Pulsatility in Neuroendocrine Systems

1st Edition - May 19, 1994

Editors: Jon E. Levine, P. Michael Conn

eBook ISBN:

9 7 8 - 1 - 4 8 3 2 - 8 8 3 4 - 5

Pulsatility is now recognized as a nearly ubiquitous functional feature of neuroendocrine systems. This volume presents a comprehensive guide to the established and emerging… Read more

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Pulsatility is now recognized as a nearly ubiquitous functional feature of neuroendocrine systems. This volume presents a comprehensive guide to the established and emerging technologies being used to study the perplexing phenomenon of pulsatility. Molecular, cellular, physiological, and mathematical approaches are described in detail.

Molecular and Cellular Assessment of Pulsatility:
G.M. de la Escalera and R.I. Weiner, Analysis of Pulsatility in Immortalized GnRH Cell Lines.
S. Wray, Use of Organotypic Cultures for the Study of Neuroendocrine Cells.
Electrophysiological and Ionic Events in Pulsatility:
M.J. Kelly and O.K. RØnnekleiv, Electrophysiological Analysis of Neuroendocrine Neuronal Activity in Hypothalamic Slices.
S.S. Stojilkovic, L.Z. Krsmanovic, D.J. Spergel, M. Tomic,and K.J. Catt, Calcium Signaling and Episodic Secretory Responses of GnRH Neurons.
A. Tse and B. Hille, Patch-Clamp Studies on Identified Pituitary Gonadotropes in Vitro.
K.T. O'Byrne and E. Knobil, Electrophysiological Analysis of GnRH Pulse Generator Activity in the Rhesus Monkey.
M. Nishihara, Y. Mori, M.-J. Yoo, and M. Takahashi, In Vivo Electrophysiological Monitoring of the GnRH Pulse Generator in Rats and Goats.
Central and Peripheral Sampling of Pulses in Vivo:
J.E. Levine, A.M. Wolfe, T. Porkka-Heiskannen, J.M. Meredith, J.R. Norgle, and F.W. Turek, In Vivo Sampling and Administration of Hormone Pulses in Rodents.
A. Caraty, A. Locatelli, S.M. Moenter, and F.J. Karsch, Sampling of Hypophyseal Portal Blood of Conscious Sheep for Direct Monitoring of Hypothalamic Neurosecretory Substances.
E. Terasawa, in Vivo Measurement of Pulsatile Release of Neuropeptides and Neurotransmitters in Rhesus Monkeys Using Push-Pull Perfusion.
C.J. Goodner, In VitroSystems for Modeling Target Tissue Responses to Secretory Pulses of the Islet Hormones: Glucagon and Insulin.
S.M. Yellon and E.M. Apostolakis, Pulsatile Endocrine Secretion in the Ovine Fetus.
M.S. Jasper, J.T. Walworth, and W.C. Engeland, Pulsatile Corticosterone Secretion as Measured by Intraadrenal Microdialysis.
Mathematical Procedures for Pulse Analysis:
R.J. Urban, Comparative Analysis and Procedures for Validation of Pulse-Detection Algorithms.
J.D. Veldhuis, J. Moorman, and M.L. Johnson, Deconvolution Analysis of Neuroendocrine Data: Waveform-Specific and Waveform-Independent Methods and Applications.
G.R. Merriam and K.W. Wachter, Analysis of the Temporal Coincidence of Hormonal Pulses.
J.D. Veldhuis, M.L. Johnson, L.M. Faunt, and E. Seneta, Assessing Temporal Coupling between Two or among Three or More Neuroendocrine Pulse Trains.
K. Prank and G. Brabant, Estimating Thyrotropin Secretory Activity by a Deconvolution Procedure.
Modeling Techniques for Pulsatile Systems:
J. Sturis, E. Mosekilde, and E. Van Cauter, Modeling Modulatory Effects on Pulsatility.
R.P. Murray-McIntosh and J.E.A. McIntosh, Modeling Pulsatile Hormone Stimulation of Cell Responses.
Endocrine Consequences of Pulsatile Hormone Stimulation:
M.A. Shupnik, Pulsatile Neuropeptide Delivery and Analysis of Hormone Biosynthesis.
J.F. Ackland, K.L. Knox, A.A. Elskus, P.C. Fallest, E.S. Hiatt, and N.B. Schwartz, Use of an in Vitro Perifusion System to Study the Effects of Pulsatile Hormone Administration on the Control of the Hypothalamic-Pituitary-Ovarian Axis.
P.J. Lefebvre, G. Paolisso, and A.J. Scheen, Pulsatile Administration of Insulin and Glucagon in Man.
Index.

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.

Affiliations and expertise

Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center, TX, USA