Handbook of Models for Human Aging

1st Edition - February 24, 2006

Editors: P. Michael Conn, Stephen A. Benjamin, Caleb E. Finch, John C. Guerin, James F. Nelson, S. Jay Olshansky, George Roth, Roy G. Smith

Hardback ISBN:

9 7 8 - 0 - 1 2 - 3 6 9 3 9 1 - 4

eBook ISBN:

9 7 8 - 0 - 0 8 - 0 4 6 0 0 6 - 2

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model,… Read more

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The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.

I. Introduction

1. Historical Development of Animal Models of Aging
Richard L Sprott, Steven N Austad

2. Species Selection in Comparative Studies of Aging and Anti-Aging
Joao Pedro de Magalhaes

3. Principles of Animal Use for Gerontological Research
Richard A. Miller

4. From Primary Cultures to the Aging Organism: Lessons from Human T Lymphocytes
Rita B Effros

5. Models of Systems Failure in Aging
Leonid A Gavrilov, Natalia S. Gavrilova

6. Major Issues in Ethics of Aging Research
Michael D Smith

7. Ethical Aspects of Research Involving Elderly Persons
Paul S Mueller, C. Christopher Hook

II. General Methods

8. SAGE KE and Other Online Resources Related to Aging
Evelyn Strauss, R. John Davenport

9. Proteomics in Aging Research
Christian Schoneich

10. Application of High-throughput Technologies to Aging-related Research
Matt Kaeberlein

11. Models of Alzheimer's Disease
Harry LeVine, III, Lary C Walker

12. Age-Related Hippocampal Dysfunction: Early Alzheimer's Disease vs Normal Aging
Scott A Small

13. Epidemiology in Aging Research
Hermann Brenner, Volker Arndt

14. Statistical Issues for Longevity Studies in Animal Models
Chenxi Wang, Scott Keith, Kevin R Fontaine, David B Allison

15. Models for the Study of Infection in Populations
John R Williams

16. Estimation of the rate of production of oxygen radicals at mitochondria
Alberto Sanz, Gustavo Barja

III. Animal Models

A. Premammalian Systems

17. Telomeres and Aging in the Yeast Model System
Kurt W Runge

18. Longevity and Aging in the Budding Yeast
Matt Kaeberlein

19. From Yeast Methuselah Genes to Evolutionary Medicine
Paolo Fabrizio, Valter D. Longo

20. Strongyloides Ratti: A Nematode with Extraordinary Plasticity in Aging
Michael P. Gardner, David Gems, Mark Viney

21. Insect Models for the Study of Aging
Klaus-Guenter Collatz

22. Drosophila Models of Aging
Satomi Miwa, Alan Cohen

23. Models of Aging in Honeybee Workers
Gro V Amdam, Olav Rueppel

24. Ants as Naturally Long-lived Insect Models for Aging
Joel D Parker, Karen M Parker

B. Mammalian Systems

25. Gene Expression and the Extended Longevity Phenotypes of Drosophila melanogaster
Robert Arking

26. Annual Fish as a Genetic Model for Aging
Pudur Jagadeeswaran

27. The Use of Mature Zebrafish (Danio rerio) as a Model for Human Aging and Disease
Evan T Keller, Jill M. Keller, Gavin Gillespie

28. Zebrafish as Aging Models
Shuji Kishi

29. Telomeres In Aging: Birds
Susan E. Swanberg, Mary E. Delany

30. Domestic and Wild Bird Models for the Study of Aging
Donna J. Holmes, M.A. Ottinger

31. A Transgenic Mini Rat Strain as a Tool for Studying Aging and Calorie Restriction
Isao Shimokawa

32. Rat Models of Age-related Cognitive Decline
Jennifer L Bizon, Michelle M Nicolle

33. Aged Rodents for Biogerontology Research
Nancy L. Nadon

34. Life Extension in the Dwarf Mouse
Andrzej Bartke

35. The Canine Model of Human Brain Aging: Cognition, Behavior, and Neuropathology
P Dwight Tapp, Christina T Siwak

36. Bats as a Novel Model for Aging Research
Anja K Brunet-Rossinni, Rocco E. Rossinni

37. Memory in the Aging Hippocampus: What can place cells tell us?
Iain A Wilson

38. The Rhesus Macaque as a Model of Human Aging and Age-Related Disease
Mary Ann Ottinger, Jullie A. Mattison; Mary B. Zelinski, Julie M. Wu, Steve Kohama, George S. Roth, Mark A. Lane, Donald K. Ingram

39. Non-human Primates as a Model for Reproductinve Aging and Human Infertility
Barry D. Bavister, Carol A. Brenner

IV. Comparative Models

40. Neurobiology of the Aging Brain
Carlo Bertoni-Freddari, Patrizia Fattoretti, William Meier-Ruge

41. Mitochondrial DNA and Aging
Mikhail Alexeyev, Susan P. LeDoux, Glen L. Wilson

42. Models for Apoptosis
Christiane Charriaut-Marlangue, Sylvain Renolleau

43. Age-related Changes in Hormones and Their Receptors in Animal Models of Female Reproductive Senescence
Jacqueline A. Maffucci, Andrea C. Gore

