Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries.
Increases the knowledge of anti-inflammatory activities of natural products and their mechanism of action
Provides a new perspective and forward-thinking ideas to researchers, the scientific community and industry
Intensifies the understanding of synergistic action of biologically active naturally occurring molecules and their biological activities against inflammation
Graduate students, academics and professionals in the fields of pharmaceutical and medical sciences and specialists from natural products-related industry
Table of Contents
1. Inflammation - Symptoms, Reactions and Biochemistry 2. Molecular and genetic inflammation networks in major human diseases 3. Natural products in inflammation: The emerging trends and prospective goals 4. Natural products as modulator of signaling in inflammation 5. Natural products with anti-inflammatory activities against autoimmune myocarditis 6. Multi-target approach for natural products in inflammation 7. Anti-inflammatory activity of natural dietary flavonoids 8. Anti-inflammatory effects of turmeric and ginger 9. Potential anti-inflammatory natural products from marine algae 10. Natural product derived drugs for the treatment of inflammatory bowel diseases 11. Smart drug delivery systems of natural products for inflammation: from fundamentals to the clinic 12. Systems pharmacology and molecular docking strategies prioritize natural molecules as anti-inflammatory agents 13. Formulations, supplements and diets for anti-inflammation 14. Values of natural products to future anti-inflammatory pharmaceutical discovery 15. Metabolomic study of natural products in toxicity evaluation and toxicology biomarker identification
Dr. Sreeraj Gopi is Chief Scientist at Plant Lipids Pvt Ltd. and Chief Scientific Officer at Aurea Biolabs Pvt Ltd., and has also served as an adjunct professor at universities including Stockholm University, Sweden, Siberian Federal University, Russia, and Mahatma Gandhi University, India. He completed his doctorate in organic chemistry and nanotechnology, working in the area of natural products, isolation, and biological activities. He has published more than 75 international articles and filed more than 70 patents, including in the US and Europe. In his work at Plant Lipids, he has developed many innovative products and technologies, and is responsible for driving the research team to excellence, as well as the generation, implementation of new projects, and the presentation of scientific seminars to various customers.
Dr. Augustine Amalraj is currently working as an Assistant Manager in the Department of Research and Development at Plant Lipids Private Limited, Cochin, India. He obtained his Doctoral degree in Chemistry from Gandhigram Rural Institute – Deemed University, Gandhigram, Tamil Nadu, India. His research interests are in applied chemistry, food chemistry, natural product chemistry, environmental chemistry, chemosensors, and polymer and nanocomposite materials. He has published more than 40 research articles in international journals, as well as 6 book chapters.
Affiliations and Expertise
Aurea Biolabs Private Ltd, India
Prof. Ajaikumar Kunnumakkara, is a faculty member in the Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India. He is also an Honorary Chair Professor in Nanoscience and Nanotechnology. He is the principal investigator of Unit of Excellence in cancer drug discovery (DBT, Govt. of India) and the coordinator of DBT (India) - AIST (Japan) International Laboratory for Advanced Biomedicine. He earned his doctorate in 2006 from Amala Cancer Research Center, Thrissur, affiliated with University of Calicut, Kerala, India. Dr. Kunnumakkara did postdoctoral work at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA (2005–2008) and the National Cancer Institute of National Institutes of Health (2008–2010) where he was subsequently employed as an NIH Scientist until 2012. Dr. Kunnumakkara has also edited four monographs. He is an elected Fellow of Royal Society of Medicine, UK as well as belonging to many other esteemed institutions.
Affiliations and Expertise
Indian Institute of Technology Guwahati, India
Prof. Sabu Thomas, an outstanding Alumnus of IIT, Kharagpur, is one of India’s most renowned scientists in the area of Polymers. After completing his Ph.D. from IIT Kharagpur (1984-1987), he joined MG University as a Lecturer in 1997 and later became its Vice Chancellor. He has taken up a large number of visiting assignments abroad. Under his leadership, the University has been ranked 713th by TIMES, 30th in NIRF and the best University inKerala. He has supervised 120 Ph.D. students, authored 1,300 publications and edited 150 books earning him a H-index of 112 and 60,000 citations. He has received Honoris Causa degrees from Russia and France and obtained grants amounting to Rs. 30 crores for research funding from India and abroad. He has been ranked 114th in the list of the world’s best scientists and 2nd in India by the Stanford University Ranking in Polymers. He was elected as a Fellow of the European Academy of Sciences. Considering his excellent contributions in teaching, research and administration, Prof. Thomas is the best candidate for the outstanding Alumnus award of IIT KGP.
Affiliations and Expertise
Vice Chancellor, Mahatma Gandhi University, and Director of the School of Energy Materials, Mahatma Gandhi University, Kottayam, Kerala, India