Actin Cytoskeleton in Cancer Progression and Metastasis - Part B

Actin Cytoskeleton in Cancer Progression and Metastasis - Part B

1st Edition - October 12, 2020

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  • Editors: Lorenzo Galluzzi, Clement Thomas
  • eBook ISBN: 9780128212844
  • Hardcover ISBN: 9780128212837

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Description

Actin Cytoskeleton in Cancer Progression and Metastasis (Part B), Volume 356 in the  International Review of Cell and Molecular Biology series, provides an overview on the roles of the actin cytoskeleton and its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, and in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. Specific chapters in this release cover Actin dynamics during tumor cell dissemination, Actin cytoskeleton remodeling during cancer cell migration, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and much more.

Key Features

  • Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology
  • Offers a wide range of perspectives for basic and translational research
  • Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications

Readership

Advanced undergraduates, graduates, academics and researchers in the area of cancer biology

Table of Contents

  • 1. Actin dynamics during tumor cell dissemination
    Jose J. Bravo-Cordero
    2. Actin cytoskeleton remodeling during cancer cell migration
    Antonina Alexandrova
    3. Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer
    Michelle Dawson
    4. The many roles of actin in the nucleus
    Stefan Zahler
    5. The emerging role of nuclear actin and myosin in the transcriptional response to DNA damage
    Piergiorgio Percipalle
    6. The microenvironment and cytoskeletal remodeling in tumor cell invasion
    Tafazzoli Shadpour
    7. Mechanics of actin filaments in cancer onset and progress
    Tafazzoli Shadpour
    8. Actin cytoskeleton regulators at invadopodia
    Clement Thomas
    9. Novel facets of Glioblastoma invasion
    Simone Niclou

Product details

  • No. of pages: 330
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: October 12, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128212844
  • Hardcover ISBN: 9780128212837

About the Serial Volume Editors

Lorenzo Galluzzi

Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.

Affiliations and Expertise

Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA

Clement Thomas

Clément Thomas is holding a group leader position at the Department of Oncology of the Luxembourg Institute of Health (LIH; Luxembourg City, Luxembourg). He received his PhD in Molecular and Cellular Biology in 2003 from Strasbourg University (France) in 2003. Since that moment, he has been interested in cell plasticity with a particular focus on actin cytoskeleton remodeling mechanisms. After more than ten years working with plant models, he joined the department of Oncology of LIH and established a group focused on the functions of the actin cytoskeleton in two central and complementary processes underlying cancer progression: invasion and immune evasion. Clément Thomas and his colleagues characterized a family of small, evolutionary-conserved, LIM domain-containing proteins (cysteine and glycine-rich proteins) that crosslink actin filaments into stable actin bundles and established the role of these proteins in promoting the formation and activity of invadopodia in breast cancer cells. Lately, Clément Thomas’ group has initiated a pioneering study aimed at elucidating the role of the cancer cell’s actin cytoskeleton during immune evasion.

Affiliations and Expertise

Group Leader, Department of Oncology of the Luxembourg Institute of Health, LIH; Luxembourg City, Luxembourg

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