Description

ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated.

Key Features

Key Features * Phylogeny and Evoloution of ABC Transporters * Fundamental Aspects of the Mechanism of Action of ABC Transporters * Prokaryote ABC Transporters * Non-Mammalian Transporters * Multidrug Transporters * ABC Transporters, Physiological Roles and Human Disease * Full color throughout

Readership

Biochemists, microbiologists, molecular biologists, cell biologists, and geneticists

Table of Contents

CONTRIBUTORS

THE EDITORS

ABC TRANSPORTERS: AN INTRODUCTION AND OVERVIEW

PART I: PHYLOGENY AND EVOLUTION OF ABC TRANSPORTERS

Chapter 1: PHYLOGENETIC AND FUNCTIONAL CLASSIFICATION OF ABC (ATP-BINDING CASSETTE) SYSTEMS

INTRODUCTION

INVENTORY AND CLASSIFICATION OF ABC SYSTEMS

FAMILIES OF ABC SYSTEMS IN LIVING ORGANISMS

LESSONS FROM GENOME COMPARISONS

CONCLUSIONS AND PERSPECTIVES

Chapter 2: MEMBRANE TOPOLOGY OF THE HUMAN ABC TRANSPORTER PROTEINS

INTRODUCTION

METHODOLOGY

MEMBRANE TOPOLOGY OF THE ABC TRANSPORTERS

CONCLUSIONS

Chapter 3: HUMAN AND DROSOPHILA ABC PROTEINS

INTRODUCTION

PHYLOGENETIC ANALYSIS OF HUMAN ABC GENES

DROSOPHILA ABC GENES

HUMAN ABC GENE SUBFAMILIES

CONCLUSIONS AND PERSPECTIVES

PART II: FUNDAMENTAL ASPECTS OF THE MECHANISM OF ACTION OF ABC TRANSPORTERS

Chapter 4: STRUCTURE OF ABC TRANSPORTERS

INTRODUCTION

STRUCTURES OF NBDS

STRUCTURES OF INTACT ABC TRANSPORTERS

CONCLUSIONS

ACKNOWLEDGMENTS

Chapter 5: SUBSTRATE-BINDING SITES IN ABC TRANSPORTERS

GENERAL INTRODUCTION

PROPERTIES OF SUBSTRATES RECOGNIZED BY ABC TRANSPORTERS

LOCATION(S) AND NUMBER OF SUBSTRATE-BINDING SITES IN ABC TRANSPORTERS

STRUCTURAL AND FUNCTIONAL PROPERTIES OF SUBSTRATE-BINDING SITES

COUPLING BETWEEN SUBSTRATE-BINDING SITES AND NUCLEOTIDE-BINDING DOMAINS

THE TRANSPORT CYCLE OF ABC TRANSPORTERS

CONCLUDING REMARKS

ACKNOWLEDGMENTS

Chapter 6: PROBING OF CONFORMATIONAL CHANGES, CATALYTIC CYCLE AND ABC TRANSPORTER FUNCTION

INTRODUCTION

THE CATALYTIC CYCLE OF PGP AND OTHER ABC TRANSPORTERS – AN OVERVIEW

VACUUM CLEANER MODEL FOR ABC MULTIDRUG TRANSPORTERS

PROBING CONFORMATIONAL CHANGES OF PGP DURING THE CATALYTIC CYCLE

CONFORMATIONAL CHANGES IN OTHER

Details

No. of pages:
530
Language:
English
Copyright:
© 2003
Imprint:
Academic Press
Print ISBN:
9780123525512
Electronic ISBN:
9780080481876

Reviews

"...the volume unquestionably succeeds overall as an in-depth survey of both the biology and the biochemistry of a ubiquitous and astonishingly diverse family of very complex enzymes. Every group with an interest in these proteins should own a copy." -CELL (July 2003) "The editors of ABC Proteins: From Bacteria to Man have valiantly attempted to encompass in this volume the entire scope of research on these proteins, from atomic-resolution structure to human genetic diseases, and from Escherichia coli to Homo sapiens and Arabidopsis thaliana... What the book makes obvious is that nearly all ABC proteins are membrane localized, ATP dependent, primary active transporters...In addition to advances in our understanding of ABC transporter structure, several chapters in the book also describe progress that has been made in elcuidating the mechanisms of transport. The volume unquestionably succeeds overall as an in-depth survey of both the biology and the biochemistry of a ubiquitous and astoundingly diverse family of very complex enzymes. Every group with an interest in these proteins should own a copy. Finally, this book makes a convincing case that many laboratories that may not yet suspect it will soon have a much more abiding interest in ABC proteins." "...well organized and included beautifully clear color images and figures." -E STREAMS (July 2003)