5-Membered Heterocycle Synthesis Using Iodine

5-Membered Heterocycle Synthesis Using Iodine

1st Edition - October 1, 2022

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  • Author: Navjeet Kaur
  • Paperback ISBN: 9780443189418

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Description

Heterocyclic frameworks represent the main structural subunits of many biologically active compounds and natural products. The ability of heterocycles to act both as reactive pharmacophores and biomimetics has greatly contributed to their unique value as traditional key elements of various drugs. The contemporary developments in process chemistry and discovery emphasize novel sustainable synthetic pathways as fast and ecologically acceptable alternatives to the traditional protocols. The development of sustainable synthetic process to substitute the efficient but somewhat old classical methodologies started many years back and such methodologies are still in high demand.  The increasing demand for fast formation of biologically active molecules has stimulated synthetic researchers to discover and develop smart approaches that inevitably address the very fundamental principles of effectiveness and efficiency. Besides the critical issues of stereo-, chemo-, and regioselectivity, nowadays, these processes also have to account economical and environment concerns of green chemistry. The intellectual difficulty to discover well-designed, concise, and conceptually new synthetic pathways has become a gradually increasing driving force in industry and academia. Since the last few years, chemists are very concerned about the environmental implications of their work. They are trying to develop novel reaction conditions, synthetic strategies, and use of chemicals that minimize risks to environment and humans. The development of harmless, atom efficient, and acid-mediated organic procedures is the most important challenge in green chemistry. While acid catalysis remains the most broadly utilized kind of catalysis, the generally employed acid catalysts continue to pose severe safety and health issues. The mild Lewis acidity of I2 has increased its applicability for many organic reactions.

Key Features

  • Covers the applications of five-membered heterocycles
  • Highlights methodologies for the synthesis of five-membered heterocycles using iodine
  • Contains the most up-to-date information in this fast-moving field

Readership

Students and Researchers in Chemistry, Synthetic Chemists, Organic Chemists

Table of Contents

  • 1. Five-membered N-heterocycles
    2. Five-membered N-heterocycles: Cyclization of alkenyl or alkynyl systems
    3. Five-membered N,N-, N,N,N-, and N,N,N,N-heterocycles
    4. Five-membered O-heterocycles: Cyclization of C=C with OH
    5. Five-membered O-heterocycles: Cyclization of alkenyl or alkynyl compounds
    6. Five-membered O- and O,O-heterocycles
    7. Five-membered O,N-heterocycles
    8. Five-membered O,N,N-heterocycles: Hydrazine derivatives
    9. Five-membered S-heterocycles
    10. Five-membered S,N-heterocycles

Product details

  • No. of pages: 600
  • Language: English
  • Copyright: © Elsevier 2023
  • Published: October 1, 2022
  • Imprint: Elsevier
  • Paperback ISBN: 9780443189418

About the Author

Navjeet Kaur

Dr. Navjeet Kaur received her BSc from Panjab University Chandigarh (Panjab, India) in 2008. In 2010, she completed her MSc in Chemistry from Banasthali Vidyapith. She was awarded with PhD in 2014 by the same university.  With 11 years of teaching experience, she has published over 160 scientific research papers, review articles, book chapters, and monographs in the field of organic synthesis in national and international reputed journals. She has published five authored books: with Elsevier. She secured her place amongst top 2% scientists of the world in 2017 (single year ranking), 2018 (full career wise ranking), 2019 [full career wise ranking with 424 world rank (04 in India) and single year ranking with 03 world rank (01 in India)] and 2020 (full career wise ranking with 372 world rank and single year ranking with 126 world rank). In 2021, Dr. Kaur was chosen as a candidate for membership by Royal Society of Research, London, England, UK with full waiver of application fees. She is serving as an Editor-in-Chief for “Advanced Chemicobiology Research” journal.

Affiliations and Expertise

Department of Chemistry, Banasthali Vidyapith University, India

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