Description

A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights.

The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells.

Key Features

  • Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles
  • Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology
  • Presents concepts such as the division of lymphocytes into functionally different populations in their historical context
  • Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells

Readership

graduate and undergraduate students entering the fields of immunology, molecular biology and other biomedical disciplines, their instructors and mentors. Researchers, practitioners and those interested in the evolution of ideas and scientific methods

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Dedication
  • Copyright
  • Foreword
  • Glossary of Historical Terms
  • Chapter 1. Innate Host Defense Mechanisms and Adaptive Immune Responses
    • Introduction
    • Innate Defense Mechanisms
    • Adaptive Immune Responses
    • Conclusion
  • Chapter 2. Hallmarks of the Adaptive Immune Responses
    • Introduction
    • Immunologic Specificity
    • Self–Non-Self-Discrimination
    • Immunologic Memory
    • Conclusion
  • Chapter 3. Two Effector Mechanisms of the Adaptive Immune Response
    • Introduction
    • Antibody
    • Cell-Mediated Immunity
    • Conclusion
  • Chapter 4. The Small Lymphocyte Is the Antigen Reactive Cell
    • Introduction
    • The Small Lymphocyte
    • Passive Transfer Experiments
    • Migratory Pathways of Small Lymphocytes
    • Depletion Experiments
    • Immunocompetence of Thoracic Duct Lymphocytes
    • Morphological Changes of Activated Small Lymphocytes
    • Conclusion
  • <

Details

No. of pages:
394
Language:
English
Copyright:
© 2016
Published:
Imprint:
Elsevier
Print ISBN:
9780123983817
Electronic ISBN:
9780123983756