A History of Modern Immunology - 1st Edition - ISBN: 9780124169746, 9780124201088

A History of Modern Immunology

1st Edition

The Path Toward Understanding

Authors: Zoltan Nagy
eBook ISBN: 9780124201088
Hardcover ISBN: 9780124169746
Imprint: Academic Press
Published Date: 1st November 2013
Page Count: 356
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A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists.

This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries.

Key Features

  • Contains the history of major breakthroughs in immunology featured with authenticity and insider details
  • Gives an insight into personal aspects of the players in the history of immunology
  • Enables the reader to recognize and select data of heuristic value which elucidate important facets of the immune system
  • Provides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune system
  • Gives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author


research immunologists, immunology students from Master to PhD, secondary audience comprises clinical immunologists to help them connect basic immunology, research managers in pharma and biotech industry.

Table of Contents


Introductory Words About Science, Scientists, and Immunology


Part I: Pre-history with Far-reaching Consequences

Chapter 1. The Immunological Revolution


1.1 The Clonal Selection Theory

1.2 The Birth of B and T Lymphocytes

1.3 T-B Cell Collaboration

1.4 The Structure of Immunoglobulins

1.5 Allergy: from Disease Symptoms to IgE


Part II: The History



Chapter 2. A Very Special Location: The Basel Institute for Immunology



Chapter 3. Immunological Specificity



Chapter 4. Monoclonal Antibodies: The Final Proof for Clonal Selection


4.1 Discovery

4.2 Immunology Goes Business

4.3 The Technology Avalanche: Antibody Engineering


Chapter 5. The First Victory of Molecular Biology: Mechanisms of the Generation of Antibody Diversity


5.1 Theoretical Treatment of the Problem

5.2 The Experimental Solution

5.3 What did We Learn from the Mechanisms of GOD?

5.4 A Baroque Embellishment of Antibody Diversity: the Idiotype Network


Chapter 6. The Major Histocompatibility Complex


6.1 MHC Class I

6.2 MHC Class II

6.3 Sorting Out the Genetics of MHC


Chapter 7. Antigen Processing and Presentation


7.1 The Rules of Peptide Binding to MHC Molecules

7.2 The Most Revealing Crystallographic Study in the History of Immunology: the Three-Dimensional Structure of MHC Molecules

7.3 Antigen Processing and Loading Pathways

7.4 The Case for a Specialized Antigen-Presenting Cell

7.5 Antigen Processing and Presentation: Phenomena that Beg for a Concept


Chapter 8. The Intricate Behavior of T Cells


8.1 Major Histocompatibility Complex Restriction of T-Cell Recognition

8.2 Chase for the Antigen Receptor of T Cells

8.3 T-Cell Recognition: From Facts Toward Understanding

8.4 Thymus and the T-Cell Repertoire

8.5 Alloreactivity: the Continuing Puzzle

8.6 Functional Subclasses of T cells

8.7 Cell Adhesion, Costimulation, Co-Inhibition


Chapter 9. Acquired Immunological Tolerance


9.1 Discovery

9.2 The Era of Theories

9.3 The Era of Mechanistic Studies

9.4 Can Self Tolerance be Understood?


Chapter 10. Autoimmunity


10.1 Genetic Factors Predisposing to Autoimmune Disease

10.2 How is Autoimmunity Initiated?

10.3 Some Aspects of Pathogenesis

10.4 Approaches to Immunotherapy

10.5 What is Needed for Better Understanding of Autoimmunity?


Concluding Remarks



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© Academic Press 2014
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About the Author

Zoltan Nagy

Zoltan Nagy

Dr. Nagy, a world-leading immunologist, previously held positions as Scientific Member of the Basel Institute of Immunology, Deputy Director of the Max-Planck-Institute for Biology in Tuebingen, Project Leader in Preclinical Research at Novartis in Basel and most recently as Department Head of Immunology at Hoffmann-La Roche in Nutley. Dr. Nagy's research into the major histocompatibility complex has resulted in over 140 papers in peer-reviewed journals. He's actively contributed to immunology research from 1970 to 2006 and is an author of over 150 research publications (mostly in high impact international journals). He's directly contributed to the majority of sub disciplines, the history of which is described in this book. He personally knows almost all prominent scientists in immunology including 8 Nobel Laureates. This background put him uniquely into the position of writing up the history of immunology in the last third of the twentieth century with authenticity and insider details.

He's significantly contributed to the genetics of the major histocompatibility complex (MHC), to the MHC-association of autoimmune diseases, and to different aspects of T cell biology. Formerly, he was a member of the Basel Institute for Immunology, deputy director at the Department of Immunogenetics, Max-Planck-Institute of Biology, Tübingen, Germany, head of the Immunology Department, Hoffmann La Roche Inc., Nutley, NJ, USA, and head of research at GPC-Biotech Inc., Munich, Germany. Also is a former editorial board member of “Immunogenetics”, and “Human Immunology”.

Affiliations and Expertise

DVM, PhD, Emeritus Professor of Immunology


"...lively in part because, at its core, it recognizes the human and subjective side of doing science...constitutes an enthusiastic and warm account of immunological progress...The human engagement in his account makes the scientific issues more understandable, their significance more apparent and fascinating." --Journal of the History of Biology, A History of Modern Immunology

"…introduces each of the ten sections with some level of background or historical context, beginning with the discovery of DNA rearrangement in the generation of antibody diversity and finishing with the concepts of immune tolerance and autoimmunity…also explains the significance of specific experiments. Summing Up: Recommended." --Choice, July 2014

"An immunology industry insider surveys the recent history of the branch of life sciences that studies immune system functions and summarizes major discoveries resulting from immunological research conducted since 1970. The chronicle describes the clarification of immunoglobulin structure, the interaction of antibody with antigen, the mechanisms for generation of antibody diversity, the T-cell antigen receptor, and the nature of its ligand.." --ProtoView.com, January 2014

Ratings and Reviews