Description

This practical, easy-to-use guide, named to Doody’s Core Titles 2013, addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care.

Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management.

Key Features

  • Named to Doody’s Core Titles 2013, a collection development tool for health sciences libraries of all sizes, by Doody Enterprises
  • Practical information for both clinicians and laboratory scientists, presented in the form of tables and charts for easy reference
  • Focus on range and sources of interferences rather than details of toxicologic mechanisms which are well covered in toxicology textbooks
  • Covers interferences across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing

Readership

Pathologists, clinical chemists, and toxicologists; practicing clinicians, fellows and residents in pathology, internal medicine, emergency medicine and family practice.

Table of Contents

Foreword

Preface

List of Contributors

Chapter 1. Variation, Errors, and Quality in the Clinical Laboratory

Introduction

Errors in the Clinical Laboratory

Quality Improvement in the Clinical Laboratory

Conclusions

References

Chapter 2. Effect of Age, Gender, Diet, Exercise, and Ethnicity on Laboratory Test Results

Introduction

Effects of Age-Related Changes on Clinical Laboratory Test Results

Effects of Gender-Related Changes on Clinical Laboratory Test Results

Effects of Diet on Clinical Laboratory Test Results

Effects of Nutraceuticals on Clinical Laboratory Test Results

Effects of Exercise on Clinical Laboratory Test Results

Effects of Ethnicity/Race on ClinicaL Laboratory Test Results

Conclusions

References

Chapter 3. Effect of Patient Preparation, Specimen Collection, Anticoagulants, and Preservatives on Laboratory Test Results

Introduction

Biological Rhythms and Laboratory Test Results

Issues of Patient Preparation

Differences Between Whole Blood, Plasma, and Serum Specimens for Clinical Laboratory Analysis

Different Anticoagulants and Preservatives, Order of Draw, Problems with Gel Interference in Serum Separator Tubes, and Short Draws

Order of Draw of Various Blood Collection Tubes

Collection Sites; Differences Between Arterial, Capillary, and Venous Blood Samples; and Problems with Collections from Catheters and Intravenous Lines

Urine Collection, Timing, and Techniques

Conclusions

References

Chapter 4. Sample Processing and Specimen Misidentification Issues

Introduction

Transportation

The Effects of Centrifugation on Laboratory Results

Effect of Storage Conditions on Laboratory Results

Effect of Cross-Contamination of Specimens on Laboratory Results

Consequences of Specim

Details

No. of pages:
382
Language:
English
Copyright:
© 2013
Published:
Imprint:
Elsevier
Print ISBN:
9780124157835
Electronic ISBN:
9780124158580

About the authors

Amitava Dasgupta

Amitava Dasgupta received his PhD degree in Chemistry from Stanford University and his fellowship training in Clinical Chemistry from the Laboratory Medicine Department of the University of Washington School of Medicine at Seattle. He is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center located at the Texas Medical Center at Houston. Dr. Dasgupta has published 210 scientific papers, written many invited review articles, and has edited, co-edited or written 15 books. He is on the Editorial Board of five major medical journals including American Journal of Clinical Pathology, Archives of Pathology and Laboratory Medicine, Therapeutic Drug Monitoring, Clinica Chimica Acta and Journal of Clinical Laboratory Analysis.

Affiliations and Expertise

Professor, Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX, USA

Jorge Sepulveda

Jorge Sepulveda received his M.D. from the University of Lisbon, Portugal, and his residency training in Laboratory Medicine and Ph.D. degree in Cell and Molecular Biology from Baylor College of Medicine, Houston, Texas. He is board certified by the American Board of Pathology in Clinical Pathology and Transfusion Medicine. He has published over 35 research articles, review papers and book chapters, and serves as Associate Editor for the Archives of Pathology and Laboratory Medicine. Dr. Sepulveda has broad experience in laboratory medicine as medical director of various clinical laboratories, including at the Houston and Philadelphia Veterans Affairs Medical Centers and at the University of Pittsburgh Presbyterian and Shadyside Hospitals, and currently serves as Associate Medical Director of the Clinical Laboratories at the Columbia University Medical Center Campus of New York-Presbyterian Hospital.

Affiliations and Expertise

Associate Professor and Associate Director of Laboratory Medicine, Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA

Awards

Doody’s Core Titles 2013, Doody Enterprises

Reviews

"Dasgupta and Sepulveda offer clinicians and laboratory scientists a guide to error detection and correction in the clinical laboratory that addresses sources of errors in analytical methods and sources of pre-analytical variation."--Reference and Research Book News, August 2013
"This is a very helpful book correlating nonanalytical measurement errors or disease states with anticipated effects on laboratory test results. This would be a must for the laboratory medicine resident who has to explain why results don't correlate with clinical disease."--Doody.com, August 9, 2013