A Comprehensive Guide to Hidradenitis Suppurativa

A Comprehensive Guide to Hidradenitis Suppurativa

1st Edition - October 20, 2021

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  • Authors: Vivian Shi, Jennifer Hsiao, Michelle Lowes, Iltefat Hamzavi
  • eBook ISBN: 9780323777254
  • Hardcover ISBN: 9780323777247

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Description

Despite being a relatively straightforward clinical diagnosis, recognition of hidradenitis suppurativa (HS) is highly variable, and clinical management is challenging and complex. Written by the world’s leading experts in HS, A Comprehensive Guide to Hidradenitis Suppurativa brings together up-to-date scientific evidence on the diagnosis, patho-mechanisms, comorbidities, and multi-faceted medical and surgical interventions for this debilitating condition—in one convenient reference.

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Foreword
  • Contributors
  • Video Contents
  • Section 1: Introduction to Hidradenitis Suppurativa
  • 1: Historical Perspective on Hidradenitis Suppurativa
  • Abstract
  • Introduction
  • Historic Figures in Hidradenitis Suppurativa
  • Terminology
  • Uncovering Hidradenitis Suppurativa Pathogenesis Studies Throughout History
  • The Birth of Hidradenitis Suppurativa Staging Systems
  • A Historical Note on Hidradenitis Suppurativa Treatment
  • Lessons From the Past
  • Conclusion
  • Acknowledgments
  • References
  • 2: Hidradenitis Suppurativa Epidemiology
  • Abstract
  • Introduction
  • Hidradenitis Suppurativa Epidemiology
  • Conclusion
  • References
  • 3: Clinical Manifestation and Phenotypes of Hidradenitis Suppurativa
  • Abstract
  • Clinical Manifestation
  • Current Phenotypic Classifications
  • References
  • 4: Hidradenitis Suppurativa Differential Diagnosis and Mimickers
  • Abstract
  • Introduction
  • Infections
  • Inflammatory Disorders
  • Miscellaneous
  • Summary
  • References
  • 5: Histopathology of the Pilosebaceous Unit and Interstitium of Hidradenitis Suppurativa
  • Abstract
  • Introduction
  • Cutaneous Structure and Cellular Composition in Healthy White and African American Skin
  • The Pilosebaceous Unit in Healthy White and African American Skin
  • Histological Changes in HS in Skin Structures and Across the Disease Spectrum
  • Conclusions
  • References
  • 6: Imaging Techniques in Hidradenitis Suppurativa and Comorbidities
  • Abstract
  • Introduction
  • Basic Physics Concepts of Imaging Techniques
  • Imaging of Hidradenitis Suppurativa
  • Imaging of Hidradenitis Suppurativa Related Diseases
  • Imaging of Comorbidities of Hidradenitis Suppurativa
  • Conclusion
  • References
  • 7: Clinical Evaluation
  • Abstract
  • Overview of Patient Population with HS Prior to Initiating Therapy
  • Obtaining History Related to HS Onset and Family History
  • The Physical Exam
  • Hidradenitis Suppurativa Disease Assessment
  • Other Important Considerations Regarding Therapeutic Choices
  • Impact of Disease on Patient’s Quality of Life
  • Determining Management Options
  • Patient Follow-Up and Lab Monitoring
  • Conclusion
  • References
  • 8: Comorbidities and Systemic Associations
  • Abstract
  • Introduction
  • Associated Inflammatory Skin Diseases
  • Associated Disorders of Follicular Occlusion
  • Associated Cardiovascular Disorders
  • Associated Metabolic Disorders
  • Associated Endocrine Diseases
  • Associated Gastrointestinal Diseases
  • Associated Musculoskeletal Diseases
  • Associated Psychiatric Diseases
  • Associated Genetic Diseases
  • Associated Inflammatory Syndromes
  • Emerging Comorbidities
  • Conclusion
  • References
  • 9: Disease Complications
  • Abstract
  • Introduction
  • Cutaneous Complications
  • Systemic Complications
  • Summary
  • References
  • Section 2: Pathogenesis
  • 10: Follicular Occlusion and Inflammation
  • Abstract
  • Introduction
  • The Evolving Pathogenic Paradigm(s) of Hidradenitis Suppurativa
  • The Problem(s) with Animal and Ex-Vivo Models in Hidradenitis Suppurativa
  • Follicular Occlusion: Comedones are Clinically and Experimentally a Product of Inflammation, Rather Than a Cause
  • Skin Fold Occlusion is Associated with Microbiome Alterations and Subsequent Pro-Inflammatory Keratinocyte Responses
  • Genetic Variants in HS May Act via EGFR-Associated Pathways Linking Follicles, Th17 Mediated Inflammation, and Drug-Induced Disease
  • Disease Initiation is Associated with Systemic Subclinical Inflammation and Dysregulated Infundibular Keratinocytes
  • Inflammation in Hidradenitis Suppurativa: Evidence from Existing Studies
  • TH17 Feed-Forward Inflammation is Prominent in Established Disease
  • The Role of B Cells, Despite their Dominance, Remains Unclear
  • The Evidence and Proposed Mechanisms for Follicular Rupture
  • Dermal Tunnels are Active Inflammatory Organs
  • The Development of Dermal Tunnels is Orchestrated by Dermal Inflammation
  • Conclusions
  • References
  • 11: Microbiota Perturbations in Hidradenitis Suppurativa
  • Abstract
  • Introduction
  • Role of Bacteria in Hidradenitis Suppurativa Biology
  • Bacteriology of Hidradenitis Suppurativa
  • Biofilm in Hidradenitis Suppurativa
  • Skin Microbiota Alterations in Hidradenitis Suppurativa
  • Gut Microbiome Alterations in Hidradenitis Suppurativa
  • Relevance to Therapy
  • Conclusion and Future Directions
  • References
  • 12: Genetics and Epigenetics of Hidradenitis Suppurativa
  • Abstract
  • Introduction
  • Methods
  • Family-Based Linkage Analysis
  • Genome Wide Association Studies
  • γ-Secretase Target Candidate Gene Studies
  • Other Target Candidate Gene Studies
  • Genetic Studies in Syndromic Hidradenitis Suppurativa
  • Epigenetic Studies
  • Discussion
  • Conclusion
  • References
  • Section 3: Clinician’s Corner
  • 13: Disease Evaluation and Outcome Measures
  • Abstract
  • Introduction
  • Characteristics of Well-Designed Outcome Measures
  • The Hidradenitis Suppurativa Core Outcomes Set International Collaboration (HISTORIC): Addressing Current Challenges in Outcome Measure Development and Utilization
