1st Edition - September 26, 2012

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  • Editor: Gerald Litwack
  • Hardcover ISBN: 9780123983138
  • eBook ISBN: 9780123983190

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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested

Table of Contents

  • Former Editors



    Chapter One Lifestyle Factors Increasing Adiponectin Synthesis and Secretion

    1 Introduction

    2 Lifestyle Factors That Increase Adiponectin Synthesis and Secretion

    3 Mechanisms for Lifestyle-Mediated Effects on Adiponectin

    4 Conclusions

    Chapter Two Molecular Tools to Characterize Adiponectin Activity

    1 Introduction

    2 Analysis of the Cellular Biology

    3 Protein Structures

    4 Searching for New Interaction Partners

    5 Signaling Cascades and Physiological Effect

    6 Conclusion

    Chapter Three Nutritional and Hormonal Modulation of Adiponectin and its Receptors adipoR1 and adipoR2

    1 Introduction

    2 Nutritional Regulation of Adiponectin and Adiponectin Receptors

    3 Hormonal Regulation of Adiponectin and Adiponectin Receptors

    4 Conclusion

    Chapter Four Regulation and Function of Adiponectin Receptors in Skeletal Muscle

    1 Introduction

    2 Adiponectin and Adiponectin Receptors

    3 Adiponectin Signaling and Function in Skeletal Muscle

    4 Transcriptional Regulation of AdipoRs in Skeletal Muscle Under Different Physiological and Pathophysiological Conditions

    5 Molecular Mechanisms Regulating Muscle AdipoRs Transcription

    6 Posttranscriptional Regulation of AdipoRs in Skeletal Muscle

    7 Concluding Remarks

    Chapter Five Screening for Adiponectin Secretion Regulators

    1 Introduction

    2 PPARγ-Dependent Adiponectin Secretion Regulators

    3 PPAR γ-Independent Adiponectin Secretion Regulators

    4 Other Adiponectin Secretion Regulators

    5 Conclusions

    Chapter Six Adiponectin and PPARγ

    1 PPARγ Activity Correlates with Adiponectin Hormone Levels

    2 PPARγ Regulates Adiponectin Gene Transcription

    3 PPARγ Regulates Adiponectin Hormone Secretion

    4 PPARγ and Adiponectin Regulate Similar Physiological Pathways

    5 Conclusion

    Chapter Seven Glucocorticoid Effects on Adiponectin Expression

    1 Introduction

    2 Glucocorticoids and Their Effects on Gene Expression

    3 Effects of GC and Adiponectin on Energy Metabolism

    4 In Vitro and Animal Studies on the Effects of GC on Adiponectin Expression

    5 Clinical Studies on the Effects of GC on Adiponectin Expression

    6 Other Hormones, Factors, and Conditions That Regulate Adiponectin Expression and Their Relationship to GC

    7 Potential Reasons for Contradictory Results on the Effects of GC on Adiponectin Expression and Methods That can be Useful in Gaining Better Insight About This Regulation

    8 Conclusion

    Chapter Eight Adiponectin and Reproduction

    1 Introduction

    2 Adiponectin and Adiponectin Signaling

    3 Adiponectin: Main Functions in Human

    4 Adiponectin and Steroidogenesis

    5 Adiponectin and Placental Functions

    6 Adiponectin and Pregnancy-Associated Pathologies

    7 Conclusions and Perspectives

    Chapter Nine Adiponectin and Its Receptors in Preimplantation Embryo Development

    1 Introduction

    2 Adiponectin and Fertility

    3 Overview of Preimplantation Embryo Development

    4 Expression of Adiponectin and Adiponectin Receptors in Oocytes and Preimplantation Embryos

    5 Potential Roles of Adiponectin in Oocyte and Early Embryo Development

    6 Conclusions

    Chapter Ten Adiponectin and the Control of Female Reproductive Functions

    1 Introduction

    2 Adiponectin in Ovarian Functions

    3 Adiponectin in Pregnancy

    4 Adiponectin Action on the Central Nervous System and the Pituitary Gland

    5 Conclusion

    Chapter Eleven Adiponectin in the Heart and Vascular System

    1 Introduction to Adiponectin

    2 Adiponectin and CVD in Humans

    3 Protective Effects of Adiponectin in the Cardiovascular System: Evidence from Rodent and In Vitro Studies

    4 Conclusions/Future Questions

    Chapter Twelve Adiponectin Interactions in Bone and Cartilage Biology and Disease

