A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics

A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent.

• Offers advanced students, as well as new researchers, an overview of the principles of stem cell therapy
• Discusses a wide array of pressing clinical issues with stem cell-based therapies so that new ideas in the laboratory can be efficiently translated to the clinic through better designed clinical trials
• Helps clarify current regulatory mechanisms so that the safe use of stem cells for treating a variety of diseases can move forward
• Fosters cross-disciplinary dialogue between research scientists and physicians to accelerate the safe implementation of efficacious cell therapies

Basic science and clinial researchers, postdocs, fellows, advanced students, and residents focused on the development of stem cell/cell-based therapies

Part 1 Principles and Concepts

1. What Can We Learn From This Book?

Travis J. Block, David D. Dean and Xiao-Dong Chen

2. Features of Mesenchymal Stem Cells

Stan Gronthos

3. Maintenance and Culture of  MSCs

Milos Marinkovic, David D. Dean and Xiao-Dong Chen

4. Manufacturing Mesenchymal Stromal Cell Banks

Jamie Hoover and Patrick J. Hanley

Part 2 Promises and Challenges of MSC-Based Therapies

5. Mesenchymal Stem Cell-Based Therapy of Osteoarthritis: Current Clinical Developments and Future Therapeutic Strategies

Maxime Ruiz, Marie Maumus, Christian Jorgensen and Daniele Noel

6. Mesenchymal Stem Cell Therapy in Graft Versus Host Disease

Shivaprasad Manjappa, Rizwan Romee and Armin Rashidi

7. Systemic Lupus Erythematosus

Dandan Wang and Lingyun Sun

8. Mesenchymal Stem Cell-Based Therapies for Repair and Regeneration of Skin Wounds

Shanmugasundaram Natesan, Randolph Stone, Rodney K. Chan and Robert J. Christy

9. Myocardial Infarction

Natalia Rozwadowska and Maciej Kurpisz

10. Bone Marrow Mesenchymal Stem Cells as a New Therapeutic Approach for Diabetes Mellitus

Joseph Kim, John Z. Q. Luo and Luguang Luo

11. Mesenchymal Stem Cell-Based Therapy for Chronic Kidney Disease

Maria V. Irazabal, LaTonya J. Hickson and Alfonso Eirin

12. Promises and Challenges of MSC-Based Therapies: Parkinson Disease and Parkinsonism

Ashley Aaroe and Claire Henchcliffe

13. Spinal Cord Injury

K. A. Ruppert, S. D. Olson and C. S. Cox

14. Stem Cell-Based Restoration of Salivary Gland Function

Olivia N. Tran, Hanzhou Wang, David D. Dean, Xiao-Dong Chen and Chih-Ko Yeh

15. Tooth and Dental Pulp Regeneration

Bei Li, Chen Xi and Yan Jin

Part 3: Future Perspectives

16. MSCs as Biological Drugs

Thekkeparambil Chandrabose Srijaya, Sandhya Sriram, Noor Hayaty Abu Kasim and Shigeki Sugii

17. Mesenchymal Stem Cell-Derived Products for Tissue Repair and Regeneration

Anand Srinivasan, Michelle Lynn Fults, Peter Supronowicz, Roberto Esquivel and Rogelio Zamilpa

18. Use of MSCs in Antiaging Strategies

Travis J. Block, David D. Dean and Xiao-Dong Chen

19. Regulatory Developments for Nonhematopoietic Stem Cell Therapeutics: Perspectives From the EU, the USA, Japan, China, India, Argentina, and Brazil

Achim Rosemann, Gabriela Bortz and Federico Vasen