44. Models of Chaperones in Aging
Jens Kroll, J. O. Nehlin

45. Therapeutic Potential of Stem Cells In Aging Related Diseases
Shannon Whirledge, Kirk C.L. Lo, and Dolores J. Lamb

46. Nuclear Transfer and Cloning: Preservaton or Expansion of Proliferative Lifespan?
Keith E Latham

47. Human Models of Longevity
Thomas Perls

48. Computational Models of Mitochondrial DNA in Aging
David C Samuels

49. Mouse Models of Accelerated Aging
Jan Vijg, Paul Hasty

V. Disease-States and Normal Aging

A. Disease States

50. Models, Definitions, and Criteria of Frailty
David B. Hogan

51. Fertility and Aging Men
Peter N Schlegel, Puneet Masson, Sarah M. Lambert, Harry Fisch

52. Benign Prostatic Hyperplasia
Peter N Celec

53. Murine Models of Infectious Diseases in the Aged
Kevin P High

54. Physiopathology, clinical symptoms and causative agents of pneumonia
Jean-Paul Janssens

55. Diabetes and Aging
Tamas Fulop, A. Larbi; D. Tessier, A. Carpentier

56. Diabetes as a Model of Premature Aging
Arshag D Mooradian

57. Frailty as a Model of Aging
Jeremy D. Walston

58. Osteoporosis and Cardiovascular Disease in the Elderly
Samy I McFarlane, MD, FACP, FACE, CCD, John Nicasio, Ranganath Muniyappa

59. Depression in Older Patients
Kiran Rabheru

60. The Aging Human Lung: Age-associated Changes in Structure and Function
Keith C. Meyer

61. Iceland as a Model for Human Aging
Adalsteinn Gudmundsson, Palmi V Jonsson

62. Behavior and Personality in the Study of Successful Aging
Judith Corr, Lorraine Tarou

B. Health Issues Affecting the Elderly

63. Andropause
Rabih Hijazi, Glenn R. Cunningham*

64. Aging and the perceptual organization of sounds: a change of scene?
Claude Alain, Benjamin J. Dyson, Joel S. Snyder

65. Models of Immune Function in Aging
Christopher A. Jolly, Zhun Xu

66. Human T Cell Clones in Long-term Culture as Models for the Impact of Chronic Antigenic Stress in Aging
Graham Pawelec, Erminia Mariani, Rafael Solana, Rosalyn Forsey, Anis Larbi, Simone Neri, Olga Dela Rosa, Yvonne Barnett, Jon Tolson, Tamas Fulop

67. Age-Related Changes in the Human Retina
Carlo Cavallotti, Nicola Pescosolido

68. Models of Age Related Vision Problems
J. Fielding Hejtmancik, Mark Kantorow, Takeshi Iwata

69. Health, Functional and Therapeutic Implications of Obesity in Aging
R L Kennedy, E Y H Khoo

70. Age and Joints
Klaus Bobacz, Ilse-Gerlinde Sunk

71. Sleep Quality in the Elderly
Ragnar Asplund

72. Atherogenesis and Aging
Cam Patterson

73. Managing Menopausal Symptons
Mary Ellen Rousseau

74. Psychological Aging: A Contextual View
Hans-Werner Wahl, Frieder R. Lang

75. Nutrients and Aging
Lawrence J Whalley

C. Approaches to Treatment and Models

76. Methods for Studying Hearing Impairment and Auditory Problems of the Aged
Robert D Frisina, D. Robert Frisina

77. A Model for Understanding the Pathomechanics of Osteoarthritis in Aging
Thomas P Andriacchi, Annegret Mundermann

78. Aging and Cardiovascular Angiogenesis Models
Andrew Chin, Jacquelyn M. Holm, Inga J. Duignan, and Jay M. Edelberg*

79. Models for the Study of Stroke
Thiruma V. Arumugam, Mark P. Mattson*

80. Werner Syndrome as a Model of Human Aging
Raymond J Monnat, Jr

81. Models of Sarcopenia
Alfred L Fisher

82. Aging of Human Skin
Paolo U Giacomoni

83. Models of Hypertension in Aging
Jane F Reckelhoff, Radu Iliescu, Licy Yanes, Lourdes A Fortepiani

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.

Affiliations and expertise

Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center, TX, USA

Caleb E. Finch

Dr. Finch’s major research interest is the study of basic mechanisms in human aging with a focus on inflammation. He has received numerous awards in biomedical gerontology, including the Robert W. Kleemeier Award of the Gerontological Society of America in 1985, the Sandoz Premier Prize by the International Geriatric Association in 1995, and the Irving Wright Award of AFAR and the Research Award of AGE in 1999. He was the founder of the NIA-funded Alzheimer Disease Research Center in 1984 and currently serves as co- Director.

Dr. Finch became a University Distinguished Professor in 1989, an honor held by sixteen other professors at USC who contribute to multiple fields. He is a member of five editorial boards and has written four books including The Biology of Human Longevity (Academic Press 2007) as well as over 470 articles.

Affiliations and expertise

ARCO/William F. Kieschnick Chair in the Neurobiology of Aging and Professor of Gerontology, Biological Sciences, Anthropology, and Psychology, University of Southern California, Los Angeles, CA, USA