    1 Introduction

    2 Adipose, Bone, and Cartilage Relationships: Observations in Humans

    3 Adiponectin, Bone, and Cartilage: Interactions in Humans

    4 Adiponectin, Bone, and Cartilage: Experimental Observations

    5 Conclusions

    Chapter Thirteen Lipid-Lowering Drugs and Circulating Adiponectin

    1 Introduction

    2 Adiponectin

    3 Statins

    4 Fibrates

    5 Niacin

    6 Omega-3 Fatty Acids

    7 Conclusions

    Chapter Fourteen Adiponectin and Interleukin-6 in Inflammation-Associated Disease

    1 Introduction

    2 Biological Actions and Signaling Pathways Activated by Adiponectin

    3 Interaction Between Adiponectin and IL-6 in Regulating Diabetic State

    4 Interaction Between Adiponectin and IL-6 in Regulating Cardiovascular Disease

    5 Interaction Between Adiponectin and IL-6 in Regulating Autoimmune Disease

    6 Conclusion

    Chapter Fifteen New Insights into Anticarcinogenic Properties of Adiponectin

    1 Introduction

    2 Adiponectinemia

    3 Adiponectin and Breast Cancer Risk

    4 Adiponectin as Therapeutic Target

    5 Conclusion

    Chapter Sixteen Adiponectin

    1 Introduction

    2 Structure of APN: Similarity to Surfactant Proteins

    3 Expression and Regulation of APN in the Lung

    4 COPD-Like Phenotype in APN-KO Mice

    5 Mechanisms of COPD-Like Phenotype in APN-KO Mice

    6 Therapeutic Potential of APN

    7 Conclusion


Product details

  • No. of pages: 480
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: September 26, 2012
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123983138
  • eBook ISBN: 9780123983190

About the Serial Editor

Gerald Litwack

Gerald Litwack
Dr. Gerald Litwack obtained M.S. and PhD degrees from the University of Wisconsin Department of Biochemistry and remained there for a brief time as a Lecturer on Enzymes. Then he entered the Biochemical Institute of the Sorbonne as a Fellow of the National Foundation for Infantile Paralysis. He next moved to Rutgers University as an Assistant Professor of Biochemistry and later as Associate Professor of biochemistry at the University of Pennsylvania Graduate School of Medicine. After four years he moved to the Temple University School of Medicine as Professor of Biochemistry and Deputy Director of the Fels Institute for Cancer Research and Molecular Biology, soon after, becoming the Laura H. Carnell Professor. Subsequently he was appointed chair of Biochemistry and Molecular Pharmacology at the Jefferson Medical College as well as Vice Dean for Research and Deputy Director of the Jefferson Cancer Institute and Director of the Institute for Apoptosis. Following the move of his family, he became a Visiting Scholar at the Department of Biological Chemistry of the Geffen School of Medicine at UCLA and then became the Founding Chair of the Department of Basic Sciences at the Geisinger Commonwealth School of Medicine, becoming Professor of Molecular and Cellular Medicine and Associate Director of the Institute for Regenerative Medicine at the Texas A&M Health Science Center as his final position. During his career he was a visiting scientist at the University of California, San Francisco and Berkeley, Courtauld Institute of Biochemistry, London and the Wistar Institute. He was appointed Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine. He has published more than 300 scientific papers, authored three textbooks and edited more than sixty-five books. Currently he lives with his family and continues his authorship and editorial work in Los Angeles.

Affiliations and Expertise

Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine, USA; Toluca Lake, North Hollywood, California, USA

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