  • Current Outcome Measures for Hidradenitis Suppurativa
  • Conclusions and Future Directions
  • References
  • 14: Overview and Comparison of Hidradenitis Suppurativa Management Guidelines
  • Abstract
  • Introduction
  • General Guideline Comparison
  • Detailed Comparison by HS Treatment Modality
  • Conclusion
  • References
  • 15: Topical Therapeutics
  • Abstract
  • Introduction
  • Antibiotics
  • Antiseptics
  • Keratolytics
  • Bathing Additives
  • Complementary Therapies
  • Summary
  • References
  • 16: Systemic Antibiotics in Hidradenitis Suppurativa
  • Abstract
  • Introduction
  • Rationale for the Use of Antibiotics in Hidradenitis Suppurativa
  • Antibiotics in Hidradenitis Suppurativa: Literature Review
  • Approach to Antibiotic Treatments in Hidradenitis Suppurativa
  • Conclusion
  • References
  • 17: Non-Antibiotic and Non-Biologic Systemic Therapeutics
  • Abstract
  • Introduction
  • Hyperandrogenism and Hidradenitis Suppurativa
  • Insulin Resistance and Obesity
  • Immune System Regulation
  • Conclusions
  • References
  • 18: Targeted Therapeutics: Biologics, Small Molecules
  • Abstract
  • Introduction
  • Tumor Necrosis Factor Inhibition
  • Other Biologic Therapies
  • Tofacitinib (JAK Inhibitor)
  • Special Circumstances in the Use of Biologic Therapy for Hidradenitis Suppurativa
  • Use of Biologic Therapies in the Setting of Malignancy
  • Conclusion
  • References
  • 19: Pain and Itch Control
  • Abstract
  • Introduction
  • Pain in Hidradenitis Suppurativa
  • Pruritus in Hidradenitis Suppurativa
  • Conclusion
  • References
  • 20: Dressings and Wound Care Supplies for Hidradenitis Suppurativa
  • Abstract
  • Introduction to Wound Care in Hidradenitis Suppurativa
  • Dressings for Typical Hidradenitis Suppurativa Lesions
  • Summary
  • References
  • 21: Quality of Life
  • Abstract
  • Introduction
  • Quality of Life Comparisons to Other Dermatologic Diseases
  • Physical Symptoms and Disease Severity
  • Mental Health
  • Substance Use Disorders
  • Sexual Health
  • Daily and Work Functions
  • Healthcare Costs Related to Hidradenitis Suppurativa
  • Conclusion
  • References
  • 22: Office-Based Non-Excision Procedures
  • Abstract
  • Introduction
  • General Approach to Procedures
  • Preoperative Anesthesia/Anxiolytics
  • Intralesional Triamcinolone
  • Incision and Drainage
  • Deroofing
  • Radiation
  • Chemical Peels
  • Neurotoxins
  • Postoperative Considerations
  • Conclusion
  • References
  • 23: Operative Techniques for Hidradenitis Suppurativa
  • Abstract
  • History of Surgery in Hidradenitis Suppurativa
  • Setting Goals for Surgery
  • Operative Techniques
  • Options for Wound Closure and Reconstruction in Hidradenitis Suppurativa
  • How to Optimize the Surgical Patient
  • Adjuncts to Surgical Management (Combined Medical and Surgical Management)
  • Role for Interdisciplinary Care and Collaboration
  • References
  • 24: Office-Based Excision for Hidradenitis Suppurativa: A Surgeon’s Decades-Long Experience
  • Abstract
  • Introduction
  • Historical Perspective
  • Surgical Approaches
  • Cure Rates With Hidradenitis Suppurativa Excision
  • My Technique
  • Surgical Challenges
  • Reimbursement
  • Conclusion
  • References
  • 25: Laser and Light Treatments for Hidradenitis Suppurativa
  • Abstract
  • Introduction
  • Carbon Dioxide Laser
  • Neodymium-doped Yttrium Aluminum Garnet Laser
  • Alexandrite Laser
  • Diode Laser
  • Photodynamic Therapy
  • Radiofrequency
  • Intense Pulse Light
  • External Beam Radiation
  • Conclusion
  • References
  • 26: Hidradenitis Suppurativa—Other Procedural Treatments
  • Abstract
  • Introduction
  • Procedural Options
  • Summary
  • References
  • 27: Lifestyle Modifications
  • Abstract
  • Introduction
  • Diet
  • Weight and Hidradenitis Suppurativa
  • Cigarette Smoking and Hidradenitis Suppurativa
  • Physical Irritants and Hidradenitis Suppurativa
  • Exercise
  • Work and Hidradenitis Suppurativa
  • Stress Management
  • Conclusion
  • References
  • 28: Complementary and Alternative Medicine
  • Abstract
  • Introduction
  • Complementary and Alternative Medicine Methods
  • Conclusion
  • References
  • Section 4: Special Populations
  • 29: Pediatric Hidradenitis Suppurativa
  • Abstract
  • Introduction
  • Pathogenesis
  • Epidemiology
  • Clinical Features
  • Treatment
  • Conclusion
  • References
  • 30: Skin of Color
  • Abstract
  • Prevalence of Hidradenitis Suppurativa in Skin of Color Individuals
  • Skin of Color Representation in Hidradenitis Suppurativa Clinical Trials
  • Light/Laser and Other Treatment Considerations
  • Genetics and Anatomy
  • Keloids
  • Comorbidities
  • Access to Adequate and Empathetic Care
  • Conclusion
  • References
  • 31: Hidradenitis Suppurativa in Women
  • Abstract
  • Introduction
  • Menses
  • Fertility
  • Pregnancy
  • Lactation
  • Menopause
  • Women’s General Preventive Health Care and Lifestyle Considerations
  • Conclusion
  • References
  • Section 5: Combined Approach
  • 32: Building a Multidisciplinary Hidradenitis Suppurativa Clinic
  • Abstract
  • Introduction
  • Treatment Algorithm
  • Domains of Expertise
  • Quality Improvement
  • Core Specialties for Referrals and Collaboration
  • Conclusion
  • References
  • 33: Support Groups in Hidradenitis Suppurativa—Building a Community
  • Abstract
  • Introduction
  • How to Get Started
  • Participant Interactions
  • Use of Social Media in Support Groups
  • Attendance
  • Mental Health
  • Community Perception and Transparency
  • Participant Perspectives
  • Conclusion
  • References
  • Section 6: On the Horizon
  • 34: Pipeline Therapeutics
  • Abstract
  • Introduction
  • Neutrophils and Complement
  • Cytokines
  • JAK-STAT Signaling Pathway
  • Other Medications
  • Surgical and Procedural Treatments
  • Wound Care
  • Complementary and Alternative Medicine
  • Summary
  • References
  • 35: The Future
  • Abstract
  • Introduction
  • Major Gaps to Address Now for Optimal Care of HS Patients in the Future
  • The Journey From Gaps to Goals
  • Programs & Initiatives to Get Us There
  • Conclusion
  • References
  • Index

