Future Directions in Biocatalysis, Second Edition, presents the future direction and latest research on how to utilize enzymes, i.e., natural catalysts, to make medicines and other necessities for humans. It emphasizes the most important and unique research on biocatalysis instead of simply detailing the ABC’s on the topic.
This book will help new researchers in the field identify specific needs, start new projects that address current environmental concerns, and develop techniques based on green technology. In addition, users will find invaluable hints and clues regarding new research topics using enzymes, with final sections outlining future directions in biocatalysis that further expand the science into new applications.
- Gives future directions in the area of biocatalysis research
- Presents research topics based on their uniqueness, originality, and novelty
- Includes many explanatory figures to demonstrate concepts to both organic chemists and biochemists
- Shows that there is no boundary between organic chemistry and biochemistry
University and industry researchers with their specialties in synthetic organic chemistry, biocatalysis, or enzymology: chemists and chemical engineers, biochemists, researchers in chemical and pharmaceutical industries, plus as a reference book for graduate courses in bioorganic engineering and bioengineering
The new materials to this editions are:
1. X-ray crystal structure determination
2. Simulation for prediction of enzyme functions
Although both of them had existed in 2007, the applications of them to biocatalysis had been limited at that time. Now, they have been widely available and necessary for the development of biocatalysis.
Basically, modifications to the 1st edition will be done.
Now, two contributors agreed to write a chapter.
Prof T. Itoh (Tottori Univ.) agreed to re-write the chapter entitled "Biotransformation in ionic liquid"(Chapter 1 in 1st edition). He also thinks the new editions is necessary, now.
Prof. Yamanaka (Himeji-Dokkyo University) agreed to re-write the chapter entitled "Utilization of light energy for reactions using biocatalysis" (chapter 3 in 1st edition).
I will also write a chapter about utilization of liquid and supercritical CO2 as solvents for biocatalysis.
The below is the table of contents of the 1st edition.
Part One: Novel reaction conditions for biotransformation
Chapter 1 - Biotransformation in ionic liquid
Chapter 2 - Temperature control of the enantioselectivity in the lipase-catalyzed resolutions
Chapter 3 - Future directions in photosynthetic organisms-catalyzed reactions
Chapter 4 - Catalysis by enzyme-metal combinations
Part Two: Uncomon kind of biocatalytic reaction
Chapter 5 - Biological Kolbe-Schmitt carboxylation: Possible use of enzymes for the direct carboxylation of organic
Chapter 6 - Discovery, redesign and applications of Baeyer-Villiger monooxygenases
Chapter 7 - Enzymes in Aldoxime-Nitrile pathway: Versatile tools in biocatalysis
Chapter 8 - Addition of hydrocyanic acid to carbonyl compounds
Part Three: Novel compounds synthesized by biotransformations
Chapter 9 - Chiral heteroatom-containing compounds
Chapter 10 - Enzymatic polymerization
Chapter 11 - Synthesis of naturally occurring β-D-glucopyranosides based on enzymatic β-glucosidation using β-glucosidase from almond
Part Four: Use of molecular biology technique to find novel biocatalyst
Chapter 12 - Future directions in alcohol dehydrogenase-catalyzed reactions
Chapter 13 - Enzymatic decarboxylation of synthetic compounds
- No. of pages:
- © Elsevier 2017
- 5th June 2017
- Hardcover ISBN:
Tomoko Matsuda (Associate Professor, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, J3-5 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa, JAPAN 226-8501)
Assoc. Prof. T Matsuda research has been focused on the organic synthesis with enzymes, biocatalysis, for 20 years. Particularly, the study of enzymatic reactions in a non-aqueous solvent. Supercritical and liquid carbon dioxide have been used as a solvent and reactant of the enzymatic reaction to develop environmentally friendly organic synthetic methods. Her group has achieved the waste-minimization in large-scale production of chiral compounds with a flow system using liquid carbon dioxide as a solvent and an immobilized lipase as a catalyst. She has published more than 65 articles in international journals and has an H-index of 25.
Tokyo Institute of Technology, Department of Bioengineering, Yokohama, Japan