ABC Proteins

ABC Proteins

From Bacteria to Man

1st Edition - January 7, 2003

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  • Editors: I Barry Holland, Susan Cole, Karl Kuchler, Christopher Higgins
  • eBook ISBN: 9780080481876

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Description

ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated.

Key Features

  • Phylogeny and Evoloution of ABC Transporters
  • Fundamental Aspects of the Mechanism of Action of ABC Transporters
  • Prokaryote ABC Transporters
  • Non-Mammalian Transporters
  • Multidrug Transporters
  • ABC Transporters, Physiological Roles and Human Disease
  • Full color throughout

Readership

Biochemists, microbiologists, molecular biologists, cell biologists, and geneticists

Table of Contents

  • CONTRIBUTORS

    THE EDITORS

    ABC TRANSPORTERS: AN INTRODUCTION AND OVERVIEW

    PART I: PHYLOGENY AND EVOLUTION OF ABC TRANSPORTERS

    Chapter 1: PHYLOGENETIC AND FUNCTIONAL CLASSIFICATION OF ABC (ATP-BINDING CASSETTE) SYSTEMS

    INTRODUCTION

    INVENTORY AND CLASSIFICATION OF ABC SYSTEMS

    FAMILIES OF ABC SYSTEMS IN LIVING ORGANISMS

    LESSONS FROM GENOME COMPARISONS

    CONCLUSIONS AND PERSPECTIVES

    Chapter 2: MEMBRANE TOPOLOGY OF THE HUMAN ABC TRANSPORTER PROTEINS

    INTRODUCTION

    METHODOLOGY

    MEMBRANE TOPOLOGY OF THE ABC TRANSPORTERS

    CONCLUSIONS

    Chapter 3: HUMAN AND DROSOPHILA ABC PROTEINS

    INTRODUCTION

    PHYLOGENETIC ANALYSIS OF HUMAN ABC GENES

    DROSOPHILA ABC GENES

    HUMAN ABC GENE SUBFAMILIES

    CONCLUSIONS AND PERSPECTIVES

    PART II: FUNDAMENTAL ASPECTS OF THE MECHANISM OF ACTION OF ABC TRANSPORTERS

    Chapter 4: STRUCTURE OF ABC TRANSPORTERS

    INTRODUCTION

    STRUCTURES OF NBDS

    STRUCTURES OF INTACT ABC TRANSPORTERS

    CONCLUSIONS

    ACKNOWLEDGMENTS

    Chapter 5: SUBSTRATE-BINDING SITES IN ABC TRANSPORTERS

    GENERAL INTRODUCTION

    PROPERTIES OF SUBSTRATES RECOGNIZED BY ABC TRANSPORTERS

    LOCATION(S) AND NUMBER OF SUBSTRATE-BINDING SITES IN ABC TRANSPORTERS

    STRUCTURAL AND FUNCTIONAL PROPERTIES OF SUBSTRATE-BINDING SITES

    COUPLING BETWEEN SUBSTRATE-BINDING SITES AND NUCLEOTIDE-BINDING DOMAINS

    THE TRANSPORT CYCLE OF ABC TRANSPORTERS

    CONCLUDING REMARKS

    ACKNOWLEDGMENTS

    Chapter 6: PROBING OF CONFORMATIONAL CHANGES, CATALYTIC CYCLE AND ABC TRANSPORTER FUNCTION

    INTRODUCTION

    THE CATALYTIC CYCLE OF PGP AND OTHER ABC TRANSPORTERS – AN OVERVIEW

    VACUUM CLEANER MODEL FOR ABC MULTIDRUG TRANSPORTERS

    PROBING CONFORMATIONAL CHANGES OF PGP DURING THE CATALYTIC CYCLE

    CONFORMATIONAL CHANGES IN OTHER ABC TRANSPORTERS

    DOMAIN INTERACTIONS IN ABC TRANSPORTERS