Product details

  • No. of pages: 368
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: October 20, 2021
  • Imprint: Elsevier
  • eBook ISBN: 9780323777254
  • Hardcover ISBN: 9780323777247

About the Authors

Vivian Shi

Dr. Vivian Shi is the Director of Clinical Trials and the Eczema Specialty Clinic at the University of Arkansas for Medical Sciences. Her research and clinical interests are in complex inflammatory skin conditions, skin barrier repair, transepidermal drug delivery, and integrative dermatology. She was an integral part of the team of researchers characterizing the pathophysiology of atopic dermatitis using a transgenic interleukin-4 mouse model of atopic dermatitis. She has published over 150 peer-reviewed articles, and is on the speaker’s bureau and the steering committee for the U.S. National Eczema Association and is a faculty member of the International Eczema Council. She has served as the principal investigator for numerous industry-sponsored and investigator-initiated clinical and translational studies in eczematous conditions. She regularly speaks in national and international conferences on atopic dermatitis and inflammatory skin conditions. Additionally, she is the recipient of the several prestigious awards and grants.

Affiliations and Expertise

Associate Professor, Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, U.S.A.

Jennifer Hsiao

Affiliations and Expertise

Assistant Clinical Professor of Dermatology, Director, Hidradenitis Suppurativa Specialty Clinic, University of California, Los Angeles, California

Michelle Lowes

Affiliations and Expertise

Associate Professor of Clinical Investigation, The Laboratory for Investigative Dermatology, Rockefeller University, New York, New York

Iltefat Hamzavi

Affiliations and Expertise

Henry Ford Hospital, Clinical Associate Professor, Department of Dermatology, Wayne State University SOM; President, HS Foundation, Detroit, Michigan

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