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3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine
1st Edition - January 6, 2015
Editors: Lijie Grace Zhang, Kam Leong, John P. Fisher
Language: English
Hardback ISBN:9780128005477
9 7 8 - 0 - 1 2 - 8 0 0 5 4 7 - 7
eBook ISBN:9780128006641
9 7 8 - 0 - 1 2 - 8 0 0 6 6 4 - 1
3D Bioprinting and Nanotechnology in Tissue Engineering provides an in depth introduction to these two technologies and their industrial applications. Stem cells in tissue re…Read more
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3D Bioprinting and Nanotechnology in Tissue Engineering provides an in depth introduction to these two technologies and their industrial applications. Stem cells in tissue regeneration are covered, along with nanobiomaterials. Commercialization, legal and regulatory considerations are also discussed in order to help you translate nanotechnology and 3D printing-based products to the marketplace and the clinic. Dr. Zhang’s and Dr. Fishers’ team of expert contributors have pooled their expertise in order to provide a summary of the suitability, sustainability and limitations of each technique for each specific application.
The increasing availability and decreasing costs of nanotechnologies and 3D printing technologies are driving their use to meet medical needs, and this book provides an overview of these technologies and their integration. It shows how nanotechnology can increase the clinical efficiency of prosthesis or artificial tissues made by bioprinting or biofabrication. Students and professionals will receive a balanced assessment of relevant technology with theoretical foundation, while still learning about the newest printing techniques.
Includes clinical applications, regulatory hurdles, and risk-benefit analysis of each technology.
This book will assist you in selecting the best materials and identifying the right parameters for printing, plus incorporate cells and biologically active agents into a printed structure
Learn the advantages of integrating 3D printing and nanotechnology in order to improve the safety of your nano-scale materials for biomedical applications
Engineers, academics, students, clinicians and professionals in biomedical engineering, medical devices, tissue engineering, and biomaterials
List of Contributors
Preface
Chapter 1: Nanotechnology: A Toolkit for Cell Behavior
Abstract
1.1. Introduction
1.2. Nanobiomaterials for Tissue Regeneration
1.3. 3D Nano/Microfabrication Technology for Tissue Regeneration
1.4. Conclusion and Future Directions
Acknowledgments
Chapter 2: 3D Printing and Nanomanufacturing
Abstract
2.1. Introduction
2.2. 3D Printing and Nanomanufacturing Techniques
2.3. Biomaterials Used with Additive Biomanufacturing Techniques
2.4. Cells and Bioapplications
2.5. Discussion: Pros and Cons of Each Technique
2.6. Summary
Chapter 3: 3D Bioprinting Techniques
Abstract
3.1. Introduction
3.2. Definition and Principles of 3D Bioprinting
3.3. 3D Bioprinting Technologies
3.4. Challenges and Future Development of 3D Bioprinting
3.5. Conclusion
Chapter 4: The Power of CAD/CAM Laser Bioprinting at the Single-Cell Level: Evolution of Printing
Abstract
4.1. Introduction
4.2. Basics of Laser-Assisted Printing: Overview of Systems and Critical Ancillary Materials
4.3. MAPLE-DW Mechanics
4.4. Cell Viability
4.5. Case Studies and Applications Illustrating the Importance of Single-Cell Deposition
4.6. Conclusion
Chapter 5: Engineering 2D and 3D Cellular Microenvironments Using Laser Direct Write
Abstract
5.1. Introduction
5.2. Materials in LDW
5.3. LDW Applications in 2D
5.4. LDW Applications in 3D
5.5. Conclusions and Future Directions
Acknowledgments
Chapter 6: Biomaterials for Bioprinting
Abstract
6.1. Introduction
6.2. Parameters for Bioprinting
6.3. Hydrogel Cross-Linking Mechanism
6.4. Hydrogels in Bioprinting
6.5. Integrative Support Materials
6.6. Conclusion
Chapter 7: Blood Vessel Regeneration
Abstract
7.1. Introduction
7.2. Future Directions
Acknowledgments
Chapter 8: 3D Printing and Patterning Vasculature in Engineered Tissues