    Chapter 7: X-RAY STRUCTURE OF AN INTACT ABC TRANSPORTER, MSBA

    INTRODUCTION: THE MULTIDRUG RESISTANCE (MDR) ABC TRANSPORTERS

    STRUCTURAL STUDIES OF MDR-ABC TRANSPORTERS

    PROTEIN EXPRESSION

    PROTEIN PURIFICATION

    PROTEIN CRYSTALLIZATION

    CRYSTALLOGRAPHIC ANALYSIS

    STRUCTURE DESCRIPTION

    POSSIBLE FLIPPING MECHANISM

    ACKNOWLEDGMENTS

    PART III: PROKARYOTE ABC TRANSPORTERS

    Chapter 8: INTRODUCTION TO BACTERIAL ABC PROTEINS

    NATURE AND COMPOSITION OF THE ABC TRANSPORTER

    AN ABUNDANCE OF DIFFERENT TYPES OF ABC PROTEINS IN PROKARYOTES

    AN ADDITIONAL CLASS OF BACTERIAL ABCs INVOLVED IN DNA RECOMBINATION AND REPAIR

    EXPORTERS

    CLASS 2, ORPHAN ABCS

    IMPORTERS

    MEMBRANE DOMAINS OF THE BACTERIAL TRANSPORTERS ARE POORLY UNDERSTOOD

    STRUCTURE AND FUNCTION OF THE ABC TRANSPORTERS

    Chapter 9: IMPORT OF SOLUTES BY ABC TRANSPORTERS – THE MALTOSE AND OTHER SYSTEMS

    INTRODUCTION AND GENERAL OVERVIEW

    THE MALTOSE/MALTODEXTRIN TRANSPORT SYSTEM OF E. COLI AND S. TYPHIMURIUM

    CURRENT TRANSPORT MODELS

    CONCLUSIONS AND PERSPECTIVES

    ACKNOWLEDGMENTS

    Chapter 10: CRYSTAL STRUCTURES OF PERIPLASMIC SOLUTE-BINDING PROTEINS IN ABC TRANSPORT COMPLEXES ILLUMINATE THEIR FUNCTION

    INTRODUCTION

    STRUCTURE AND SUBSTRATE BINDING

    LIGAND BINDING

    INTERACTIONS OF PBPS WITH MEMBRANE COMPONENTS

    EVOLUTION OF PERIPLASMIC BINDING PROTEINS

    PROTEINS WITH RELATED FOLDS TO THE PBPS

    PERSPECTIVES

    ACKNOWLEDGMENT

    Chapter 11: BACTERIAL ABC TRANSPORTERS INVOLVED IN PROTEIN TRANSLOCATION

    INTRODUCTION

    PHYLOGENY OR CLUSTER ANALYSIS OF THE ABC-ATPASE INVOLVED IN TYPE 1 SECRETION

    GENETIC BASIS OF THE TYPE 1 SECRETION SYSTEM

    PROMISCUITY OF THE ABC SECRETION SYSTEM

    ALLOCRITES FOR TYPE 1 SECRETION SYSTEMS

    TYPE 1 SECRETION OF LARGE POLYPEPTIDES INVOLVES A C-TERMINAL TARGETING SIGNAL

    THE RTX SECRETION SIGNAL HAS A DUAL FUNCTION

    SEVERAL ANTIBACTERIAL PEPTIDES SECRETED VIA THE TYPE 1 SYSTEM EMPLOY AN N-TERMINAL TARGETING SIGNAL

    COMPOSITION OF THE TYPE 1 SECRETION TRANSLOCATOR

    BOTH MFP AND ABC COMPONENTS OF THE TYPE 1 TRANSLOCATOR MAY BE INVOLVED IN RECOGNITION OF THE SECRETION SIGNAL OF THE TRANSPORT SUBSTRATE

    GENERAL ORGANIZATION OF ABC TRANSPORTERS FOR TYPE 1 SECRETION: SOME HAVE A SPECIFIC PROTEASE DOMAIN

    TOPOLOGY OF THE MEMBRANE DOMAIN OF HLYB

    GENETIC ANALYSIS OF HLYB.

    ATTEMPTS TO PURIFY THE INTACT ABC TRANSPORTER ASSOCIATED WITH TYPE 1 SECRETION

    PROPERTIES OF THE PURIFIED ABC DOMAIN

    THE FORM OF TYPE 1 PROTEINS DURING TRANSLOCATION: FOLDED OR UNFOLDED?

    WHAT ROLE FOR HLYB IN THE TRANSLOCATION OF HLYA?

