Nanoparticles in Translational Science and Medicine

Nanoparticles in Translational Science and Medicine

1st Edition - November 14, 2011

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  • Editor: A Villaverde
  • Hardcover ISBN: 9780124160200
  • eBook ISBN: 9780123914637

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This volume explores some of the most exciting recent advances in basic research on nanoparticles in translational science and medicine and how this knowledge is leading to advances in the various fields.

Key Features

  • This series provides a forum for discussion of new discoveries, approaches, and ideas
  • Contributions from leading scholars and industry experts
  • Reference guide for researchers involved in molecular biology and related fields


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Table of Contents

  • Contributors


    Liposomes and Other Vesicular Systems

    I. Introduction

    II. Description and Classification of Vesicles

    III. Techniques for Vesicle Structural Characterization

    IV. Vesicles as Carriers for the Delivery of Bioactive Molecules

    V. Methods of Preparation

    VI. Conclusions and Future Challenges

    Luminescent Quantum Dots, Making Invisibles Visible in Bioimaging

    I. Introduction

    II. Preparation of QDs for Bioconjugation

    III. Labeling Cell Surfaces with QDs

    IV. Delivery of QDs in Living Cells

    V. Photodynamic Therapy by Quantum Dots

    VI. Concluding Remarks

    Fabrication of Dendrimers Toward Biological Application

    I. Introduction

    II. Are Dendrimers Attractive in Biomedical Sciences?

    III. Drug Delivery Systems of Dendrimers

    IV. Targeting Delivery of Dendrimers

    V. Dendrimers for Therapy

    VI. Dendrimers as Imaging Agents for Inspection

    VII. Conclusions

    Carbohydrate-Based Nanoparticles for Potential Applications in Medicine

    I. Introduction

    II. Metallic Carbohydrate-Based Nanoparticles for In Vitro Detection of Cells and Pathogens

    III. Metallic Carbohydrate-Based Nanoparticles for In Vivo Diagnosis by Magnetic Resonance Imaging

    IV. Metallic Carbohydrate-Based Nanoparticles for In Vivo Diagnosis by Optical Imaging

    V. Metallic Carbohydrate-Based Nanoparticles in Therapy

    VI. NonMetallic Polysaccharide-Based Nanoparticles in Therapy

    VII. Conclusions


    Carbon Nanotubes

    I. Introduction

    II. Characterization

    III. Synthesis

    IV. Post-Synthesis

    V. Biomedical Applications

    VI. Summary and Outlook

    Engineered Biological Entities for Drug Delivery and Gene Therapy

    I. Introduction

    II. Protein Nanoparticle Formulation and Biological Barriers

    III. Multifunctional Proteins

    IV. Natural Self-Assembling Protein Nanoparticles: VLPs

    V. Nonviral Self-Assembling Proteins

    VI. Medical Applications of Protein Nanoparticles

    VII. Conclusions


    Polymer Nanoparticles

    I. Definition and General Ingredients of Polymer Nanoparticles

    II. Production Procedures

    III. Characterization, Quality, and Stability of Polymer Nanoparticles

    IV. Applications of Microbial PHA-Based Nanoparticles

    V. Summary and Outlook


    Nanobiotechnology and Personalized Medicine

    I. Introduction

    II. Role of Nanodiagnostics in Personalized Medicine

    III. Nanobiotechnology, Biomarkers, and Personalized Medicine

    IV. Nanoparticle-Based Combination of Diagnostics and Therapeutics

    V. Discovery, Development, and Delivery of Personalized Nanomedicines

    VI. Personalized Nanooncology

    VII. Personalized Nanoneurology

    VIII. Personalized Nanocardiology

    IX. Future Prospects of Personalized Nanomedicine

    Tissue Engineering Using Magnetite Nanoparticles

    I. Introduction

    II. Magnetofection

    III. Magnetic Patterning of Cell

    IV. Construction of 3D Tissue-Like Structures

    V. Conclusion

    Peptide Nanoparticles for Oligonucleotide Delivery

    I. Introduction

    II. Gene Therapy

    III. Uptake Mechanisms of CPPs

    IV. CPPs for Noncovalent Nanoparticle Formation

    V. CPP-Based Nanoparticles and Their Applications

    VI. Future Directions and Perspective with CPP-Based Nanoparticles


    Nanoparticles in Molecular Diagnostics


    I. Unique Properties of Nanoparticles for Molecular Diagnostics

    II. Molecular Diagnostics by Nucleic Acid Detection

    III. Molecular Diagnostics by Immunoassays

    IV. Conclusions and Future Perspectives


    Nanoparticles in Cancer Chemotherapy

    I. Introduction

    II. Physicochemical Properties of Nanoparticles and Impact on Tumor Targeting

    III. Engineering Nanoparticles for Therapeutic and Imaging Purposes

    IV. Shape–Size Effect of Nanoparticles

    V. Current Status of Nanoparticles in Clinics

    VI. Conclusion

    Nanoparticles in Gene Therapy

    I. Introduction

    II. Barriers and Strategies to Gene Delivery

    III. NPs Used in Gene Therapy

    IV. Challenges and Prospects

    Cell Delivery of Therapeutic Nanoparticles

    I. Translational Pathways for Cell-Based Nanomedicines

    II. Nanomedicines for the Diagnosis and Treatment of Cancer, Infectious and Degenerative Diseases, and Tissue Repair

    III. Chemical Composition, Structure, Function, and Manufacture

    IV. Targeted Drug Delivery

    V. Nanomedicine and Vaccines

    VI. Nanodevices and Cell Reprogramming

    VII. Nanomedicine and Stem Cells

    VIII. Potential of Nanotherapeutics

    IX. Nanotoxicology: Immunogenicity, Cytotoxicity, and Generation of ROS

    X. Unique Challenges for Translational Nanomedicine

    XI. Development of Cell-Based Nanomedicine: A Perspective



Product details

  • No. of pages: 648
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: November 14, 2011
  • Imprint: Academic Press
  • Hardcover ISBN: 9780124160200
  • eBook ISBN: 9780123914637

About the Serial Volume Editor

A Villaverde

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