Abstract
8.1. Introduction
Chapter 9: Craniofacial and Dental Tissue
Abstract
9.1. Introduction
9.2. Clinical Need for Craniofacial and Dental Regenerative Medicine
9.3. Craniofacial and Dental Regenerative Medicine Research
9.4. Bone Tissue Engineering Strategies
9.5. Conclusions
Acknowledgment
Chapter 10: Craniofacial Bone
Abstract
10.1. Introduction
10.2. Craniofacial Bone Structure
10.3. Different 3D Printing Techniques and Their Application to Craniofacial Scaffolds
10.4. Nanotechnology in Craniofacial Graft Design
10.5. Summary
Chapter 11: Additive Manufacturing for Bone Load Bearing Applications
Abstract
11.1. Need for Bone Substitutes
11.2. Compositional, Structural and Mechanical Properties of Bone
11.3. Difficulties in Achieving an Ideal Bone Substitute
11.4. Metallic Bone Substitutes
11.5. Bioceramic Bone Substitutes
11.6. Nanocomposite Bone Substitutes
11.7. Conclusions
Chapter 12: Cartilage 3D Printing
Abstract
12.1. General Introduction
12.2. Future Directions
Acknowledgments
Chapter 13: Bioprinting for Skin
Abstract
13.1. Skin, Skin Substitutes, Possible Applications for Printed Skin
13.2. Epidermis
13.3. Research
13.4. Conclusion
Acknowledgments
Chapter 14: Nanotechnology and 3D Bioprinting for Neural Tissue Regeneration
Abstract
14.1. Introduction
14.2. Nanotechnology for Neural Tissue Regeneration
14.3. 3D Bioprinting for Neural Tissue Regeneration
14.4. Conclusion and Future Directions
Acknowledgments
Chapter 15: Organ Printing
Abstract
15.1. Introduction
Chapter 16: Intellectual Property in 3D Printing and Nanotechnology
Abstract
16.1. Introduction
16.2. Why is Intellectual Property Important?
16.3. Types of Intellectual Property
16.4. Where does Intellectual Property Law Originate?
16.5. What Aspects of 3D Bioprinting and Nanotechnology are Protectable?
16.6. Intellectual Property Protection Limitations for Engineered Tissue
16.7. Ethical Considerations of Engineered Tissue Intellectual Property
16.8. Intellectual Property Infringement
16.9. Conclusion
Index
No. of pages: 392
Language: English
Edition: 1
Published: January 6, 2015
Imprint: Academic Press
Hardback ISBN: 9780128005477
eBook ISBN: 9780128006641
LZ
Lijie Grace Zhang
Dr. Zhang is the Director of the Bioengineering Laboratory for Nanomedicine and Tissue Engineering. Her research interests include 3D/4D bioprinting, nanotechnology, complex tissue engineering, cancer metastasis model, and soft bio-robotics. She is a Fellow of the American Institute for Medical and Biological Engineering and has received many prestigious awards including NIH Director’s New Innovator Award. Dr. Zhang is currently the Editor-in-Chief of Biomedical Engineering Advances and Associate Editors for several high-impact international journals.
Affiliations and expertise
Professor and Associate Dean for Research, School of Engineering and Applied Science, The George Washington University, USA
KL
Kam Leong
Dr. Leong is the Director of Nanotherapeutics and Stem Cell Engineering Laboratory. His research focuses on the development of innovative biomaterials for drug and delivery, nonviral gene editing, and regenerative medicine. He is a member of the National Academy of Engineering, National Academy of Medicine, and National Academy of Inventors, and the Editor-in-Chief of Biomaterials.
Affiliations and expertise
Samuel Y. Sheng Professor, Department of Biomedical Engineering, Columbia University
JF
John P. Fisher
Dr. Fisher is the Director of the Tissue Engineering and Biomaterials Laboratory and investigates biomaterials, stem cells, and bioreactors for the regeneration of lost tissues, particularly bone, cartilage, vasculature, and skeletal muscle. In 2012 Dr. Fisher was elected Fellow of the American Institute for Medical and Biological Engineering. Dr. Fisher is currently the co-Editor-in-Chief of the journal Tissue Engineering.
Affiliations and expertise
Fischell Family Distinguished Professor and Chair, Fischell Department of Bioengineering, University of Maryland
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