    STRUCTURE OF THE ABC DOMAIN OF HLYB AND OTHER ABC PROTEINS: SEARCHING FOR REGIONS RELATING TO SPECIFICITY/IDENTITY

    MODEL FOR SECRETION OF TYPE 1 ALLOCRITES

    ACKNOWLEDGMENTS

    Chapter 12: BACTERIAL MULTIDRUG RESISTANCE MEDIATED BY ABC TRANSPORTERS

    INTRODUCTION

    PROPERTIES OF LMRA AND HORA

    STRUCTURAL CHANGES INDUCED BY NUCLEOTIDE BINDING OR HYDROLYSIS DETECTED BY ATR-FTIR SPECTROSCOPY

    COUPLING OF ATP HYDROLYSIS TO DRUG TRANSPORT

    CONCLUSIONS AND PERSPECTIVES

    ACKNOWLEDGMENTS

    Chapter 13: STRUCTURE AND FUNCTION OF OSMOREGULATED ABC TRANSPORTERS

    INTRODUCTION

    STRUCTURAL ANALYSIS OF OSMOREGULATED ABC TRANSPORTERS

    SPECIFICITY OF OSMOREGULATED ABC TRANSPORTERS

    OSMOTIC REGULATION OF EXPRESSION OF GENES ENCODING ABC TRANSPORTERS

    OSMOTIC REGULATION OF ACTIVITY OF ABC TRANSPORTERS

    CHALLENGES AND PERSPECTIVES

    ACKNOWLEDGMENTS

    PART IV: NON-MAMMALIAN EUKARYOTE ABC TRANSPORTERS

    Chapter 14: INVENTORY AND EVOLUTION OF FUNGAL ABC PROTEIN GENES

    INTRODUCTION

    THE INVENTORY AND MOLECULAR ARCHITECTURE OF FUNGAL ABC PROTEINS

    THE PLEIOTROPIC DRUG RESISTANCE (PDR) SUBFAMILY

    THE MULTIDRUG RESISTANCE-RELATED PROTEIN MRP/CFTR SUBFAMILY

    THE ALDP ADRENOLEUKODYSTROPHY PROTEIN SUBFAMILY

    THE MDR SUBFAMILY

    THE NON-TRANSPORTER YEF3/RLI SUBFAMILIES AND NON-CLASSIFIED ABC PROTEINS

    EVOLUTIONARY RELATIONSHIPS OF ABC GENES IN FUNGI

    TRANSCRIPTOMES AND YEAST ABC GENE MRNA PROFILES

    ACKNOWLEDGMENTS

    Chapter 15: FUNGAL ABC PROTEINS IN CLINICAL DRUG RESISTANCE AND CELLULAR DETOXIFICATION

    INTRODUCTION

    PLEIOTROPIC DRUG RESISTANCE ABC TRANSPORTERS IN FUNGI

    GENETIC ANALYSIS AND PHENOTYPIC CHARACTERIZATION

    SUBSTRATE SPECIFICITY AND MECHANISMS OF DRUG RECOGNITION BY FUNGAL ABC PUMPS

    MUTATIONAL ANALYSIS OF YEAST ABC PUMPS AND STRUCTURE–FUNCTION RELATIONSHIPS

    CELLULAR DISTRIBUTION, TRAFFICKING, MEMBRANE LOCALIZATION AND PROTEOLYTIC TURNOVER

    FUNCTIONAL ASSAYS FOR YEAST ABC PUMPS MEDIATING DRUG RESISTANCE

    HETEROLOGOUS EXPRESSION OF EUKARYOTIC ABC PUMPS AND FUNCTIONAL COMPLEMENTATION IN YEAST

    CLINICAL RELEVANCE OF ABC PUMPS FROM FUNGAL PATHOGENS AND THERAPEUTIC STRATEGIES

    REGULATION OF DRUG RESISTANCE GENES WITHIN THE YEAST PDR NETWORK

    THE CROSSTALK BETWEEN PDR AND STRESS RESPONSES

    THE PHYSIOLOGICAL FUNCTIONS OF YEAST ABC PUMPS

