A History of Transplantation Immunology

A History of Transplantation Immunology

1st Edition - November 18, 1996

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  • Author: Leslie Brent
  • eBook ISBN: 9780080533995

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Those entering the field of transplantation are frequently unaware of the topics historical roots and even of the background on which modern discoveries in tolerance, histocompabatibility antigens, and xenotransplantation are based. A History of Transplantation Immunology is an account, written by one of the founding fathers of the field, of how tissue and organ transplantation has become one of the most successful branches of late 20th century medicine. The book helps place the work of contemporary scientists into its proper context and makes fascinating reading for immunologists in all stages of their career.

Key Features

  • Describes landmarks in immunology and places them in historical context
  • Beautifully written by one of the founding fathers of the field
  • Portrays the surprising history of events in a colorful and readable manner
  • Contains biographical sketches of some of the pioneers
  • Illustrates the development of key ideas in immunology--tolerance, graft rejection, and transplantation
  • Foreword by Ray Owen


Immunologists of all levels, surgeons, physicians, pathologists, geneticists, cell biologists, cancer biologists, and students of immunology

Table of Contents

  • R.D. Owen, Foreword.
    A Note on Nomenclature.
    Landmarks in Immunology.
    The Immunological Basis of Allograft Rejection.
    Blood Transfusion.
    Blood Groups and Hemolytic Disease of the Newborn.
    Immunogenetics: Histocompatibility Antigens--Structure and Function.
    Fetally and Neonatally Induced Immunological Tolerance.
    Immunoregulation--The Search for the Holy Grail.
    Clinical Aspects and Immunosuppression.
    Graft-versus-Host Disease and Bone Marrow Transplantation.
    The Mammalian Fetus: Natures (Almost) Perfect Allograft.
    The Interaction Between Immunology, Transplantation, Surgery, and Other Matters.
    Name Index.
    Subject Index.

Product details

  • No. of pages: 482
  • Language: English
  • Copyright: © Academic Press 1996
  • Published: November 18, 1996
  • Imprint: Academic Press
  • eBook ISBN: 9780080533995

About the Author

Leslie Brent

Leslie Brent was awarded the 1994 Peter Medawar Prize by the Transplantation Society at its 15th World Congress. Dr. Brent was also part of Sir Peter Medawars group that was awarded the Nobel Prize in 1960 for research on immunological tolerance. He has spent his professional life studying all aspects of transplantation immunology including tolerance, graft-versus-host disease and mechanisms, rejection,and fetal immunology.

Affiliations and Expertise

St. Marys Hospital Transplant Unit, Paddington, London, U.K.

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