Gene therapy is gaining recognition as an exciting new therapeutic technique with great potential for the treatment of disease. Gene delivery vehicles, or vectors, based on the adenovirus are emerging as important tools in gene therapy. About one in ten people has, or will develop at some later stage, an inherited genetic disorder, and approximately 2800 specific conditions are known to be caused by defects (mutations) in just one of the patient's genes. To date, gene therapy techniques have not proved as successful in treating these disorders as originally hoped. Making gene therapy a successful endeavor will require careful research to improve traditional approaches and explore new ways to deal with genetic defects. One such innovative technique is the use of retroviruses and adenoviruses to deliver genes to cells without disrupting the cell's chromosomal configuration.
Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors.
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- © Academic Press 2003
- 1st May 2002
- Academic Press
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"This is a well organized collection of reviews written by authorities in the field that covers key aspects in the use of adenovirus as a gene transfer vehicle. The complete coverage of so many different aspects of adenovirus vector biology will be invaluable to scientists beginning or well established in this rapidly changing field." --DOODY'S (March 2003)