    CONCLUSIONS AND PERSPECTIVES

    ACKNOWLEDGMENTS

    Chapter 16: DRUG RESISTANCE MEDIATED BY ABC TRANSPORTERS IN PARASITES OF HUMANS

    INTRODUCTION

    OCCURRENCE OF ABC TRANSPORTERS IN PARASITES

    ROLE OF PARASITIC ABC TRANSPORTERS INCLUDING THEIR INVOLVEMENT IN DRUG RESISTANCE

    CLINICAL IMPLICATIONS AND OUTLOOK

    ACKNOWLEDGMENTS

    Chapter 17: THE PLANT ABC TRANSPORTER SUPERFAMILY: THE FUNCTIONS OF A FEW AND IDENTITIES OF MANY

    INTRODUCTION

    SUBFAMILIES OF ARABIDOPSIS ABC PROTEINS

    FULL-MOLECULE ABC TRANSPORTERS

    HALF-MOLECULE TRANSPORTERS

    ‘SOLUBLE’ ABC PROTEINS

    WHY SO MANY ABC PROTEIN GENES IN ARABIDOPSIS?

    CONCLUDING REMARKS

    ACKNOWLEDGMENTS

    PART V: MAMMALIAN MULTIDRUG RESISTANCE ABC TRANSPORTERS

    Chapter 18: SOLVING THE PROBLEM OF MULTIDRUG RESISTANCE: ABC TRANSPORTERS IN CLINICAL ONCOLOGY

    INTRODUCTION

    ABC TRANSPORTERS WITH POTENTIAL ROLES IN MULTIDRUG RESISTANCE

    P-GLYCOPROTEIN (ABCB1) AS THE FIRST MDR TRANSPORTER TARGETED IN CLINICAL TRIALS

    DETERMINING THE EXPRESSION OF DRUG TRANSPORTERS IN CANCER

    EXPRESSION OF ABC TRANSPORTERS IN SELECTED MALIGNANCIES

    P-GLYCOPROTEIN INHIBITORS AND PHARMACOKINETIC INTERACTIONS

    REVERSAL OF DRUG RESISTANCE MEDIATED BY ABC TRANSPORTERS

    PREVENTION OF DRUG RESISTANCE

    CONCLUSION

    Chapter 19: MULTIDRUG RESISTANCE PROTEIN 1 (ABCC1)

    INTRODUCTION

    PROPERTIES OF MRP1

    CLINICAL RELEVANCE OF MRP1

    Chapter 20: MRP2, THE APICAL EXPORT PUMP FOR ANIONIC CONJUGATES

    INTRODUCTION

    MOLECULAR CHARACTERIZATION OF THE APICAL CONJUGATE EXPORT PUMP MRP2

    TISSUE DISTRIBUTION AND LOCALIZATION OF MRP2 IN POLARIZED CELLS

    FUNCTIONAL ANALYSIS AND SUBSTRATE SPECIFICITY OF MRP2

    DETOXIFICATION AND DRUG RESISTANCE CONFERRED BY MRP2

    MUTATIONS IN THE MRP2 GENE

    REGULATION OF MRP2 GENE EXPRESSION

    CONCLUSIONS AND PERSPECTIVES

    ACKNOWLEDGMENTS

    Chapter 21: THE MULTIDRUG RESISTANCE PROTEINS 3–7

    INTRODUCTION

    MRP3

    MRP4

    MRP5

    MRP6

    MRP7

    ACKNOWLEDGMENTS

    PART VI: ABC TRANSPORTERS, PHYSIOLOGICAL ROLES AND HUMAN DISEASE

    Chapter 22: LIPID TRANSPORT BY ABC TRANSPORTERS

    INTRODUCTION

    THE MDR1 (ABCB1) P-GLYCOPROTEIN AND ITS ROLE IN TRANSPORTING PHYSIOLOGICAL LIPIDS

    TRANSPORT OF LIPID ANALOGUES BY ABC TRANSPORTERS

    THE PC TRANSLOCATOR (MDR3, MDR2, ABCB4)

