in the design of novel drug delivery carriers. His research has been recognised by international peers in his field and he has more than 50 publications to his credit. He sits on numerous reviewer panels for international journals of repute, has edited multiple reference works and has written over 25 book chapters.

Affiliations and expertise

Department of Pharmacy, Indira Gandhi National Tribal University, Central University, Amarkantak, Madhya Pradesh, India