Adiponectin, Volume 90

1st Edition

Serial Editors: Gerald Litwack
Hardcover ISBN: 9780123983138
eBook ISBN: 9780123983190
Imprint: Academic Press
Published Date: 26th September 2012
Page Count: 480
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Table of Contents

Former Editors



Chapter One Lifestyle Factors Increasing Adiponectin Synthesis and Secretion

1 Introduction

2 Lifestyle Factors That Increase Adiponectin Synthesis and Secretion

3 Mechanisms for Lifestyle-Mediated Effects on Adiponectin

4 Conclusions

Chapter Two Molecular Tools to Characterize Adiponectin Activity

1 Introduction

2 Analysis of the Cellular Biology

3 Protein Structures

4 Searching for New Interaction Partners

5 Signaling Cascades and Physiological Effect

6 Conclusion

Chapter Three Nutritional and Hormonal Modulation of Adiponectin and its Receptors adipoR1 and adipoR2

1 Introduction

2 Nutritional Regulation of Adiponectin and Adiponectin Receptors

3 Hormonal Regulation of Adiponectin and Adiponectin Receptors

4 Conclusion

Chapter Four Regulation and Function of Adiponectin Receptors in Skeletal Muscle

1 Introduction

2 Adiponectin and Adiponectin Receptors

3 Adiponectin Signaling and Function in Skeletal Muscle

4 Transcriptional Regulation of AdipoRs in Skeletal Muscle Under Different Physiological and Pathophysiological Conditions

5 Molecular Mechanisms Regulating Muscle AdipoRs Transcription

6 Posttranscriptional Regulation of AdipoRs in Skeletal Muscle

7 Concluding Remarks

Chapter Five Screening for Adiponectin Secretion Regulators

1 Introduction

2 PPARγ-Dependent Adiponectin Secretion Regulators

3 PPAR γ-Independent Adiponectin Secretion Regulators

4 Other Adiponectin Secretion Regulators

5 Conclusions

Chapter Six Adiponectin and PPARγ

1 PPARγ Activity Correlates with Adiponectin Hormone Levels

2 PPARγ Regulates Adiponectin Gene Transcription

3 PPARγ Regulates Adiponectin Hormone Secretion

4 PPARγ and Adiponectin Regulate Simil


First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested


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About the Serial Editors

Gerald Litwack Serial Editor

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote “Human Biochemistry and Disease” a volume of 1254 pages. In 2007, he moved to Scranton,

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA