Biomaterials for Organ and Tissue Regeneration

Biomaterials for Organ and Tissue Regeneration

New Technologies and Future Prospects

1st Edition - March 19, 2020

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  • Editors: Nihal Vrana, Helena Knopf-Marques, Julien Barthes
  • Paperback ISBN: 9780081029060
  • eBook ISBN: 9780081029077

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Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects examines the use of biomaterials in applications related to artificial tissues and organs. With a strong focus on fundamental and traditional tissue engineering strategies, the book also examines how emerging and enabling technologies are being developed and applied. Sections provide essential information on biomaterial, cell properties and cell types used in organ generation. A section on state-of-the-art in organ regeneration for clinical purposes is followed by a discussion on enabling technologies, such as bioprinting, on chip organ systems and in silico simulations.

Key Features

  • Provides a systematic overview of the field, from fundamentals, to current challenges and opportunities
  • Encompasses the classic paradigm of tissue engineering for creation of new functional tissue
  • Discusses enabling technologies such as bioprinting, organ-on-chip systems and in silico simulations


Biomaterials/Biomedical Engineering/Tissue Engineering researchers; medical researchers in transplant surgery, cardiology, vascular surgery, and related areas; graduate students in biomedical engineering and medicine for courses such as biomaterials, tissue engineering, and regenerative medicine

Table of Contents

  • 1. Introduction

    Section 1: Biomaterials
    2. Classes of Biomaterials used in Tissue/Organ Regeneration
    3. Physicochemical Properties of Biomaterials
    4. Synthesis or Modification of Biomaterials for Regenerative Medicine Applications
    5. Surface Modifications of Biomaterials for Tissue Engineering

    Section 2: Cell microenvironment and signalling
    6. Cell microenvironment and ECM
    7. Cell signalling and strategies to modulate cell behaviour

    Section 3: Cells
    8. Stem cells: sources, properties and cell types
    9. Tissue specific cells: sources, properties and cell types
    10. Cell differentiation: sources, properties and cell types
    11. Immune cells: sources, properties and cell types
    12. Angiogenesis/vascular cells: sources, properties and cell types

    Section 4: Organ specific Artificial tissues/Organs
    13. Heart/Cardiovascular tissues
    14. Respiratory system tissues
    15. Digestive system tissues
    16. Kidney Tissue Engineering
    17. Liver Tissue Engineering
    18. Pancreas Tissue Engineering
    19. Neural Tissue Engineering
    20. Musculoskeletal Tissue engineering

    Section 5: Biotechnological approaches and Enabling technologies related to organ regeneration
    21. Emerging biotechnological approaches with respect to organ regeneration: SiRNA, miRNA, CRISPR, CAR-T therapy, -omics approaches etc.
    22. Bioreactors
    23. On-chip organ systems
    24. In vitro disease and organ models
    25. Bioprinting
    26. Biorobotics
    27. Imaging techniques for biomaterials, stem cells and engineered tissues/organs
    28. Future perspectives/Industrialisation and Up-scaling of organ regeneration technologies

Product details

  • No. of pages: 846
  • Language: English
  • Copyright: © Woodhead Publishing 2020
  • Published: March 19, 2020
  • Imprint: Woodhead Publishing
  • Paperback ISBN: 9780081029060
  • eBook ISBN: 9780081029077

About the Editors

Nihal Vrana

Nihal Vrana is Co-founder of SPARTHA Medical. He holds B.Sc. (Biology) and M.Sc. (Biotechnology) degrees from Middle East Technical University. He obtained his PhD at Dublin City University as a Marie Curie ESR fellow. His major research interests are titanium and silicone implants, tissue engineering, cell encapsulation, antimicrobial surfaces, multifunctional coatings, immunomodulation, real-time monitoring of implants, biomaterial risk assessment and cell biomaterials interactions. He has coordinated 2 multi-partner, multinational EU projects (BiMot and IMMODGEL ( and is currently coordinating a H2020 project (PANBioRA,

Affiliations and Expertise

Co-founder and CEO of SPARTHA Medical, Strasbourg, France, and Affiliated Researcher at the University of Strasbourg, France

Helena Knopf-Marques

Helena Knopf-Marques is a Senior Researcher at PROTiP Medical. She has also been associate professor at Strasbourg University. She has been working with the development of new biomaterials since her graduation. She is a Chemical Engineer with a masters in Mechanical Engineering. She received her PhD from the Program in Metallurgical and Materials Engineering at Federal University of Rio de Janeiro. Her main research interests are tissue engineering, multifunctional coatings, immunomodulation of biomaterial surfaces, 3D printing and cell biomaterial interactions. She is presently working on the EU Horizon 2020 project PANBioRA that aims to develop new instruments for biomaterials characterization and risk assessment.

Affiliations and Expertise

Senior Researcher, PROTiP Medical

Julien Barthes

Dr. Julien Barthes is collaborative Project Manager at PROTiP MEDICAL. He holds two master’s degrees in physical/chemical properties of polymers and in polymer science (ECPM, Strasbourg). He obtained in PhD in 2014 at Strasbourg in Inserm (French National Institute of Health and Medical Research) in “Biomaterials and Bioengineering” department His main research areas are hydrogel development, titanium implants, tissue engineering, cell biomaterials interactions, release of bioactive molecules in cell microenvironment and 3D printing. He is a scientific contributor in Horizon 2020European Project (PANBioRA) about biomaterial risk assessment. He is also in charge of the development of patient specific 3D printed medical implant from bench to market.

Affiliations and Expertise

Project Manager, PROTiP Medical

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