Acetylcholine in Alzheimer’s Disease and Related Dementias

Acetylcholine in Alzheimer’s Disease and Related Dementias

1st Edition - December 1, 2022

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  • Authors: Laszlo Zaborszky, Saak Ovsepian
  • Paperback ISBN: 9780128244913

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Description

Acetylcholine in Alzheimer’s Disease and Related Dementias surveys the current state of knowledge on the cholinergic system in rodents, primates and humans. The book's authors discuss aging and AD from system, cellular, molecular and genetic aspects. The book critically evaluates the role of the cholinergic system as it relates to clinical symptoms, therapy and pathogenesis. It follows the history of the cholinergic hypothesis of memory and AD from the seventies/early eighties of the previous century to the current view of disease-modifying roles. The book promotes the idea that the organization of the cholinergic system and its purported homeostatic role may contribute to its higher vulnerability to amyloid pathology of AD.Finally, it discusses current trends of AD prevention from a functional medicine perspective.

Key Features

  • Offers a comprehensive overview on the current state of knowledge on Alzheimer’s and the cholinergic system
  • Discusses basic molecular, cellular and system level data on the basal forebrain cholinergic system and how the data relates to AD
  • Synthesizes basic science such as anatomy, electrophysiology, pharmacology and genetics, with translational data from neurology, psychiatry and cognitive neuroscience

Readership

Researchers, advanced graduate students, and clinicians in neuroscience, psychiatry and neurorehabilitation

Table of Contents

  • 1. Anatomy of the basal forebrain cholinergic (BFC) system in rodents and primates, including humans
    2. Input-output relations of BFC neurons
    3. Cholinergic receptors: neurobiology and functions
    4. Dementias
    5. Neuropathology of AD
    6. Cholinergic deficit in AD
    7. Relationship between cholinergic loss, pathological lesions in AD and dementia
    8. Progression of the disease, clinical-pathological correlations in MCI/AD
    9. Pathology of the aging brain in relation to AD
    10. Amyloid deposition with large-scale human network dysfunctions in aging and AD
    11. APP processing, β-amyloid, α,β,γ secretases, notch signaling
    12. Β-amyloid production, secretion, oligomerization, clearance/export, degradation
    13. Synaptic vesicle cycle and β-amyloid: intracellular trafficking, retromer sorting, autophagy
    14. Tau phosphorylation, NFTs, axonal transport
    15. The wnt-GSK-3 signaling, presenilin, tau
    16. Apolipoprotein, LRP receptors, lipid homeostasis
    17. ApoE alleles, gene mutations in AD
    18. Microglia activation, inflammation
    19. Epigenetic mechanisms in AD
    20. Transgenic mice models in AD
    21. Pathogenetic (mechanistic) schemes
    22. Current therapies in AD
    23. Vulnerability and repair of BFC neurons, early attempts
    24. Biochemical pathways linking muscarinic, nicotinic receptors with APP cleavage and phosphorylation of tau
    25. NGF, TrkA, p75, neurobiology, transport and signaling in cholinergic neurons
    26. Homeostatic clearance of Aβ mediated via p75 receptor uptake and degradation in BFC neurons
    27. Cell cycle proteins in BFC cells
    28. Dual, neuromodulator and homeostatic role of BFC system
    29. Atrophy of BFC compartments and relation to cognitive impairment in MCI/AD
    30. Volume of Ch1/2 is predictor of conversion from MCI to AD
    31. Summary and concluding remarks

Product details

  • No. of pages: 350
  • Language: English
  • Copyright: © Academic Press 2024
  • Published: December 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128244913

About the Authors

Laszlo Zaborszky

Dr. Zaborszky MD, PhD is a Distinguished Professor of Neuroscience at Rutgers University. He is the founding Editor-in-Chief of Brain Structure and Function. Author of over 115 scientific papers, book chapters and a monograph. His work on the basal forebrain cholinergic system has greatly advanced in the field of neural basis of attention and cognition, as well as basic and translational research of Alzheimer’s and Parkinson’s diseases. His research received generous support from the NIH/NINDS for over 28 years. He was President, New York Hungarian Scientific Society (2012-2016), President, Association of American Hungarian Academicians (2018-2020), Foreign Member of the Hungarian Academy of Sciences (HAS, 2007-); Board of Trustees Award for Research Excellence (President, Rutgers University, 2016), The Knight Cross, Order of Merit (President of Hungary, 2013). Chair of the Newark Faculty Council of Rutgers University (2016/2017).

Affiliations and Expertise

Professor of Neuroscience, Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, USA

Saak Ovsepian

Dr. Ovsepian MD, PhD is Professor of Neurobiology, Director of the Research Program, Head of the Department of Experimental Neurobiology at the National Institute of Mental Health, Prague, Czech Republic. He is a Faculty Member of the Department of Psychiatry and Medical Psychology, Charles University, Prague, Czech Republic. Prof. Ovsepian is also Adjunct Professor at the Department of Biotechnology, Faculty of the Sciences and Health, Dublin City University, Dublin, Republic of Ireland. He is author of over 70 peer reviewed papers and several book chapters on synaptic biology, neurophysiology, neuropsychiatric and neurodegenerative diseases, and developing new methods for brain imaging. He is Member of Board of Directors Dublin City University (2009-2012) and Member of the Board of Directors of the National Institute of Mental Health (2018-2020), Czech Republic.

Affiliations and Expertise

Professor, Head of Department of Experimental Neurobiology, National Institute of Mental Health Klecany, Czech Republic

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