Adenosine Receptors and Parkinson's Disease

This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. This book covers how the Parkinson's disease antagonist drug, A2A, has been researched, developed, and tested. It is an essential book for researchers interested in the basal ganglia, purine biology, and Parkinson's Disease.

• Discusses the discovery and development of a novel non-dopaminomimetic agent for Parkinson's disease
• Provides the first definitive overview of adenosine antagonists and their role in the treatment of Parkinson's disease
• Presents a new mechanism of action of adenosine A2A receptor antagonists in motor function
  Proposes a hypothesis of adenosine A2A receptor function in the striatum
• Comprehensive overview of adenosine, its receptor subtypes, their antagonists/agonists from biochemistry, molecular biology, medicinal chemistry, physiology, pharmacology, and neurochemistry viewpoints

Neuroscientists, neurologists, pharmacologists, biochemists, and geneticists, especially all workers in the basal ganglia, purine, and Parkinson's fields

H. Kase, Introductory Remarks: Adenosine A2A Receptor Antagonists: A Novel Approach to the Treatment of Parkinson's Disease.

S.J. Augood, P.C. Emsom, and D.G. Standaert, Localisation of Adenosine Receptors in Brain and Periphery.

J. Shimada and F. Suzuki, Medicinal Chemistry of Adenosine Receptors in Brain and Periphery.

A. Karasawa, Overview of the Physiology and Pharmacology of Adenosine in the Peripheral System.

H. Nonaka and M. Ichimura, Biochemical Characterizatoin of Adenosine Agonists and Antagonists.

A. Mori and T. Shindou, Physiology of Adenosine Receptors in the Striatum: Regulation of Striatal Projection Neurons.

P. Richardson and M. Kurokawa, The Regulation of Neurotransmitter Release in Basal Ganglia by Adenosine Receptor Agonists and Antagonists in Vitro and in Vivo.

A. Dixon and P. Richardson, Control of Gene Expression in the Basal Ganglia Induced by Adenosine Receptors.

S. Aoyama, J.-H. Baik, H. Kase, and E. Borrelli, Knockout Mice in the Study of Dopaminergic Diseases.

S. Shiozaki, S. Ichikawa, J. Nakamura, and Y. Kuwana, Effects of Adenosine Receptors Experimental Models of Cognition and Motor Behaviour.

T. Kanda and P. Jenner, Actions of Adenosine Antagonists in a Primate Model of Parkinson's Disease.

A. Tahar, R. Grondin, L. Gregoire, A. Mori, H. Kase, and P.J. Bedard, Selective Adenosine A2A Receptor Antagonism as an Alternative Therapy for Parkinson's Disease: A Study in Nonhuman Primates.

M. Nomoto, Neurobiology of Adenosine Receptors: Adenosine and its Metabolites in Movement Disorders.