    STEROL TRANSPORT BY ABC TRANSPORTERS

    ACKNOWLEDGMENTS

    Chapter 23: ROLE OF ABCA1 IN CELL TURNOVER AND LIPID HOMEOSTASIS

    STRUCTURAL TRAITS OF ABCA1 AND RELATED TRANSPORTERS

    THE IMPACT OF ABCA1 ON PHYSIOLOGICAL FUNCTIONS

    ACKNOWLEDGMENTS

    Chapter 24: PEROXISOMAL ABC TRANSPORTERS

    INTRODUCTION

    OVERVIEW OF PEROXISOME BIOLOGY

    PEROXISOME ABC TRANSPORTERS

    ACKNOWLEDGMENTS

    Chapter 25: ABC TRANSPORTERS IN MITOCHONDRIA

    INTRODUCTION

    MITOCHONDRIAL ABC TRANSPORTERS IN S. CEREVISIAE

    MITOCHONDRIAL ABC TRANSPORTERS IN MAMMALS

    MITOCHONDRIAL ABC TRANSPORTERS IN PLANTS

    FUTURE DIRECTIONS

    ACKNOWLEDGMENTS

    Chapter 26: THE TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING (TAP): A PEPTIDE TRANSPORT AND LOADING COMPLEX ESSENTIAL FOR CELLULAR IMMUNE RESPONSE

    OVERVIEW OF THE MHC CLASS I ANTIGEN PROCESSING

    THE TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING, TAP (ABCB2/ABCB3)

    TAP AS A CENTRAL PART OF A MACROMOLECULAR PEPTIDE TRANSPORT AND CHAPERONE COMPLEX

    VIRAL STRATEGIES OF IMMUNE EVASION

    TUMOR ESCAPE STRATEGIES

    CONCLUSIONS

    Chapter 27: THE SULFONYLUREA RECEPTOR: AN ABCC TRANSPORTER THAT ACTS AS AN ION CHANNEL REGULATOR

    INTRODUCTION

    PHYSIOLOGICAL ROLE

    MOLECULAR PROPERTIES

    REGULATION BY NUCLEOTIDES

    METABOLIC REGULATION OF THE KATP CHANNEL

    EFFECTS OF OTHER KATP CHANNEL REGULATORS

    PHARMACOLOGY

    CONCLUSION AND PERSPECTIVES

    GLOSSARY

    ACKNOWLEDGMENTS

    Chapter 28: ABC TRANSPORTERS AND HUMAN EYE DISEASE

    INTRODUCTION

    ABCA4 IN RETINAL DYSTROPHIES

    ABCA4 IN AGE-RELATED MACULAR DEGENERATION (AMD)

    FUNCTIONAL STUDIES OF ABCA4

    ABCC6 AND PSEUDOXANTHOMA ELASTICUM

    PERSPECTIVES

    ACKNOWLEDGMENTS

    Chapter 29: THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (ABCC7)

    CFTR MUTATION CAUSES CYSTIC FIBROSIS

    CFTR STRUCTURE

    CFTR IS AN EPITHELIAL CHLORIDE CHANNEL

    THE CFTR CHANNEL PORE

    SER/THR PHOSPHORYLATION ACTIVATES THE CHANNEL

    CFTR BINDS AND HYDROLYZES ATP

    REGULATION OF CHANNEL GATING BY PURINE NUCLEOTIDES

    CFTR MATURATION AND TRAFFICKING IN THE SECRETORY PATHWAY

    Chapter 30: ABC PROTEINS, THE FASCINATION, THE POLITICS, THE POTENTIAL FOR APPLICATIONS FOR IMPROVING HUMAN HEALTH

    THE FASCINATION

    THE POLITICS

    DIFFICULTIES, REALITIES AND PROSPECTS FOR APPLICATIONS

    PREVENTION AND TREATMENTS OF DISEASE: THE MOLECULAR FUTURE

    PERSPECTIVES

    Index

Product details

  • No. of pages: 530
  • Language: English
  • Copyright: © Academic Press 2015
  • Published: January 7, 2003
  • Imprint: Academic Press
  • eBook ISBN: 9780080481876

About the Editors

I Barry Holland

Affiliations and Expertise

Universite Paris-Sud XI, France

Susan Cole

Affiliations and Expertise

Cancer Care Ontario, Queen's University, Ontario, Canada

Karl Kuchler

Affiliations and Expertise

Department of Molecular Genetics, University and Biocenter Vienna, Vienna, Austria

Christopher Higgins

Affiliations and Expertise

MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London UK

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  • amera m. Fri Nov 09 2018

    ABC Proteins

    ti's very good and usufull book